https://m2.mtmt.hu/ hun 2026-09-21 06:48 JournalArticle 35427260 VALIDATED true 0 false 2026-08-31T09:01:29.253+0000 2024-12-31T08:32:42.021+0000 2024-09-30T12:48:27.495+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-08-25T12:12:30.487+0000 2024-12-31T08:32:42.028+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:05.205+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dugo, Matteo The Immune-Related 27-Gene Signature DetermaIO Predicts Response to Neoadjuvant Atezolizumab plus Chemotherapy in Triple-Negative Breast Cancer. true true /api/journal/1405637 REVIEWED true false 1405637 false 1405637 true 1078-0432 1557-3265 Journal FOREIGN 30 21 4900 4909 4900 10 2024 We assessed the 27-gene RT-qPCR-based DetermaIO assay and the same score calculated from RNA sequencing (RNA-seq) data as predictors of sensitivity to immune checkpoint therapy in the neoTRIPaPDL1 randomized trial that compared neoadjuvant carboplatin/nab-paclitaxel chemotherapy (CT) plus atezolizumab with CT alone in stage II/III triple-negative breast cancer. We also assessed the predictive function of the immuno-oncology (IO) score in expression data of patients treated with pembrolizumab plus paclitaxel (N = 29) or CT alone (N = 56) in the I-SPY2 trial.RNA-seq data were obtained from pretreatment core biopsies from 242 (93.8%) of the 258 patients in the per-protocol-population. The DetermaIO RT-qPCR test, performed in the CAP/CLIA-accredited laboratory of Oncocyte Corp., was available for 220 patients (85.3%). A previously established threshold was used to assign DetermaIO-positive versus DetermaIO-negative status. Publicly available microarray data were used from I-SPY2.IO scores calculated from RNA-seq and RT-qPCR data were highly concordant. In neoTRIPaPDL1, DetermaIO-positive cancers (N = 92, 41.8%) had pathologic complete response (pCR) rates of 69.8% and 46.9% in the CT + atezolizumab and CT arms, respectively. In DetermaIO-negative cases, pCR rates were similar in both arms (44.6% vs. 49.2%; interaction test P = 0.04). PDL1 protein expression and stromal tumor-infiltrating lymphocyte count were not predictive of differential benefit from atezolizumab. In I-SPY2, IO-positive cancers (45.9%) had pCR rates of 85.7% and 16%, with and without immunotherapy, respectively. In IO-negative cancers, pCR rates were 46.7% versus 16.1%.DetermaIO identified patients who benefited from neoadjuvant immunotherapy resulting in improved pCR rate, independently of PDL1. true true 2024 true true true false true false GOLD 2026-08-31 true https://doi.org/10.1158/1078-0432.CCR-24-0149 24 0 24 21 2 24 24 19 22 24 24 21 21 21 3 0 24 21 24 21 0 1 1 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 13 12 13 12 2026 0 10 8 10 8 D1 false false false false 2024-11-20T08:52:05.928+0000 Biofizikai Intézet (PTE / ÁOK); Bioinformatika Tanszék (SE / AOK / I); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 1 26 3 28 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 120699324 /api/authorship/120699324 1 0.035714287 true false false Dugo Matteo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699325 /api/authorship/120699325 2 0.035714287 false false false Huang Chiun-Sheng true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699326 /api/authorship/120699326 3 0.035714287 false false false Egle Daniel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699327 /api/authorship/120699327 4 0.035714287 false false false Bermejo Begoña true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699328 /api/authorship/120699328 5 0.035714287 false false false Zamagni Claudio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699329 /api/authorship/120699329 6 0.035714287 false false false Seitz Robert S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699330 /api/authorship/120699330 7 0.035714287 false false false Nielsen Tyler J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699331 /api/authorship/120699331 8 0.035714287 false false false Thill Marc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699332 /api/authorship/120699332 9 0.035714287 false false false Antón-Torres Antonio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699333 /api/authorship/120699333 10 0.035714287 false false false Russo Stefania true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699334 /api/authorship/120699334 11 0.035714287 false false false Ciruelos Eva Maria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699335 /api/authorship/120699335 12 0.035714287 false false false Schweitzer Brock L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699336 /api/authorship/120699336 13 0.035714287 false false false Ross Douglas T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699337 /api/authorship/120699337 14 0.035714287 false false false Galbardi Barbara true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699338 /api/authorship/120699338 15 0.035714287 false false false Greil Richard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699339 /api/authorship/120699339 16 0.035714287 false false false Semiglazov Vladimir true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699340 /api/authorship/120699340 17 0.036 false false false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Gyorffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699341 /api/authorship/120699341 18 0.035714287 false false false Colleoni Marco true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699342 /api/authorship/120699342 19 0.035714287 false false false Kelly