https://m2.mtmt.hu/ eng 2026-05-25 22:44 JournalArticle 35501912 VALIDATED true 0 false 2026-05-24T07:50:05.020+0000 2024-11-28T06:15:12.171+0000 2024-11-06T09:30:57.391+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2024-11-21T08:46:09.124+0000 2024-11-28T06:15:12.178+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:11.680+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Barreca, Marco Development and validation of a gene expression-based Breast Cancer Purity Score true true /api/journal/10082889 REVIEWED true false 10082889 false 10082889 true 2397-768X Journal FOREIGN 8 1 242 242 11 2024 The prevalence of malignant cells in clinical specimens, or tumour purity, is affected by both intrinsic biological factors and extrinsic sampling bias. Molecular characterization of large clinical cohorts is typically performed on bulk samples; data analysis and interpretation can be biased by tumour purity variability. Transcription-based strategies to estimate tumour purity have been proposed, but no breast cancer specific method is available yet. We interrogated over 6000 expression profiles from 10 breast cancer datasets to develop and validate a 9-gene Breast Cancer Purity Score (BCPS). BCPS outperformed existing methods for estimating tumour content. Adjusting transcriptomic profiles using the BCPS reduces sampling bias and aids data interpretation. BCPS-estimated tumour purity improved prognostication in luminal breast cancer, correlated with pathologic complete response in on-treatment biopsies from triple-negative breast cancer patients undergoing neoadjuvant treatment and effectively stratified the risk of relapse in HER2+ residual disease post-neoadjuvant treatment. 2024 true true true false false GOLD 2026-05-24 true https://doi.org/10.1038/s41698-024-00730-7 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 0 0 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 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true true PublicationIdentifier 27763120 /api/publicationidentifier/27763120 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39448787 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39448787&dopt=Abstract false true SjrRating 11488729 /api/sjrrating/11488729 32 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true D1 DIRECT true true /api/publication/35501912 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Barreca Marco </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dugo Matteo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galbardi Barbara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Valagussa Pinuccia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Besozzi Daniela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Viale Giuseppe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianchini Giampaolo ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gianni Luca ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Callari Maurizio ✉ </span> </div> <div class="autype autype-11"> Collaborator: <span class="author-name" >Gianni Luca </span> ;&nbsp;&nbsp;&nbsp; et al. (51) </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-affil">NA-PHER2 consortium</span> ;&nbsp;&nbsp;&nbsp; <span class="author-affil">NeoTRIP consortium</span> </div> <div><a target="_blank" href="/api/publication/35501912?labelLang=eng">All authors</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35501912" target="_blank">Development and validation of a gene expression-based Breast Cancer Purity Score</a></div> <div> <span class="journal-title">NPJ PRECISION ONCOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2397-768X">2397-768X</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper 242. 11 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41698-024-00730-7" target="_blank" href="https://doi.org/10.1038/s41698-024-00730-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001340683600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001340683600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85207837271" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207837271"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39448787" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39448787&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 0 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35501912</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Study Group ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2024.11.28. 07:15 Róbert Milánkovics (PTE ÁOK admin 4) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> </div></div>