https://m2.mtmt.hu/ eng 2026-05-31 09:16 JournalArticle 35438354 VALIDATED true 0 false 2026-05-30T17:26:50.900+0000 2025-05-16T07:58:33.981+0000 2024-10-07T08:50:14.216+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin true 10035718 5458789 2026-05-07T12:42:43.526+0000 2026-05-07T14:15:47.985+0000 Admin 10035718 /api/admin/10035718 Sonnevend Kinga true 10035718 true DUPLUM 2026-05-07T14:15:47.985+0000 2025-05-16T07:58:34.316+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:49.434+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Than, N.G. Proteomic Profiles of Maternal Plasma Extracellular Vesicles for Prediction of Preeclampsia true true /api/journal/261 REVIEWED true false 261 false 261 true 1046-7408 1600-0897 Journal FOREIGN 92 4 e13928 e13928 19 2024 PROBLEM: Preeclampsia is a heterogeneous syndrome of diverse etiologies and molecular pathways leading to distinct clinical subtypes. Herein, we aimed to characterize the extracellular vesicle (EV)-associated and soluble fractions of the maternal plasma proteome in patients with preeclampsia and to assess their value for disease prediction. METHOD OF STUDY: This case-control study included 24 women with term preeclampsia, 23 women with preterm preeclampsia, and 94 healthy pregnant controls. Blood samples were collected from cases on average 7 weeks before the diagnosis of preeclampsia and were matched to control samples. Soluble and EV fractions were separated from maternal plasma; EVs were confirmed by cryo-EM, NanoSight, and flow cytometry; and 82 proteins were analyzed with bead-based, multiplexed immunoassays. Quantile regression analysis and random forest models were implemented to evaluate protein concentration differences and their predictive accuracy. Preeclampsia subgroups defined by molecular profiles were identified by hierarchical cluster analysis. Significance was set at p < 0.05 or false discovery rate-adjusted q < 0.1. RESULTS: In preterm preeclampsia, PlGF, PTX3, and VEGFR-1 displayed differential abundance in both soluble and EV fractions, whereas angiogenin, CD40L, endoglin, galectin-1, IL-27, CCL19, and TIMP1 were changed only in the soluble fraction (q < 0.1). The direction of changes in the EV fraction was consistent with that in the soluble fraction for nine proteins. In term preeclampsia, CCL3 had increased abundance in both fractions (q < 0.1). The combined EV and soluble fraction proteomic profiles predicted preterm and term preeclampsia with an AUC of 78% (95% CI, 66%-90%) and 68% (95% CI, 56%-80%), respectively. Three clusters of preeclampsia featuring distinct clinical characteristics and placental pathology were identified based on combined protein data. CONCLUSIONS: Our findings reveal distinct alterations of the maternal EV-associated and soluble plasma proteome in preterm and term preeclampsia and identify molecular subgroups of patients with distinct clinical and placental histopathologic features. © 2024 The Author(s). American Journal of Reproductive Immunology published by John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. 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/api/sjrrating/11472550 111 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2723 /api/classificationexternal/2723 true 2723 true Q2 DIRECT true true /api/publication/35438354 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than N.G. (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Baross Street Department </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Romero R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fitzgerald W. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gudicha D.W. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gomez-Lopez N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082656"><a href="/gui2/?type=authors&mode=browse&sel=10082656" target="_blank">Posta M. (<span class="authorship-author-name">Posta Máté</span> <span class="authorAux-mtmt"> Szülészet- és nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_416</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhou F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhatti G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Meyyazhagan A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Awonuga A.O. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chaiworapongsa T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matthies D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bryant D.R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Erez O. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Margolis L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tarca A.L. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35438354" target="_blank">Proteomic Profiles of Maternal Plasma Extracellular Vesicles for Prediction of Preeclampsia</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1046-7408">1046-7408</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1600-0897">1600-0897</a>)</span>: <span class="journal-volume">92</span> <span class="journal-issue">4</span> <span class="page"> Paper e13928. 19 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/aji.13928" target="_blank" href="https://doi.org/10.1111/aji.13928"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001325104400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001325104400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85205335221" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85205335221"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39347565" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39347565&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Obstetrics and Gynecology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Reproductive Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Immunology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 8 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;11 | Number of citations with DOI:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35438354&sort=publishedYear,desc&sort=title"> Number of cited publications: 25 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35438354</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing Duplum | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (LP2014-7/2014,), (HUN-REN SA-83/2021) Funder: HUN_REN, Piacvezérelt kutatás-fejlesztési és innovációs projektek támogatása(2020-1.1.2-PIACI-KFI-2021-00273) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (2019-2.1.7-ERANET-2020-00014) </div> <div class="duplumMark">Duplum marked: 2026.05.07. 14:41 (Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin)) </div> <div class="lastModified">Last Modified: 2025.05.16. 09:58 Éva Pécsi (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> </div></div>