https://m2.mtmt.hu/ hun 2026-09-21 15:33 JournalArticle 35473330 VALIDATED true Juhasz G and Bagdy Gy authors contributed equally to this work. 0 false 2026-08-31T12:12:39.569+0000 2025-09-02T07:53:15.411+0000 2024-10-22T08:40:36.047+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2026-07-07T10:44:49.260+0000 2025-09-02T07:53:15.648+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Gál, Zsófia true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 20 11332 11332 17 2024 Mounting evidence supports the key role of the disrupted integrity of the blood-brain barrier (BBB) in stress- and inflammation-associated depression. We assumed that variations in genes regulating the expression and coding proteins constructing and maintaining this barrier, along with those involved in inflammation, have a predisposing or protecting role in the development of depressive symptoms after experiencing severe stress. To prove this, genome-by-environment (GxE) interaction analyses were conducted on 6.26 M SNPS covering 19,296 genes on PHQ9 depression in interaction with adult traumatic events scores in the UK Biobank (n = 109,360) in a hypothesis-free setup. Among the 63 genes that were significant in stress-connected depression, 17 were associated with BBB, 23 with inflammatory processes, and 4 with neuroticism. Compared to all genes, the enrichment of significant BBB-associated hits was 3.82, and those of inflammation-associated hits were 1.59. Besides some sex differences, CSMD1 and PTPRD, encoding proteins taking part in BBB integrity, were the most significant hits in both males and females. In conclusion, the identified risk genes and their encoded proteins could provide biomarkers or new drug targets to promote BBB integrity and thus prevent or decrease stress- and inflammation-associated depressive symptoms, and possibly infection, e.g., COVID-19-associated mental and neurological symptoms. 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NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 7 35 3 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 121031353 /api/authorship/121031353 Gál, Zsófia [Gál, Zsófia (neurobiológia, ps...), szerző] Gyógyszerhatástani Intézet (SE / GYTK); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS) 1 0.111 true false false Author 10067900 /api/author/10067900 Gál Zsófia (neurobiológia, pszichiátriai genetika) Gál Zsófia true true Gál Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121031354 /api/authorship/121031354 Török, Dóra [Török, Dóra (pszichiátriai gen...), szerző] Gyógyszerhatástani Intézet (SE / GYTK); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS) 2 0.111 false false false Author 10075294 /api/author/10075294 Török Dóra (pszichiátriai genetika) Török Dóra true true Török Dóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121031355 /api/authorship/121031355 Gonda, Xénia [Gonda, Xénia (Pszichiátria, psz...), szerző] NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); 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NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS) 7 0.111 false false false Author 10024138 /api/author/10024138 Petschner Péter (Farmakológia) Petschner Péter true 10024138 true Petschner Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121031360 /api/authorship/121031360 Juhász, Gabriella** [Juhász, Gabriella (Neurológia), szerző] Gyógyszerhatástani Intézet (SE / GYTK); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS) 8 0.111 false true false Author 10017483 /api/author/10017483 Juhász Gabriella (Neurológia) Juhász Gabriella true 10017483 true Juhász Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121031361 /api/authorship/121031361 Bagdy, György ✉ [Bagdy, György (Neuropszichofarma...), szerző] Gyógyszerhatástani Intézet (SE / GYTK); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS) 9 0.111 false true true Author 10001318 /api/author/10001318 Bagdy György (Neuropszichofarmakológia, gyógyszertan) Bagdy György true 10001318 true Bagdy György true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 27678181 /api/publicationidentifier/27678181 DOI: 10.3390/ijms252011332 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms252011332 https://doi.org/10.3390/ijms252011332 false true PublicationIdentifier 27758377 /api/publicationidentifier/27758377 WoS: 001341757000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001341757000001 https://www.webofscience.com/wos/woscc/full-record/001341757000001 true true PublicationIdentifier 27758366 /api/publicationidentifier/27758366 Scopus: 85207464047 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85207464047 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207464047 true true PublicationIdentifier 27758371 /api/publicationidentifier/27758371 PubMed: 39457114 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39457114 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39457114&dopt=Abstract true true Classification 12197 /api/classification/12197 Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés true true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 58989197 /api/reference/58989197 1. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 20<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067900"><a href="/gui2/?type=authors&mode=browse&sel=10067900" target="_blank">Gál Zsófia (<span class="authorship-author-name">Gál Zsófia</span> <span class="authorAux-mtmt"> neurobiológia, pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075294"><a href="/gui2/?type=authors&mode=browse&sel=10075294" target="_blank">Török Dóra (<span class="authorship-author-name">Török Dóra</span> <span class="authorAux-mtmt"> pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xénia (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045710"><a href="/gui2/?type=authors&mode=browse&sel=10045710" target="_blank">Eszlári Nóra (<span class="authorship-author-name">Eszlári Nóra</span> <span class="authorAux-mtmt"> Pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anderson Ian Muir </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deakin Bill </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024138"><a href="/gui2/?type=authors&mode=browse&sel=10024138" target="_blank">Petschner Péter (<span class="authorship-author-name">Petschner Péter</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017483"><a href="/gui2/?type=authors&mode=browse&sel=10017483" target="_blank">Juhász Gabriella^** (<span class="authorship-author-name">Juhász Gabriella</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy György ✉ (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35473330" target="_blank">New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">20</span> <span class="page"> Paper 11332. 17 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms252011332" target="_blank" href="https://doi.org/10.3390/ijms252011332"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001341757000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001341757000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85207464047" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207464047"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39457114" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39457114&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 4 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35473330&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35473330</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (2019-2.1.7-ERA-NET-2020-00005) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, ERA PerMed(ERAPERMED2019-108), (K 143391), (K139330), (PD 146014), (PD134449), National Brain Programme(NAP2022-I-4/2022 3.0), (TKP2021-EGA-25), (TKP2021-EGA-02) Támogató: NKFIH, (János Bolyai Research Scholarship) </div> <div class="lastModified">Utolsó módosítás: 2025.09.02. 09:53 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Juhasz G and Bagdy Gy authors contributed equally to this work.</pre> </div></div>