https://m2.mtmt.hu/ eng 2026-07-26 18:02 JournalArticle 35461306 VALIDATED true 0 false 2026-06-14T23:06:43.343+0000 2024-10-31T06:19:25.263+0000 2024-10-16T05:29:27.036+0000 true 10097449 Bodnár Barbara /api/admin/10097449 Admin true 2024-11-12T09:21:05.927+0000 2024-11-11T13:04:34.379+0000 true 569 Balázs András /api/admin/569 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:00:28.482+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Massey, Luke A. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy true true /api/journal/3283 REVIEWED true false 3283 false 3283 true 0885-3185 1531-8257 Journal FOREIGN 27 14 1755 1762 1755 8 2012 Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P < .001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy. 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/api/authorship/120944824 10 0.071428575 false false false Burn David J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944825 /api/authorship/120944825 11 0.071428575 false false false Yousry Tarek true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944826 /api/authorship/120944826 12 0.071428575 false false false Lees Andrew J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944827 /api/authorship/120944827 13 0.071428575 false false false Fox Nick C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944828 /api/authorship/120944828 14 0.071428575 false true false Jaeger Hans R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 27649676 /api/publicationidentifier/27649676 PlainSource 6 /api/publicationsource/6 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/api/keyword/1723293 true true Keyword 2133428 /api/keyword/2133428 true true Keyword 3607415 /api/keyword/3607415 true true Keyword 3607416 /api/keyword/3607416 true true SjrRating 5667058 /api/sjrrating/5667058 26 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 true 2728 true D1 DIRECT true 5667058 true /api/publication/35461306 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Massey Luke A. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Micallef Caroline </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Paviour Dominic C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >O'Sullivan Sean S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ling Helen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Williams David R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kallis Constantinos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Holton Janice L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10097351"><a href="/gui2/?type=authors&mode=browse&sel=10097351" target="_blank">Revesz Tamas (<span class="authorship-author-name">Révész Tamás</span> <span class="authorAux-mtmt"> Neuropathológia - klinikai idegtudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Burn David J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yousry Tarek </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lees Andrew J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fox Nick C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jaeger Hans R. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35461306" target="_blank">Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy</a></div> <div> <span class="journal-title">MOVEMENT DISORDERS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0885-3185">0885-3185</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1531-8257">1531-8257</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">14</span> <span class="page"> pp 1755-1762 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/mds.24968" target="_blank" href="https://doi.org/10.1002/mds.24968"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000314899000012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000314899000012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84871768775" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84871768775"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="22488922" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22488922&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 157</span> | Independent citation: 149 | Self citation: 8 | Unknown citation: 0 | Number of citations in WoS: 157 | Number of citations in Scopus:&nbsp;134 | WoS/Scopus assigned:&nbsp;157 | Number of citations with DOI:&nbsp;155 (Not published:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35461306&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35461306</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2024.10.31. 07:19 Barbara Bodnár (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Centrally managed 2025.01.02. 13:00 Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>