https://m2.mtmt.hu/ hun 2026-09-20 21:08 JournalArticle 35438124 VALIDATED true 0 false 2026-08-12T07:54:23.930+0000 2026-05-08T10:30:00.733+0000 2024-10-07T07:24:27.105+0000 true 10079694 Lázárné Zalán Zita /api/admin/10079694 Admin true 2026-09-16T13:41:06.831+0000 2026-09-16T13:41:06.831+0000 2025-03-08T16:39:15.490+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2025-06-04T11:38:05.975+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mohammed, Aiman Saleh A. Effects of SZV-2649, a new multiple ion channel inhibitor mexiletine analogue true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 14 1 23188 23188 18 2024 The antiarrhythmic and cardiac electrophysiological effects of SZV-2649 that contains a 2,6-diiodophenoxy moiety but lacks the benzofuran ring system present in amiodarone, were studied in mammalian cell line, rat and dog cardiac preparations. SZV-2649 exerted antiarrhythmic effects against coronary artery occlusion/reperfusion induced ventricular arrhythmias in rats and in acetylcholine- and burst stimulation induced atrial fibrillation in dogs. SZV-2649 inhibited hERG and GIRK currents in HEK cells (IC 50 : 342 and 529 nM, respectively). In canine ventricular myocytes, SZV-2649 (10 µM) decreased the densities of I Kr , and I to outward and I NaL and I CaL inward currents. The compound (2.5–10 µM) elicited Class IB type V max reducing and Class III type action potential duration prolonging effects in dog right ventricular muscle preparations. In canine atrial muscle, SZV-2629 (2.5–10 µM) moderately prolonged action potential duration and this effect was greatly augmented in preparations pretreated with 1 µM carbachol. In conclusion, SZV-2649, has antiarrhythmic effects based on its multiple ion channel blocking properties. Since its chemical structure substantially differs from that of amiodarone, it is expected that SZV-2649 would exhibit fewer adverse effects than the currently used most effective multichannel inhibitor drug amiodarone and may be a promising molecule for further development. Funding 2045129 /api/funding/2045129 false true Funding 2045130 /api/funding/2045130 false true Funding 2045131 /api/funding/2045131 false true Funding 2045132 /api/funding/2045132 false true Funding 2045133 /api/funding/2045133 false true Funding 2045134 /api/funding/2045134 false true Funding 2045135 /api/funding/2045135 false true Funding 2045136 /api/funding/2045136 false true Funding 2045137 /api/funding/2045137 false true Funding 2045138 /api/funding/2045138 false true Funding 2045139 /api/funding/2045139 false true Funding 2045140 /api/funding/2045140 false true Funding 2045141 /api/funding/2045141 false true Funding 2045142 /api/funding/2045142 false true Funding 2045143 /api/funding/2045143 false true Funding 2045144 /api/funding/2045144 false true Funding 2045145 /api/funding/2045145 false true true true 2024 true true true false true false GOLD 2026-08-12 true https://real.mtak.hu/206974 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 21 Q1 A nemzetközi false 10001718,10023665,10001232,10022542 false false false 2024-10-06T11:29:48.244+0000 Farmakológiai és Farmakoterápiai Intézet (SZTE / SZAOK); Fertőző Állatbetegségek, Antimikrobiális Rezisz... (ÁTE); Gyógyszerkémiai Intézet (SZTE / GYTK); HUN-REN-SZTE Keringésfarmakológiai Kutatócsoport (SZTE / SZAOK / FFI); HUN-REN-SZTE Sztereokémiai Kutatócsoport (SZTE / GYTK / GYKI); Szerves Vegytani Intézet (SE / GYTK) 17 39 6 17 0 true 10014568 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 120785766 /api/authorship/120785766 1 0.059 true false false Author 10077722 /api/author/10077722 Mohammed Aiman true true Mohammed Aiman Saleh A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120785767 /api/authorship/120785767 2 0.059 true false false Author 10077682 /api/author/10077682 Naveed Muhammad true true Naveed Muhammad true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120785768 /api/authorship/120785768 3 0.059 false false false Author 10067988 /api/author/10067988 Szabados Tamara true true Szabados Tamara true false false AuthorshipType 1 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true 0 true false true PersonAuthorship 120785773 /api/authorship/120785773 8 0.059 false false false Author 10047594 /api/author/10047594 Orvos Péter true 10047594 true Orvos Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120785774 /api/authorship/120785774 