https://m2.mtmt.hu/ eng 2026-10-24 06:05 JournalArticle 35576719 VALIDATED true 0 false 2026-07-13T10:14:56.060+0000 2024-12-11T09:51:37.280+0000 2024-11-18T09:01:51.884+0000 true 10066331 Vida Zsuzsa Ágnes /api/admin/10066331 Admin true 2025-04-09T08:55:43.594+0000 2025-03-20T12:44:49.767+0000 2024-11-18T17:59:14.168+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin true 2024-11-19T11:43:49.141+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-06-02T18:20:13.079+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kocsis, Beatrix Could the transcription factor AtnN coordinating the aspercryptin secondary metabolite gene cluster in Aspergillus nidulans be a global regulator? true true /api/journal/10015936 REVIEWED true false 10015936 false 10015936 true 1878-6146 1878-6162 Journal FOREIGN 128 8 2311 2316 2311 6 2024 Products of dormant secondary metabolite gene clusters of fungal genomes can be exploited for medical purposes as bioactive agents. These clusters can be switched on under oxidative stress and may endow fungi with a versatile chemical armory in a competitive niche. In Aspergillus nidulans, the aspercryptin gene cluster, including the synthase [atnA (AN7884)] and its transcription factor (atnN), was activated under menadione sodium bisulfite (MSB) treatment. In this study, we generated and phenotypically examined the gene deletion and overexpression mutants of atnN and studied the secondary metabolite production of the mutants. Overexpression of atnN significantly reduced the colony growth of surface cultures compared to the control. The ΔatnN gene deletion strain showed higher sensitivity to tert-butyl hydroperoxide (tBOOH), while the atnNOE strain was more resistant to MSB, Congo Red, and sorbitol. Interestingly, deletion of atnN decreased cleistothecia formation of A. nidulans. Manipulation of atnN affected the synthesis of several secondary metabolites, for example, the siderophore production of A. nidulans. The extracellular triacetylfusarinine C (TAFC) production decreased, while the intracellular ferricrocin (FC) concentration of the cultures increased in the atnNOE mutant cultivating A. nidulans in a complex medium containing 1 % mycological peptone and 2 % maltose. In Czapek-Dox Broth medium, increased asperthecin production was observed in the ΔatnN mutant. The mycotoxin sterigmatocystin synthesis elevated in the ΔatnN mutant, while reduced in the atnNOE mutant on minimal medium. Our study supports previous observations that secondary metabolite production is coordinated in a complex way, and the linkage of stress response, sexual reproduction, and secondary metabolite production can be governed by several transcription factors. 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(DE / TTK / BiotechI); Növényszervezettani Tanszék (ELTE / TTK / Bio_I); Szervetlen és Analitikai Kémiai Tanszék (DE / TTK / KemI) 8 44 6 8 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 121638840 /api/authorship/121638840 1 0.125 true false false Author 10079544 /api/author/10079544 Kocsis Beatrix true true Kocsis Beatrix true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121638841 /api/authorship/121638841 2 0.125 false false false Author 10020703 /api/author/10020703 Boldizsár Imre true 10020703 true Boldizsár Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121638842 /api/authorship/121638842 3 0.125 false false false Author 10001140 /api/author/10001140 Kovács M. Gábor true 10001140 true Kovács Gábor M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121638843 /api/authorship/121638843 4 0.125 false false false Author 10038159 /api/author/10038159 Nagy Tibor true 10038159 true Nagy Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121638844 /api/authorship/121638844 5 0.125 false false false Author 10002900 /api/author/10002900 Gyémánt Gyöngyi true 10002900 true Gyémánt Gyöngyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121638845 /api/authorship/121638845 6 0.125 false false false Author 10030864 /api/author/10030864 Csillag Kinga Karola true 10030864 true Csillag Kinga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121638846 /api/authorship/121638846 7 0.125 false false false Author 10013928 /api/author/10013928 Pócsi István true 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true /api/publication/35576719 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10079544"><a href="/gui2/?type=authors&mode=browse&sel=10079544" target="_blank">Kocsis Beatrix (<span class="authorship-author-name">Kocsis Beatrix</span> <span class="authorAux-mtmt"> Molekuláris biológia (mikrobiológia)</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/HUN-REN-DE Fungal Stress Biology Research Group; <span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/<span title="Biotechnológiai Intézet">BiotechI</span>/Molekuláris Biotechnológiai és Mikrobiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020703"><a href="/gui2/?type=authors&mode=browse&sel=10020703" target="_blank">Boldizsár Imre (<span class="authorship-author-name">Boldizsár Imre</span> <span