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      <abstractText>Bevezetés: A szájüregi potenciálisan rosszindulatú elváltozások közül az egyik leggyakoribb lézió a leukoplakia. Fontostisztázni, hogy a klinikailag leukoplakiának diagnosztizált esetek mögött milyen hisztopatológiai diagnózis áll, amely döntőenmeghatározza a prognózist és a szükséges terápiát.Anyag és módszer: 2021. április és 2024. április között 75 szájüregi leukoplakiával diagnosztizált betegnél történt szövettanimintavétel a Semmelweis Egyetem Orális Diagnosztikai Tanszék Dento-alveolaris Sebészeti Osztályán. A szövettaniminták hisztopatológiai elemzése hematoxilin-eozin festett minták alapján történt a Semmelweis Egyetem Patológiaiés Kísérleti Rákkutató Intézetében, bizonyos esetekben immunhisztokémiai vizsgálattal kiegészítve.Eredmények és megbeszélés: A 75 betegnél a leukoplakiák előfordulási helye, gyakoriság szerinti csökkenő sorrendben:gingiva/fogatlan állcsontgerinc (n = 26), bucca (n = 16), szájfenék (n = 12), nyelv (n = 11), szájpad (n = 6), ajak (n = 2).Ritka esetben multifocalis megjelenés is előfordult (n = 2). A szövettani mintavétel általában próba excisio volt, nem történtmeg az elváltozás teljes kimetszése. A hisztopatológiai eredmény 51 esetben hyperkeratosis (dysplasia nélkül),19 esetben enyhe dysplasia, 5 esetben mérsékelt dysplasia volt. Súlyos dysplasiás eset nem volt. Klinikai homogenitásttekintve 61 esetben homogén és 14 esetben non-homogén volt a leukoplakia. A nem dysplasiás és dysplasiás betegcsoportokattekintve szignifikánsan gyakrabban állt dysplasia az elváltozás mögött, amennyiben klinikailag non-homogénmegjelenést mutatott a leukoplakia (p = 0,0088). A vizsgált beteganyagon 75 beteg közül 32 dohányzik, 43 nem dohányzik.Eredményeink alapján a dohányzás nem volt szignifikáns hatással a dysplasia jelenlétére és súlyosságára.A betegek követése folyamatos (félévenkénti kontrollvizsgálat). Átlagos követési idő: 17,4 hónap (tartomány: 1–38 hónap).Következtetés: A szájüregi leukoplakiával diagnosztizált betegek esetében szövettani mintavétel szükséges a hisztopatológiaidiagnózis felállításához, valamint hosszú távú követés javasolt a késői rosszindulatú átalakulás elkerülésére.</abstractText>
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