9 0.059 false false false Author 10027733 /api/author/10027733 Husti Zoltán true 10027733 true Husti Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120785775 /api/authorship/120785775 10 0.059 false false false Author 10019029 /api/author/10019029 Hornyik Tibor true 10019029 true Hornyik Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120785776 /api/authorship/120785776 11 0.059 false false false Author 10074216 /api/author/10074216 Topal Leila true true Topal Leila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 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/api/reference/58500251 62 10.3390/ijms21196990 false true Reference 58500252 /api/reference/58500252 63 10.1016/j.pharmthera.2013.04.008 false true Reference 58500253 /api/reference/58500253 64 10.1161/CIRCULATIONAHA.105.550111 false true Reference 58500254 /api/reference/58500254 65 10.1371/journal.pone.0053255 false true Reference 58500255 /api/reference/58500255 66 10.1038/sj.bjp.0703777 false true Reference 58500256 /api/reference/58500256 67 10.1016/j.fitote.2014.11.023 false true Reference 58500257 /api/reference/58500257 68 10.1021/acs.jnatprod.8b00500 false true /api/publication/35438124 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077722"><a href="/gui2/?type=authors&mode=browse&sel=10077722" target="_blank">Mohammed Aiman Saleh A. (<span class="authorship-author-name">Mohammed Aiman</span> <span class="authorAux-mtmt"> cardiovascular pharmacology</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077682"><a href="/gui2/?type=authors&mode=browse&sel=10077682" target="_blank">Naveed Muhammad<sup>*</sup> (<span class="authorship-author-name">Naveed Muhammad</span> <span class="authorAux-mtmt"> kísérletes orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067988"><a href="/gui2/?type=authors&mode=browse&sel=10067988" target="_blank">Szabados Tamara (<span class="authorship-author-name">Szabados Tamara</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013053"><a href="/gui2/?type=authors&mode=browse&sel=10013053" target="_blank">Szatmári István (<span class="authorship-author-name">Szatmári István</span> <span class="authorAux-mtmt"> Gyógyszerkutatás, szintetikus szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerkémiai Intézet">GYKI</span>/HUN-REN-SZTE Sztereokémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071650"><a href="/gui2/?type=authors&mode=browse&sel=10071650" target="_blank">Lőrinczi Bálint (<span class="authorship-author-name">Lőrinczi Bálint</span> <span class="authorAux-mtmt"> Gyógyszerkémia, Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007438"><a href="/gui2/?type=authors&mode=browse&sel=10007438" target="_blank">Mátyus Péter (<span class="authorship-author-name">Mátyus Péter</span> <span class="authorAux-mtmt"> Szerves- és gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Szerves Vegytani Intézet; <span title="Állatorvostudományi Egyetem">ÁTE</span>/Fertőző Állatbetegségek, Antimikrobiális Rezisztencia, Állatorvosi Közegészségügyi és Élelmiszerlánc-biztonság Nemzeti Laboratóriuma</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023665"><a href="/gui2/?type=authors&mode=browse&sel=10023665" target="_blank">Czompa Andrea (<span class="authorship-author-name">Czompa Andrea</span> <span class="authorAux-mtmt"> Szerves-és gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Szerves Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047594"><a href="/gui2/?type=authors&mode=browse&sel=10047594" target="_blank">Orvos Péter (<span class="authorship-author-name">Orvos Péter</span> <span class="authorAux-mtmt"> celluláris elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027733"><a href="/gui2/?type=authors&mode=browse&sel=10027733" target="_blank">Husti Zoltán (<span class="authorship-author-name">Husti Zoltán</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019029"><a href="/gui2/?type=authors&mode=browse&sel=10019029" target="_blank">Hornyik Tibor (<span class="authorship-author-name">Hornyik Tibor</span> <span class="authorAux-mtmt"> szívelektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074216"><a href="/gui2/?type=authors&mode=browse&sel=10074216" target="_blank">Topal Leila (<span class="authorship-author-name">Topal Leila</span> <span class="authorAux-mtmt"> farmakológia, elektrofiziológia, kardiol</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054690"><a href="/gui2/?type=authors&mode=browse&sel=10054690" target="_blank">Déri Szilvia (<span class="authorship-author-name">Déri Szilvia</span> <span class="authorAux-mtmt"> szív élet- és kórtana, celluláris elektrofiziol...