https://m2.mtmt.hu/ eng 2026-10-23 22:01 JournalArticle 35484229 VALIDATED true 0 false 2026-10-09T16:49:42.054+0000 2026-06-18T15:03:31.976+0000 2024-10-29T10:05:37.739+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Márta Molnár-Taga (SE 4-es admin) true 10062250 2026-06-18T17:19:14.059+0000 2024-12-06T18:10:30.335+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Lőczi, Lotti Lúcia true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 13 20 6131 6131 15 2024 Background: Vulvovaginal atrophy (VVA) significantly impacts the quality of life in breast cancer patients leading to symptoms like vaginal dryness, dyspareunia, and genital discomfort. Quality of life in this context is measured using validated scales like the Vaginal Health Index, Visual Analog Scale (VAS), and the Female Sexual Function Index (FSFI). Methods: We performed a systematic review and meta-analysis to identify effective treatment options for VVA, including topical estrogen, systemic hormone therapy, vaginal DHEA, ospemifene, and non-hormonal methods like intravaginal laser therapy, moisturizers, and lubricants. A systematic search of four databases (MEDLINE, Scopus, CENTRAL, Embase) identified studies on VVA treatment efficacy in breast cancer patients, yielding 13,039 records, with 32 eligible studies and 8 included in the meta-analysis. Results: Significant improvements were found with intravaginal laser therapy, showing notable differences in the Vaginal Health Index (MD = 8.24, p < 0.01), dyspareunia (MD = -4.82, p = 0.05), and dryness (MD = -5.05, p = 0.01). However, no significant changes were observed in FSFI and vaginal pH. Notably only intravaginal laser therapy was included in the meta-analysis, as other treatment options lacked comparable data. Both hormonal and non-hormonal treatments improved quality of life, with laser therapy showing the most substantial effects. Conclusions: Intravaginal laser therapy is an effective treatment for VVA symptoms in breast cancer survivors, particularly in improving the Vaginal Health Index and reducing dyspareunia. Despite the strengths of the study, variability among studies, lack of RCT-s and data limitations, especially on long-term effects, present challenges. true true 2024 true true true false true false GOLD 2026-10-09 true https://doi.org/10.3390/jcm13206131 6 0 6 6 0 6 6 5 4 5 5 5 5 6 0 0 6 6 6 6 0 2 2 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 2 2 2 2 2026 0 4 4 4 4 Q1 false false false false 2024-10-28T10:05:44.210+0000 Doktori Iskola (SE); Intenzív Terápiás Klinika (SE / AOK / K); Pankreász Betegségek Intézete (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 10 42 7 12 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 121084413 /api/authorship/121084413 Lőczi, Lotti Lúcia [Keszthelyi, Lotti Lúcia (Szülészet, nőgyóg...), author] Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG); Centre for Translational Medicine (SU / KSZE) 1 0.083 true false false Author 10092560 /api/author/10092560 Lotti Lúcia Keszthelyi (Szülészet, nőgyógyászat) Keszthelyi Lotti Lúcia true true Lőczi Lotti Lúcia true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084414 /api/authorship/121084414 Vleskó, Gábor* [Vleskó, Gábor (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG); Centre for Translational Medicine (SU / KSZE) 2 0.083 true false false Author 10023908 /api/author/10023908 Gábor Vleskó (Szülészet-nőgyógyászat) Vleskó Gábor true 10023908 true Vleskó Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084415 /api/authorship/121084415 Éliás, Máté [Éliás, Máté (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 3 0.083 false false false Author 10094592 /api/author/10094592 Máté Éliás (Szülészet-nőgyógyászat) Éliás Máté true true Éliás Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084416 /api/authorship/121084416 Turan, Caner [Turan, Caner (Anesthesia and In...), author] Intensive Care Clinic (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 4 0.083 false false false Author 10077662 /api/author/10077662 Caner Turan (Anesthesia and Intensive Care) Turan Caner true true Turan Caner true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084417 /api/authorship/121084417 Kajtár, Panna 5 0.083333336 false false false Kajtár Panna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084418 /api/authorship/121084418 Tóth, Réka 6 0.083333336 false false false Tóth Réka true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084419 /api/authorship/121084419 Sipos, Miklós [Sipos, Miklós (asszisztált repro...), author] Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG); Centre for Translational Medicine (SU / KSZE) 7 0.083 false false false Author 10077450 /api/author/10077450 Miklós Sipos (asszisztált reprodukció) Sipos Miklós true true Sipos Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084420 /api/authorship/121084420 Nagy, Rita [Nagy, Rita (Gyermekgyógyászat), author] Centre for Translational Medicine (SU / KSZE) 8 0.083 false false false Author 10081469 /api/author/10081469 Rita Nagy (Gyermekgyógyászat) Nagy Rita true true Nagy Rita true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084421 /api/authorship/121084421 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute of Pancreatic Diseases (SU / FM / C); Centre for Translational Medicine (SU / KSZE); Institute for Translational Medicine (UP / UPMS) 9 0.083 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084422 /api/authorship/121084422 Ács, Nándor [Ács, Nándor (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG); Centre for Translational Medicine (SU / KSZE) 10 0.083 false false false Author 10013998 /api/author/10013998 Nándor Ács (Szülészet-nőgyógyászat) Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084423 /api/authorship/121084423 Várbíró, Szabolcs [Várbíró, Szabolcs (Keringésélettan), author] School of PhD Studies (SU); Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG); Centre for Translational Medicine (SU / KSZE) 11 0.083 false false false Author 10011316 /api/author/10011316 Szabolcs Várbíró (Keringésélettan) Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121084424 /api/authorship/121084424 Keszthelyi, Márton ✉ [Keszthelyi, Márton (Szülészet-nőgyógy...), author] Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG); Centre for Translational Medicine (SU / KSZE) 12 0.083 false true true Author 10072753 /api/author/10072753 Márton Keszthelyi (Szülészet-nőgyógyászat) Keszthelyi Márton true true Keszthelyi Márton true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 27707475 /api/publicationidentifier/27707475 DOI: 10.3390/jcm13206131 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcm13206131 https://doi.org/10.3390/jcm13206131 false true PublicationIdentifier 27779222 /api/publicationidentifier/27779222 WoS: 001342260900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001342260900001 https://www.webofscience.com/wos/woscc/full-record/001342260900001 false true PublicationIdentifier 27783968 /api/publicationidentifier/27783968 Scopus: 85207598135 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85207598135 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207598135 true true PublicationIdentifier 27707474 /api/publicationidentifier/27707474 PubMed: 39458081 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39458081 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39458081&dopt=Abstract false true Classification 12215 /api/classification/12215 Clinical medicine true true Classification 12217 /api/classification/12217 Obstetrics and gynaecology true true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11482758 /api/sjrrating/11482758 sjr:Q1 (2024) Scopus - Medicine (miscellaneous) JOURNAL OF CLINICAL MEDICINE 2077-0383 607 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q1 DIRECT true true /api/publication/35484229 Lőczi Lotti Lúcia et al. Effect of Vaginal Laser and Topical Therapies on Vulvovaginal Atrophy Symptoms in Breast Cancer Patients : A Systematic Review and Meta-Analysis. (2024) JOURNAL OF CLINICAL MEDICINE 2077-0383 13 20<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10092560"><a href="/gui2/?type=authors&mode=browse&sel=10092560" target="_blank">Lőczi Lotti Lúcia (<span class="authorship-author-name">Keszthelyi Lotti Lúcia</span> <span class="authorAux-mtmt"> Szülészet, nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023908"><a href="/gui2/?type=authors&mode=browse&sel=10023908" target="_blank">Vleskó Gábor^* (<span class="authorship-author-name">Vleskó Gábor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094592"><a href="/gui2/?type=authors&mode=browse&sel=10094592" target="_blank">Éliás Máté (<span class="authorship-author-name">Éliás Máté</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077662"><a href="/gui2/?type=authors&mode=browse&sel=10077662" target="_blank">Turan Caner (<span class="authorship-author-name">Turan Caner</span> <span class="authorAux-mtmt"> Anesthesia and Intensive Care</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Intensive Care Clinic; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kajtár Panna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóth Réka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077450"><a href="/gui2/?type=authors&mode=browse&sel=10077450" target="_blank">Sipos Miklós (<span class="authorship-author-name">Sipos Miklós</span> <span class="authorAux-mtmt"> asszisztált reprodukció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081469"><a href="/gui2/?type=authors&mode=browse&sel=10081469" target="_blank">Nagy Rita (<span class="authorship-author-name">Nagy Rita</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072753"><a href="/gui2/?type=authors&mode=browse&sel=10072753" target="_blank">Keszthelyi Márton ✉ (<span class="authorship-author-name">Keszthelyi Márton</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35484229" target="_blank">Effect of Vaginal Laser and Topical Therapies on Vulvovaginal Atrophy Symptoms in Breast Cancer Patients : A Systematic Review and Meta-Analysis</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">20</span> <span class="page"> Paper 6131. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm13206131" target="_blank" href="https://doi.org/10.3390/jcm13206131"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001342260900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001342260900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85207598135" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207598135"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39458081" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39458081&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 6 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;4 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35484229&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35484229</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2026.06.18. 17:03 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>