Sustained drug-free remission in rheumatoid arthritis associated with diffuse large
B-cell lymphoma following tandem CD20-CD19-directed non-cryopreserved CAR-T cell therapy
using zamtocabtagene autoleucel
Immunbetegségek biológiai alapjai (pl. autoimmunitás)
We report the case of long-term persisting rheumatoid arthritis (RA), treated with
CD20-CD19 CAR-T when it became associated with diffuse large B cell lymphoma (DLBCL),
resulting in a sustained drug-free remission of the preceding RA, as well as of the
subsequent DLBCL that formed the indication of the CAR-T therapy using zamtocabtagene
autoleucel, with a 1-year follow-up. According to our best knowledge, this is the
first published clinical case report of long-term persisting RA treated with CAR-T
cell therapy.
