https://m2.mtmt.hu/ hun 2026-09-22 16:40 JournalArticle 35485976 VALIDATED true Funding Agency and Grant Number: Semmelweis University [RF1AG072295, R01AG055395, R01AG068295, R01AG070915]; National Institute on Aging [R01NS100782]; National Institute of Neurological Disorders and Stroke [R01CA255840, TKP2021-NKTA-47]; National Cancer Institute [135784, 129277]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [RRF-2.3.1-21-2022-00003]; National Cardiovascular Laboratory Program; National Research, Development and Innovation Fund of Hungary [101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1]; European University for Well-Being (EUniWell) program Funding text: This work was supported by grants from the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915), the National Institute of Neurological Disorders and Stroke (R01NS100782), and the National Cancer Institute (R01CA255840). TC was supported by TKP2021-NKTA-47, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NKTA funding scheme, by funding through the National Cardiovascular Laboratory Program (RRF-2.3.1-21-2022-00003) provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, Project no. 135784 and 129277 implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the K20 funding scheme and the European University for Well-Being (EUniWell) program (grant agreement number: 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1). The 4.0 version of ChatGPT, developed by OpenAI, was used as a language tool to refine our writing, enhancing the clarity of our work. 0 false 2026-07-30T10:56:16.478+0000 2026-06-15T12:38:39.373+0000 2024-10-29T21:24:27.935+0000 true 10095290 Kubicsek Ferenc /api/admin/10095290 Admin true 2026-07-09T11:23:14.336+0000 2026-01-12T08:26:12.904+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2026-06-15T12:38:39.748+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Czinege, Zsófia Understanding perioperative risk determinants in carotid endarterectomy: the impact of compromised circle of Willis morphology on inter-hemispheric blood flow indices based on intraoperative internal carotid artery stump pulse pressure and backflow patterns true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 2 2159 2177 2159 19 2025 Carotid artery stenosis (CAS) often requires surgical intervention through carotid endarterectomy (CEA) to prevent stroke. Accurate cerebrovascular risk assessments are crucial in CEA, as poor collateral circulation can lead to insufficient interhemispheric blood flow compensation, resulting in ischemic complications. Therefore, understanding perioperative risk determinants is vital. This study aims to determine the impact of compromised circle of Willis (CoW) morphology on inter-hemispheric blood flow, focusing on indices based on intraoperative internal carotid artery stump pulse pressure and backflow patterns. In 80 CAS patients who underwent CEA, preoperative CT angiography for CoW was conducted. Patients were categorized into five subgroups based on their CoW anatomy and three additional groups based on intraoperative internal carotid artery (ICA) stump backflow patterns evaluated by the surgeon. Continuous blood pressure signals, including systolic, diastolic, mean, and pulse pressure values, were recorded during the procedure. The relationship between CoW anatomical variants and the systolic and diastolic segments of the averaged pressure waveforms, particularly diastolic pressure decay, was analyzed. The correlation between CoW anatomy and stump backflow intensity was also examined. Significant variability in ICA stump backflow and pressure values was evident across CoW variants. Patients with compromised CoW morphology exhibited weaker backflow patterns and lower ICA stump pulse pressure values, consistent with impaired interhemispheric blood flow. Notably, ICA stump diastolic pressure decay was consistent across most CoW variant groups, indicating developed collateral circulation in cases with CoW anomalies. Thus, impaired CoW integrity is associated with compromised interhemispheric blood flow indices based on intraoperative ICA stump pulse pressure and backflow patterns during CEA. Integrating intraoperative pulse waveform analysis with preoperative CT angiography provides a more detailed assessment of cerebrovascular risk, guiding the selective use of shunts. This combined approach may improve surgical outcomes and patient safety by identifying patients at increased risk of perioperative neurological events due to CoW anomalies. 