https://m2.mtmt.hu/ eng 2026-07-28 00:56 JournalArticle 35461286 VALIDATED true 0 false 2026-06-16T10:14:37.149+0000 2024-10-31T09:04:08.867+0000 2024-10-16T05:28:44.518+0000 true 10097449 Bodnár Barbara /api/admin/10097449 Admin true 2024-11-12T09:38:05.738+0000 2024-11-08T11:36:23.558+0000 true 569 Balázs András /api/admin/569 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:00:28.482+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ling, H. Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome a cortical variant true true /api/journal/3358 REVIEWED true false 3358 false 3358 true 0305-1846 1365-2990 Journal FOREIGN 40 2 149 163 149 15 2014 AimsSince the first description of the classical presentation of progressive supranuclear palsy (PSP) in 1963, now known as Richardson's syndrome (PSP-RS), several distinct clinical syndromes have been associated with PSP-tau pathology. Like other neurodegenerative disorders, the severity and distribution of phosphorylated tau pathology are closely associated with the clinical heterogeneity of PSP variants. PSP with corticobasal syndrome presentation (PSP-CBS) was reported to have more tau load in the mid-frontal and inferior-parietal cortices than in PSP-RS. However, it is uncertain if differences exist in the distribution of tau pathology in other brain regions or if the overall tau load is increased in the brains of PSP-CBS. MethodsWe sought to compare the clinical and pathological features of PSP-CBS and PSP-RS including quantitative assessment of tau load in 15 cortical, basal ganglia and cerebellar regions. ResultsIn addition to the similar age of onset and disease duration, we demonstrated that the overall severity of tau pathology was the same between PSP-CBS and PSP-RS. We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a cortical' PSP variant. PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups. ConclusionsA better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies. 2024 true true true false false NONE 2026-06-16 false 78 0 78 67 1 78 78 78 67 78 78 67 67 67 11 0 78 67 78 67 0 10 10 Folyóiratcikk Journal Article 24 78 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 4 2 4 2 2015 0 3 1 3 1 2016 0 11 9 11 9 2017 0 5 5 5 5 2018 0 3 2 3 2 2019 0 9 8 9 8 2020 0 6 4 6 4 2021 0 9 8 9 8 2022 0 7 7 7 7 2023 0 7 7 7 7 2024 0 4 4 4 4 2025 0 6 6 6 6 2026 0 4 4 4 4 D1 false false false false 2025-01-14T07:17:41.926+0000 1 1 0 10 0 true 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 120944545 /api/authorship/120944545 1 0.1 true false false Ling H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944546 /api/authorship/120944546 2 0.1 false false false de Silva R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944547 /api/authorship/120944547 3 0.1 false false false Massey L. A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944548 /api/authorship/120944548 4 0.1 false false false Courtney R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944549 /api/authorship/120944549 5 0.1 false false false Hondhamuni G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944550 /api/authorship/120944550 6 0.1 false false false Bajaj N. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944551 /api/authorship/120944551 7 0.1 false false false Lowe J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944552 /api/authorship/120944552 8 0.1 false false false Holton J. L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944553 /api/authorship/120944553 9 0.1 false false false Lees A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944554 /api/authorship/120944554 10 0.1 false true true Author 10097351 /api/author/10097351 Révész Tamás true true Revesz T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 27649625 /api/publicationidentifier/27649625 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1111/nan.12037 https://doi.org/10.1111/nan.12037 false true PublicationIdentifier 27649626 /api/publicationidentifier/27649626 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000331059100006 https://www.webofscience.com/wos/woscc/full-record/000331059100006 false true PublicationIdentifier 27650265 /api/publicationidentifier/27650265 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 84892667945 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84892667945 false true PublicationIdentifier 27649627 /api/publicationidentifier/27649627 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 23432126 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23432126&dopt=Abstract false true Classification 12322 /api/classification/12322 true true Classification 12215 /api/classification/12215 true true Classification 12553 /api/classification/12553 true true Keyword 313 /api/keyword/313 true 313 true Keyword 354 /api/keyword/354 true 354 true Keyword 1023 /api/keyword/1023 true 1023 true Keyword 1107 /api/keyword/1107 true 1107 true Keyword 1084077 /api/keyword/1084077 true 1084077 true Keyword 1129836 /api/keyword/1129836 true 1129836 true Keyword 1199513 /api/keyword/1199513 true 1199513 true Keyword 1493338 /api/keyword/1493338 true true Keyword 1496023 /api/keyword/1496023 true true Keyword 1497845 /api/keyword/1497845 true true Keyword 1599015 /api/keyword/1599015 true true Keyword 1599016 /api/keyword/1599016 true true Keyword 1721073 /api/keyword/1721073 true true Keyword 1721175 /api/keyword/1721175 true true Keyword 2091130 /api/keyword/2091130 true true SjrRating 11083108 /api/sjrrating/11083108 3 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2722 /api/classificationexternal/2722 true 2722 true D1 DIRECT true true /api/publication/35461286 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Ling H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >de Silva R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Massey L. A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Courtney R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hondhamuni G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bajaj N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lowe J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Holton J. L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lees A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10097351"><a href="/gui2/?type=authors&mode=browse&sel=10097351" target="_blank">Revesz T. ✉ (<span class="authorship-author-name">Révész Tamás</span> <span class="authorAux-mtmt"> Neuropathológia - klinikai idegtudomány</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35461286" target="_blank">Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome : a cortical variant.</a></div> <div> <span class="journal-title">NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0305-1846">0305-1846</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1365-2990">1365-2990</a>)</span>: <span class="journal-volume">40</span> <span class="journal-issue">2</span> <span class="page"> pp 149-163 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/nan.12037" target="_blank" href="https://doi.org/10.1111/nan.12037"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000331059100006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000331059100006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84892667945" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84892667945"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="23432126" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23432126&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Histology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 78</span> | Independent citation: 67 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 78 | Number of citations in Scopus:&nbsp;67 | WoS/Scopus assigned:&nbsp;78 | Number of citations with DOI:&nbsp;78 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35461286&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35461286</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2024.10.31. 10:04 Barbara Bodnár (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Centrally managed 2025.01.02. 13:00 Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>