class="authorAux-mtmt"> Farmakobotanika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacognosy; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of of Plant Anatomy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001140"><a href="/gui2/?type=authors&mode=browse&sel=10001140" target="_blank">Kovács Gábor M. (<span class="authorship-author-name">Kovács M. Gábor</span> <span class="authorAux-mtmt"> Mikológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of of Plant Anatomy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038159"><a href="/gui2/?type=authors&mode=browse&sel=10038159" target="_blank">Nagy Tibor (<span class="authorship-author-name">Nagy Tibor</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/<span title="Institute of Chemistry">IChem</span>/Department of Applied Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002900"><a href="/gui2/?type=authors&mode=browse&sel=10002900" target="_blank">Gyémánt Gyöngyi (<span class="authorship-author-name">Gyémánt Gyöngyi</span> <span class="authorAux-mtmt"> Kromatográfia, biokémia, szénhidrátkémia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/<span title="Institute of Chemistry">IChem</span>/Department of Inorganic and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030864"><a href="/gui2/?type=authors&mode=browse&sel=10030864" target="_blank">Csillag Kinga (<span class="authorship-author-name">Csillag Kinga Karola</span> <span class="authorAux-mtmt"> szintetikus szerves kémiai</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/<span title="Biotechnológiai Intézet">BiotechI</span>/Molekuláris Biotechnológiai és Mikrobiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013928"><a href="/gui2/?type=authors&mode=browse&sel=10013928" target="_blank">Pócsi István (<span class="authorship-author-name">Pócsi István</span> <span class="authorAux-mtmt"> Mikrobiológia, biotechnológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/HUN-REN-DE Fungal Stress Biology Research Group; <span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/<span title="Biotechnológiai Intézet">BiotechI</span>/Molekuláris Biotechnológiai és Mikrobiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014643"><a href="/gui2/?type=authors&mode=browse&sel=10014643" target="_blank">Leiter Éva ✉ (<span class="authorship-author-name">Leiter Éva Juliánna</span> <span class="authorAux-mtmt"> Mikrobiológia, mikológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/HUN-REN-DE Fungal Stress Biology Research Group; <span title="University of Debrecen">UD</span>/<span title="Faculty of Science and Technology">Faculty of Science and Technology</span>/<span title="Biotechnológiai Intézet">BiotechI</span>/Molekuláris Biotechnológiai és Mikrobiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35576719" target="_blank">Could the transcription factor AtnN coordinating the aspercryptin secondary metabolite gene cluster in Aspergillus nidulans be a global regulator?</a></div> <div> <span class="journal-title">FUNGAL BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1878-6146">1878-6146</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1878-6162">1878-6162</a>)</span>: <span class="journal-volume">128</span> <span class="journal-issue">8</span> <span class="page"> pp 2311-2316 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.funbio.2024.11.006" target="_blank" href="https://doi.org/10.1016/j.funbio.2024.11.006"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="382220" target="_blank" href="http://hdl.handle.net/2437/382220"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001359256100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001359256100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85208768103" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85208768103"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="39643398" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39643398&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://linkinghub.elsevier.com/retrieve/pii/S1878614624001454" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S1878614624001454"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Plant Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Genetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Infectious Diseases&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 2 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35576719&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35576719</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Szekunder metabolit génklaszterek aktiválása Aspergillus nidulansban és Fusarium verticillioidesb...(K 119494) Funder: NRDIO, (K127931) Funder: NKFIH, Növények és endofiton gombáik másodlagos anyagcseretermékeinek vizsgálata – metabolikus diverzitá...(K 135712) Funder: NRDI Office, Biotechnológia(TKP2021-EGA-20) Funder: MIT </div> <div class="lastModified">Last Modified: 2024.12.11. 10:51 Zsuzsa Ágnes Vida (DE/ÁOK/ElettI Admin 5, admin) </div> <div class="lockedBy">Centrally managed 2025.06.02. 20:20 Andrea Vándor (VA, admin) </div> </div></div>