https://m2.mtmt.hu/ hun 2026-09-21 22:49 JournalArticle 35452708 VALIDATED true 0 false 2026-09-07T12:08:26.928+0000 2026-02-20T18:26:08.148+0000 2024-10-13T07:20:40.534+0000 true 10000509 Kőhidai László /api/author/10000509 Author Kőhidai László (Elméleti orvostudomány) true 10000509 2026-02-20T18:26:08.358+0000 2026-02-20T18:26:08.358+0000 2024-11-11T10:34:24.464+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 Admin 10101397 /api/admin/10101397 Tokai Tamás (Központi 2-3, admin) Tokai Tamás true true 2026-01-20T15:16:00.571+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Várhegyi, Vera true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 20 10916 10916 17 2024 There is no literature available about the growth differentiation factor-15 (GDF-15) biomarker in combination with mitochondrial DNA (mtDNA) deletions in insulin resistance (IR), and polycystic ovary syndrome (PCOS); however, it would be useful to achieve optimal metabolic status and improve pregnancy success. In this study, the role of GDF-15 and mtDNA deletions as biomarkers in the pathogenesis of IR and PCOS was investigated. In our study, 81 female patients who were treated for IR and/or PCOS and 41 healthy controls were included. GDF-15 levels in patients showed a marked increase compared to controls. Elevated GDF-15 levels were found in 12 patients; all of them had a BMI > 25 kg/m2, which is associated with reactive hyperinsulinemia. The presence of mitochondrial dysfunction was mainly observed in the IR-only subgroup. The increase in plasma levels of GDF-15 and the prevalence of mtDNA deletions is directly proportional to body mass index. The more marked metabolic abnormalities required more intensive drug therapy with a parallel increase in plasma GDF-15 levels. Elevated levels of GDF-15 and the presence of mitochondrial DNA deletions may be a consequence of carbohydrate metabolism disorders in patients and thus a predictor of the process of accelerated aging. Funding 2045707 /api/funding/2045707 (NKFIH_132812) false true Funding 2045708 /api/funding/2045708 (TKP2021-NVA-15) false true Funding 2045709 /api/funding/2045709 (TKP2021-EGA-25) false true Funding 2045710 /api/funding/2045710 (Hungarian Hypertension Society and the Dean of the Medical Faculty, Semmelweis University) false true Funding 2045711 /api/funding/2045711 (STIA-OTKA-2021) false true Funding 2045712 /api/funding/2045712 Bolyai+ Kutatói Ösztöndíj(ÚNKP-22-5) Támogató: NKFIH false true true 2024 true true true false true false GOLD 2026-09-07 true https://doi.org/10.3390/ijms252010916 9 0 9 8 1 9 9 8 9 9 9 8 8 8 1 0 9 8 9 8 0 1 1 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 6 5 6 5 2026 0 2 2 2 2 D1 false 10002781,10013908 false false false 2024-11-04T10:49:40.316+0000 Doktori Iskola (SE); Genomikai Medicina és Ritka Betegségek Intézete (SE / AOK / I); Szülészeti és Nőgyógyászati Klinika (SZTE / SZAOK); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Élettani Intézet (SE / AOK / I) 9 26 5 10 0 true 10101397 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 120879071 /api/authorship/120879071 Várhegyi, Vera [Várhegyi, Vera (Klinikai genetika), szerző] Genomikai Medicina és Ritka Betegségek Intézete (SE / AOK / I); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK) 1 0.1 true false false Author 10077740 /api/author/10077740 Várhegyi Vera (Klinikai genetika) Várhegyi Vera true true Várhegyi Vera true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879072 /api/authorship/120879072 Módos, Anna 2 0.1 false false false Módos Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879073 /api/authorship/120879073 Trager, Domonkos [Träger, Domonkos (genetika és neuro...), szerző] Genomikai Medicina és Ritka Betegségek Intézete (SE / AOK / I) 3 0.1 false false false Author 10103126 /api/author/10103126 Träger Domonkos (genetika és neurobiológia) Träger Domonkos true true Trager Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879074 /api/authorship/120879074 Gerszi, Dóra [Gerszi, Dóra (szülészet - nőgyó...), szerző] Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK) 4 0.1 false false false Author 10075334 /api/author/10075334 Gerszi Dóra (szülészet - nőgyógyászat, élettan) Gerszi Dóra true true Gerszi Dóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879075 /api/authorship/120879075 Horváth, Eszter Mária [Horvath, Eszter Mária (Élettan), szerző] Élettani Intézet (SE / AOK / I) 5 0.1 false false false Author 10020503 /api/author/10020503 Horvath Eszter Mária (Élettan) Horvath Eszter Mária true 10020503 true Horváth Eszter Mária true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879076 /api/authorship/120879076 Sipos, Miklós [Sipos, Miklós (asszisztált repro...), szerző] Szülészeti és Nőgyógyászati Klinika Üllői úti r... 