https://m2.mtmt.hu/ hun 2026-05-31 12:06 JournalArticle 35577334 VALIDATED true 0 false 2026-05-24T11:33:29.591+0000 2025-02-20T12:50:38.158+0000 2024-11-18T10:52:43.028+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2025-03-16T13:51:01.614+0000 2024-12-30T08:21:23.010+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Keller, Felix Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease true true /api/journal/13867 REVIEWED true false 13867 false 13867 true 1420-4096 1423-0143 Journal FOREIGN 49 1 1013 1025 1013 13 2024 IntroductionDiabetic kidney disease (DKD) is a common cause of chronic kidney disease with around 25-40% of patients with diabetes being affected. The course of DKD is variable and estimated glomerular filtration rate (eGFR) and albuminuria, the currently used clinical markers, are not able to accurately predict the individual disease trajectory, in particular in early stages of the disease. The aim of this study was to assess the association of urine levels of selected protein biomarkers with the progression of DKD at an early stage of disease.MethodsWe measured 22 protein biomarkers using the Mesoscale Discovery platform in 461 urine samples of the PROVALID cohort, an observational study of patients with type 2 diabetes mellitus followed at the primary health care level for a minimum of four years. Odds ratios (OR) were estimated for the effect of marker values above median on fast progression using unadjusted and adjusted logistic regression models. RNA expression at the single cell level in kidney biopsy samples obtained from a cohort of young persons with type 2 diabetes mellitus was in addition determined for markers showing significant associations with disease progression.ResultsIncreased urinary levels of epidermal growth factor (EGF) were linked to lower odds of fast progression (defined as annual eGFR decline greater than 2.58 ml/min per 1.73 m2) with an odds ratio (OR) of 0.60 (95% CI 0.46, 0.78). The association with outcome was even stronger when adjusting for a set of 14 baseline clinical parameters including age, biological sex, eGFR, body mass index, albuminuria, and HbA1c. Elevated urinary levels of fatty acid binding protein 3 (FABP3) and vascular cell adhesion molecule 1 (VCAM1) were each significantly associated with fast progression with an OR of 1.44 (95% CI 1.11, 1.87) and an OR of 1.41 (95% CI 1.08, 1.83), respectively. Enriched expression of EGF and FABP3 was observed in distal convoluted tubular cells and VCAM1 in parietal epithelial cells at single cell level from biopsies of patients with early DKD.ConclusionIn summary we show that lower urinary levels of EGF and higher urinary levels of FABP3 and VCAM1 are significantly associated with DKD progression in early-stage disease. true true 2024 true true true false true false GOLD 2026-05-24 false http://www.karger.com/kbr 4 0 4 4 0 4 4 4 1 4 4 4 4 4 0 0 4 4 4 4 0 6 6 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb 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0 true false true PersonAuthorship 121646220 /api/authorship/121646220 16 0.04 false false false Bjornstad Petter M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646221 /api/authorship/121646221 17 0.04 false false false Eder Susanne true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646222 /api/authorship/121646222 18 0.04 false false false Author 1152552 /api/author/1152552 Rosivall László true 1152552 true Rosivall Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646223 /api/authorship/121646223 19 0.04 false false false Mark Patrick Barry true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646224 /api/authorship/121646224 20 0.04 false false false Wiecek Andrzej true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646225 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Lamber true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646226 /api/authorship/121646226 22 0.04 false false false Kretzler Matthias true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646227 /api/authorship/121646227 23 0.04 false false false Oberbauer Rainer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646228 /api/authorship/121646228 24 0.04 false false true Mayer Gert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121646229 /api/authorship/121646229 25 0.04 false true true Perco Paul true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 27938270 /api/publicationidentifier/27938270 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1159/000542267 https://doi.org/10.1159/000542267 false true PublicationIdentifier 28438215 /api/publicationidentifier/28438215 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001381799800003 https://www.webofscience.com/wos/woscc/full-record/001381799800003 true true PublicationIdentifier 28133309 /api/publicationidentifier/28133309 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85212003130 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85212003130 false true PublicationIdentifier 28133310 /api/publicationidentifier/28133310 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39510044 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39510044&dopt=Abstract false true Classification 12304 /api/classification/12304 true true SjrRating 11446513 /api/sjrrating/11446513 143 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q2 DIRECT true true /api/publication/35577334 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Keller Felix </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Denicolò Sara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leierer Johannes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kruus Maren </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heinzel Andreas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kammer Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ju Wenjun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nair Viji </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Burdet Frederic </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ibberson Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Menon Rajasree </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Otto Edgar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Choi Ye Ji </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pyle Laura </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ladd Patricia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bjornstad Petter M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eder Susanne </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1152552"><a href="/gui2/?type=authors&mode=browse&sel=1152552" target="_blank">Rosivall Laszlo (<span class="authorship-author-name">Rosivall László</span> <span class="authorAux-mtmt"> Élettan és kórélettan, nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mark Patrick Barry </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wiecek Andrzej </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heerspink Hiddo J. Lamber </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kretzler Matthias </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oberbauer Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mayer Gert ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Perco Paul ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35577334" target="_blank">Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease</a></div> <div> <span class="journal-title">KIDNEY AND BLOOD PRESSURE RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-4096">1420-4096</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1423-0143">1423-0143</a>)</span>: <span class="journal-volume">49</span> <span class="journal-issue">1</span> <span class="page"> pp 1013-1025 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1159/000542267" target="_blank" href="https://doi.org/10.1159/000542267"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001381799800003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001381799800003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85212003130" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85212003130"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39510044" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39510044&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nephrology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35577334&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35577334</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.20. 13:50 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>