https://m2.mtmt.hu/ hun 2026-10-25 02:07 JournalArticle 35428080 VALIDATED true Department of Radiation Oncology, Foundation Instituto Valenciano de Oncologia (IVO), Valencia, Spain Department of Radiation Oncology, Catalan Institute of Oncology, Barcelona, Spain Radiotherapy Centre, National Institute of Oncology, Budapest, Hungary Department of Oncology, Semmelweis University, Budapest, Hungary Department of Radiation Physics, Foundation Instituto Valenciano de Oncologia (IVO), Valencia, Spain National Institute of Oncology and National Tumor Biology Laboratory, Budapest, Hungary Export Date: 7 October 2024 CODEN: RAOND Correspondence Address: Guinot, J.L.; Department of Radiation Oncology, C/ Profesor Beltrán Baguena 8, Spain; email: jguinot@fivo.org 0 false 2026-05-28T12:58:27.625+0000 2024-11-17T08:17:58.184+0000 2024-10-01T07:05:37.377+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2025-09-01T10:20:43.723+0000 2024-11-17T08:17:58.419+0000 true 10080105 Kériné Tornyi Katalin /api/admin/10080105 Admin true 2025-03-11T09:52:20.683+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080105 /api/admin/10080105 Kériné Tornyi Katalin true true 2024-10-17T16:16:12.275+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Guinot, Jose Luis Five-year results of the very accelerated partial breast irradiation VAPBI phase I-II GEC-ESTRO trial true true /api/journal/3865 REVIEWED true false 3865 false 3865 true 0167-8140 1879-0887 Journal FOREIGN 201 110543 110543 5 2024 The standard partial breast postoperative treatment for early breast carcinomas with multi-catheter interstitial brachytherapy (MIBT) requires 7-8 fractions in 4-5 days as used in the APBI GEC-ESTRO phase III trial. In 2017 the GEC-ESTRO Breast Cancer Working Group started a Phase I-II trial to study if very accelerated partial breast irradiation (VAPBI) using 3-4 fractions could be equivalent.81 patients with low-risk invasive carcinomas underwent high dose rate MIBT. Mean age was 68 (51-90); 33 women received 4 fractions of 6.25 Gy in 2-3 days, and 48 subsequent patients 3 fractions of 7.45 Gy in 2 days, 36 perioperatively and 45 postoperatively.Median follow-up was 62 months, with 5-year actuarial breast recurrence of 3.4 % (two cases). One patient died due to metastasis. Pigmentation changes in the entrance of tubes remained visible only in 12.3 % in long term (skin G1 toxicity). Fibrosis or slight induration (G1) in 22.2 % and G2 in 9.9 %. No case of telangiectasia has been described. Cosmetic outcome is good or excellent in 95 % and fair in 5 %. Four tumors located in the retroareolar area showed nipple retraction.VAPBI with MIBT using four fractions of 6.25 Gy or three fractions of 7.45 Gy in two or three days offers good local control, with a 5-year rate of fibrosis G2 similar to the GEC ESTRO phase III trial. VAPBI in two days is a good choice to decrease the total time of treatment, which is beneficial for the patient and reduces the workload. 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Országos Onkológiai Intézet 3 10 2 9 0 true 10080105 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 120712718 /api/authorship/120712718 1 0.111 true false true Guinot Jose Luis true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712719 /api/authorship/120712719 2 0.11111111 false false false Gutierrez-Miguelez Cristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712720 /api/authorship/120712720 3 0.111 false false false Author 10057309 /api/author/10057309 Mészáros Norbert true 10057309 true Meszaros Norbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712721 /api/authorship/120712721 4 0.11111111 false false false Gonzalez-Perez Victor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712722 /api/authorship/120712722 5 0.11111111 false false false Santos Miguel Angel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712723 /api/authorship/120712723 6 0.11111111 false false false Najjari Dina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712724 /api/authorship/120712724 7 0.11111111 false false false Slocker Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712725 /api/authorship/120712725 8 0.111 false false false Author 10044386 /api/author/10044386 Major Tibor true 10044386 true Major Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120712726 /api/authorship/120712726 9 0.111 false true false Author 10013383 /api/author/10013383 Polgár Csaba true 10013383 true Polgar Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 27566183 /api/publicationidentifier/27566183 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.radonc.2024.110543 https://doi.org/10.1016/j.radonc.2024.110543 false true PublicationIdentifier 27670238 /api/publicationidentifier/27670238 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001329172600001 https://www.webofscience.com/wos/woscc/full-record/001329172600001 true true PublicationIdentifier 27566184 /api/publicationidentifier/27566184 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85204894841 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85204894841 false true PublicationIdentifier 27566182 /api/publicationidentifier/27566182 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39321957 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39321957&dopt=Abstract false true Keyword 1267566 /api/keyword/1267566 true 1267566 true Keyword 1528853 /api/keyword/1528853 true true Keyword 1561981 /api/keyword/1561981 true true Keyword 1657002 /api/keyword/1657002 true true Keyword 1736287 /api/keyword/1736287 true true Keyword 3602773 /api/keyword/3602773 true true Keyword 3602774 /api/keyword/3602774 true true SjrRating 11497490 /api/sjrrating/11497490 21 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2741 /api/classificationexternal/2741 true 2741 true D1 DIRECT true true /api/publication/35428080 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Guinot Jose Luis ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gutierrez-Miguelez Cristina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057309"><a href="/gui2/?type=authors&mode=browse&sel=10057309" target="_blank">Meszaros Norbert (<span class="authorship-author-name">Mészáros Norbert</span> <span class="authorAux-mtmt"> sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gonzalez-Perez Victor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Santos Miguel Angel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Najjari Dina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Slocker Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044386"><a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major Tibor (<span class="authorship-author-name">Major Tibor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgar Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35428080" target="_blank">Five-year results of the very accelerated partial breast irradiation VAPBI phase I-II GEC-ESTRO trial</a></div> <div> <span class="journal-title">RADIOTHERAPY AND ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-8140">0167-8140</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-0887">1879-0887</a>)</span>: <span class="journal-volume">201</span> <span class="page"> Paper 110543. 5 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.radonc.2024.110543" target="_blank" href="https://doi.org/10.1016/j.radonc.2024.110543"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001329172600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001329172600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85204894841" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85204894841"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39321957" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39321957&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hematology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 3 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35428080&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35428080</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (National Tumor Biology Laboratory (2022–2.1.1-NL-2022-00010))), Hungarian Thematic Excellence Program((TKP2021-EGA-44)) </div> <div class="lastModified">Utolsó módosítás: 2024.11.17. 09:17 Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:16 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Radiation Oncology, Foundation Instituto Valenciano de Oncologia (IVO), Valencia, Spain Department of Radiation Oncology, Catalan Institute of Oncology, Barcelona, Spain Radiotherapy Centre, National Institute of Oncology, Budapest, Hungary Department of Oncology, Semmelweis University, Budapest, Hungary ...</pre> </div></div>