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(SE / AOK / K / SZSZNK) 7 0.1 false false false Author 10013998 /api/author/10013998 Ács Nándor (Szülészet-nőgyógyászat) Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879078 /api/authorship/120879078 Molnár, Mária Judit [Molnár, Mária Judit (Neurológia), szerző] Genomikai Medicina és Ritka Betegségek Intézete (SE / AOK / I) 8 0.1 false false false Author 10002781 /api/author/10002781 Molnár Mária Judit (Neurológia) Molnár Mária Judit true 10002781 true Molnár Mária Judit true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879079 /api/authorship/120879079 Várbíró, Szabolcs** [Várbíró, Szabolcs (Keringésélettan), szerző] Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Doktori Iskola (SE); Szülészeti és Nőgyógyászati Klinika (SZTE / SZAOK) 9 0.1 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs (Keringésélettan) Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120879080 /api/authorship/120879080 Gál, Anikó ✉ [Gál, Anikó (Molekuláris bioló...), szerző] Genomikai Medicina és Ritka Betegségek Intézete (SE / AOK / I) 10 0.1 false true true Author 10013908 /api/author/10013908 Gál Anikó (Molekuláris biológia-genetika) Gál Anikó true 10013908 true Gál Anikó true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 27627747 /api/publicationidentifier/27627747 DOI: 10.3390/ijms252010916 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms252010916 https://doi.org/10.3390/ijms252010916 false true PublicationIdentifier 27779565 /api/publicationidentifier/27779565 WoS: 001342659400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001342659400001 https://www.webofscience.com/wos/woscc/full-record/001342659400001 true true PublicationIdentifier 27758649 /api/publicationidentifier/27758649 Scopus: 85207361481 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85207361481 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207361481 true true PublicationIdentifier 27707372 /api/publicationidentifier/27707372 PubMed: 39456699 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39456699 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39456699&dopt=Abstract true true Classification 10631 /api/classification/10631 Genomika true true Classification 12215 /api/classification/12215 Klinikai orvostan true true Classification 12217 /api/classification/12217 Szülészet és nőgyógyászat true true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 58730870 /api/reference/58730870 1. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 20<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077740"><a href="/gui2/?type=authors&mode=browse&sel=10077740" target="_blank">Várhegyi Vera (<span class="authorship-author-name">Várhegyi Vera</span> <span class="authorAux-mtmt"> Klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genomikai Medicina és Ritka Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Módos Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103126"><a href="/gui2/?type=authors&mode=browse&sel=10103126" target="_blank">Trager Domonkos (<span class="authorship-author-name">Träger Domonkos</span> <span class="authorAux-mtmt"> genetika és neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genomikai Medicina és Ritka Betegségek Intézete</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075334"><a href="/gui2/?type=authors&mode=browse&sel=10075334" target="_blank">Gerszi Dóra (<span class="authorship-author-name">Gerszi Dóra</span> <span class="authorAux-mtmt"> szülészet - nőgyógyászat, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020503"><a href="/gui2/?type=authors&mode=browse&sel=10020503" target="_blank">Horváth Eszter Mária (<span class="authorship-author-name">Horvath Eszter Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077450"><a href="/gui2/?type=authors&mode=browse&sel=10077450" target="_blank">Sipos Miklós (<span class="authorship-author-name">Sipos Miklós</span> <span class="authorAux-mtmt"> asszisztált reprodukció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002781"><a href="/gui2/?type=authors&mode=browse&sel=10002781" target="_blank">Molnár Mária Judit (<span class="authorship-author-name">Molnár Mária Judit</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genomikai Medicina és Ritka Betegségek Intézete</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs^** (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013908"><a href="/gui2/?type=authors&mode=browse&sel=10013908" target="_blank">Gál Anikó ✉ (<span class="authorship-author-name">Gál Anikó</span> <span class="authorAux-mtmt"> Molekuláris biológia-genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genomikai Medicina és Ritka Betegségek Intézete</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35452708" target="_blank">GDF-15 and mtDNA Deletions Are Useful Biomarkers of Mitochondrial Dysfunction in Insulin Resistance and PCOS</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">20</span> <span class="page"> Paper 10916. 17 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms252010916" target="_blank" href="https://doi.org/10.3390/ijms252010916"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001342659400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001342659400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85207361481" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85207361481"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39456699" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39456699&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 8 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;9 | DOI jelölt:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35452708&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35452708</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFIH_132812), (TKP2021-NVA-15), (TKP2021-EGA-25), (Hungarian Hypertension Society and the Dean of the Medical Faculty, Semmelweis University), (STIA-OTKA-2021), Bolyai+ Kutatói Ösztöndíj(ÚNKP-22-5) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2026.02.20. 19:26 Balázs András (MTMT Központ, admin) </div> <div class="lockedBy">Központi kezelésű 2026.01.20. 16:16 Tokai Tamás (Központi 2-3, admin) </div> </div></div>