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Farmakológiai és Farmakoterápiai Intézet">FFI</span>/HUN-REN-SZTE Keringésfarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001072"><a href="/gui2/?type=authors&mode=browse&sel=10001072" target="_blank">Jost Norbert (<span class="authorship-author-name">Jost Norbert László</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Farmakológiai és Farmakoterápiai Intézet">FFI</span>/HUN-REN-SZTE Keringésfarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001637"><a href="/gui2/?type=authors&mode=browse&sel=10001637" target="_blank">Virág László (<span class="authorship-author-name">Virág László</span> <span class="authorAux-mtmt"> Celluláris szívelektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022542"><a href="/gui2/?type=authors&mode=browse&sel=10022542" target="_blank">Bencsik Péter (<span class="authorship-author-name">Bencsik Péter</span> <span class="authorAux-mtmt"> Experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001718"><a href="/gui2/?type=authors&mode=browse&sel=10001718" target="_blank">Baczkó István<sup>**</sup> ✉ (<span class="authorship-author-name">Baczkó István</span> <span class="authorAux-mtmt"> Kardiovaszkuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001232"><a href="/gui2/?type=authors&mode=browse&sel=10001232" target="_blank">Varró András ✉ (<span class="authorship-author-name">Varró András</span> <span class="authorAux-mtmt"> Szívelektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Farmakológiai és Farmakoterápiai Intézet">FFI</span>/HUN-REN-SZTE Keringésfarmakológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35438124" target="_blank">Effects of SZV-2649, a new multiple ion channel inhibitor mexiletine analogue</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">1</span> <span class="page"> Paper 23188. 18 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41598-024-73576-5" target="_blank" href="https://doi.org/10.1038/s41598-024-73576-5"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="206974" target="_blank" href="https://real.mtak.hu/206974"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001330396200055" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001330396200055"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85205965766" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85205965766"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39369049" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39369049&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.nature.com/articles/s41598-024-73576-5" target="_blank" href="https://www.nature.com/articles/s41598-024-73576-5"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="34843" target="_blank" href="http://publicatio.bibl.u-szeged.hu/34843"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35438124&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 21 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35438124</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Intenzív krónikus fizikai tréning indukálta elektrofiziológiai elváltozások a szívműködés automác...(K 135464) Támogató: NKFIH, Új jódtartalmú amiodaronszerű antiaritmiás vegyületek hatásainak vizsgálata(K 142738) Támogató: NKFIH, A pitvari és kamrai szívizomzat kóros átépülésének vizsgálata humán releváns modellekben: új terá...(K 147212) Támogató: NKFIH, (TKP2021-EGA-32) Támogató: NKFIH, Miokardiális remodelling metabolikus szindrómával komplikált poszt-infarktusos szívelégtelenségbe...(OTKA FK-138223) Támogató: NKFI, (GINOP-2.3.2.-15-2016-00006) Támogató: GINOP, GINOP-2.3.2-15-2016-00040(GINOP-2.3.2-15-2016-00040) Támogató: NKFIH, (EFOP-3.6.2–16-2017–00006), (ÚNKP-23-5-SZTE-704), (SZTE AOK-KKA 2021 Dr. Virág László), (SZGYA 2021), (SZTE AOK-KKA 2022 Dr. Jost Norbert), Kooperatív Doktori Program(KDP-2020) Támogató: NKFIH, (BO/481/21), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (RRF-2.3.1-21-2022-00001), (RRF-2.3.1-21-2021) </div> <div class="lastModified">Utolsó módosítás: 2026.05.08. 12:30 Balázs András (MTMT Központ, admin) </div> <div class="lockedBy">Központi kezelésű 2025.06.04. 13:38 Vándor Andrea (VA, admin) Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>