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false false false Author 10076550 /api/author/10076550 Sándor Ágnes Dóra true true Sándor Ágnes Dóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091301 /api/authorship/121091301 3 0.1 false false false Author 10063392 /api/author/10063392 Gyürki Dániel László true 10063392 true Gyürki Dániel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091302 /api/authorship/121091302 4 0.1 false false false Author 10068175 /api/author/10068175 Varga Andrea true true Varga Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091303 /api/authorship/121091303 5 0.1 false false false Author 10055259 /api/author/10055259 Csípő Tamás true 10055259 true Csípő Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091304 /api/authorship/121091304 6 0.1 false false false Author 10021986 /api/author/10021986 Székely Andrea true 10021986 true Székely Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091305 /api/authorship/121091305 7 0.1 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvári Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091306 /api/authorship/121091306 8 0.1 false false false Author 10035762 /api/author/10035762 Banga Péter true 10035762 true Banga Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091307 /api/authorship/121091307 9 0.1 false true Author 10011801 /api/author/10011801 Sótonyi Péter true 10011801 true Sótonyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121091308 /api/authorship/121091308 10 0.1 false true false Author 10025180 /api/author/10025180 Horváth 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10069726"><a href="/gui2/?type=authors&mode=browse&sel=10069726" target="_blank">Czinege Zsófia ✉ (<span class="authorship-author-name">Czinege Zsófia</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Érsebészeti és Endovaszkuláris Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076550"><a href="/gui2/?type=authors&mode=browse&sel=10076550" target="_blank">Sándor Ágnes Dóra (<span class="authorship-author-name">Sándor Ágnes Dóra</span> <span class="authorAux-mtmt"> Agyi oxigenizáció monitorozása, kognitív funkci...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063392"><a href="/gui2/?type=authors&mode=browse&sel=10063392" target="_blank">Gyürki Dániel (<span class="authorship-author-name">Gyürki Dániel László</span> <span class="authorAux-mtmt"> hidrodinamika</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Gépészmérnöki Kar">GPK</span>/Hidrodinamikai Rendszerek Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068175"><a href="/gui2/?type=authors&mode=browse&sel=10068175" target="_blank">Varga Andrea (<span class="authorship-author-name">Varga Andrea</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Intervenciós Radiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csípő Tamás (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021986"><a href="/gui2/?type=authors&mode=browse&sel=10021986" target="_blank">Székely Andrea (<span class="authorship-author-name">Székely Andrea</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia, szívsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvári Zoltán (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035762"><a href="/gui2/?type=authors&mode=browse&sel=10035762" target="_blank">Banga Péter (<span class="authorship-author-name">Banga Péter</span> <span class="authorAux-mtmt"> Érsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Érsebészeti és Endovaszkuláris Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011801"><a href="/gui2/?type=authors&mode=browse&sel=10011801" target="_blank">Sótonyi Péter<sup>**</sup> (<span class="authorship-author-name">Sótonyi Péter</span> <span class="authorAux-mtmt"> Érsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Érsebészeti és Endovaszkuláris Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025180"><a href="/gui2/?type=authors&mode=browse&sel=10025180" target="_blank">Horváth Tamás (<span class="authorship-author-name">Horváth Tamás</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Sportélettani Kutató Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35485976" target="_blank">Understanding perioperative risk determinants in carotid endarterectomy: the impact of compromised circle of Willis morphology on inter-hemispheric blood flow indices based on intraoperative internal carotid artery stump pulse pressure and backflow patterns</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">2</span> <span class="page"> pp 2159-2177 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-024-01390-y" target="_blank" href="https://doi.org/10.1007/s11357-024-01390-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001342058200002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001342058200002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85207363319" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207363319"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39460849" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39460849&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 6 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35485976&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35485976</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (TKP2021-NKTA-47), (RRF-2.3.1-21-2022-00003), (135784) Támogató: NKFIH, (K129277) Támogató: NKFI, (101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1), TKP2021-EGA-37(TKP2021-EGA-37) </div> <div class="lastModified">Utolsó módosítás: 2026.06.15. 14:38 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis University [RF1AG072295, R01AG055395, R01AG068295, R01AG070915]; National Institute on Aging [R01NS100782]; National Institute of Neurological Disorders and Stroke [R01CA255840, TKP2021-NKTA-47]; National Cancer Institute [135784, 129277]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [RRF...</pre> </div></div>