Aminodiols, aminotetraols and 1,2,3-triazoles based on allo-gibberic acid: stereoselective syntheses and antiproliferative activities

Khdar, Zein Alabdeen [Khdar, Zein Alabdeen (Pharmaceutical Ch...), author] Department of Pharmaceutical Chemistry (SZTE / FP); Le, Tam Minh [Le Minh, Tam (gyógyszerkémia), author] Department of Pharmaceutical Chemistry (SZTE / FP); HUN-REN-SZTE Stereochemistry Research Group (SZTE / FP / DPhC); Schelz, Zsuzsanna [Schelz, Zsuzsanna (Gyógyszerésztudomány), author] Department of Pharmacodynamics and Biopharmacy (SZTE / FP); Zupkó, István [Zupkó, István (Farmakológia), author] Department of Pharmacodynamics and Biopharmacy (SZTE / FP); Szakonyi, Zsolt ✉ [Szakonyi, Zsolt (szerves- és gyógy...), author] Department of Pharmaceutical Chemistry (SZTE / FP)

English Article (Journal Article) Scientific

Published: RSC ADVANCES 2046-2069 2046-2069 14 (49) pp. 36698-36712 2024

SJR Scopus - Chemical Engineering (miscellaneous): Q1

Identifiers

MTMT: 35577548
DOI: 10.1039/D4RA07334G
WoS: 001356415800001
Scopus: 85209255235
PubMed: 39559570
Other URL: https://xlink.rsc.org/?DOI=D4RA07334G
SZTE Publicatio: 35161

Fundings:

(K 138871) Funder: NKFI
(TKP2021-EGA-32) Funder: NRDIO
Open Access Fund(7314) Funder: USZ

Subjects:

Pharmacology and pharmacy
Organic chemistry
Synthetic Organic chemistry

Various allo -gibberic acid modifications yielded aminodiols, aminotetraols, and triazoles. N -naphthyl aminotetraols and di- or tetrahydroxy triazoles with a diaminopyrimidine moiety showed optimal antiproliferative activity.

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Aminodiols, aminotetraols and 1,2,3-triazoles based on allo-gibberic acid: stereoselective syntheses and antiproliferative activities

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