Catherine M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699343 /api/authorship/120699343 20 0.035714287 false false false Mariani Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699344 /api/authorship/120699344 21 0.035714287 false false false Del Mastro Lucia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699345 /api/authorship/120699345 22 0.035714287 false false false Blasi Olivia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699346 /api/authorship/120699346 23 0.035714287 false false false Callari Maurizio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699347 /api/authorship/120699347 24 0.035714287 false false false Pusztai Lajos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699348 /api/authorship/120699348 25 0.035714287 false false false Valagussa Pinuccia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699349 /api/authorship/120699349 26 0.035714287 false false false Viale Giuseppe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699350 /api/authorship/120699350 27 0.036 false true true Gianni Luca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120699351 /api/authorship/120699351 28 0.036 false true true Bianchini Giampaolo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 27564549 /api/publicationidentifier/27564549 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1158/1078-0432.CCR-24-0149 https://doi.org/10.1158/1078-0432.CCR-24-0149 false true PublicationIdentifier 28125556 /api/publicationidentifier/28125556 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001346370300012 https://www.webofscience.com/wos/woscc/full-record/001346370300012 false true PublicationIdentifier 27986791 /api/publicationidentifier/27986791 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85208270717 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85208270717 false true PublicationIdentifier 27564548 /api/publicationidentifier/27564548 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39308141 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39308141&dopt=Abstract false true Classification 12306 /api/classification/12306 true true SjrRating 11446202 /api/sjrrating/11446202 14 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true D1 DIRECT true true /api/publication/35427260 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Dugo Matteo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Huang Chiun-Sheng </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Egle Daniel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bermejo Begoña </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zamagni Claudio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seitz Robert S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nielsen Tyler J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thill Marc </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Antón-Torres Antonio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Russo Stefania </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciruelos Eva Maria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schweitzer Brock L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ross Douglas T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galbardi Barbara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Greil Richard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Semiglazov Vladimir </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Gyorffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület); <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Colleoni Marco </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kelly Catherine M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mariani Gabriella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Del Mastro Lucia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Blasi Olivia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Callari Maurizio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pusztai Lajos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Valagussa Pinuccia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Viale Giuseppe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gianni Luca<sup>**</sup> ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianchini Giampaolo ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35427260" target="_blank">The Immune-Related 27-Gene Signature DetermaIO Predicts Response to Neoadjuvant Atezolizumab plus Chemotherapy in Triple-Negative Breast Cancer.</a></div> <div> <span class="journal-title">CLINICAL CANCER RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1078-0432">1078-0432</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-3265">1557-3265</a>)</span>: <span class="journal-volume">30</span> <span class="journal-issue">21</span> <span class="page"> pp 4900-4909 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1158/1078-0432.CCR-24-0149" target="_blank" href="https://doi.org/10.1158/1078-0432.CCR-24-0149"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001346370300012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001346370300012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85208270717" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85208270717"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39308141" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39308141&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 24</span> | Független: 21 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 19 | Scopus jelölt:&nbsp;22 | WoS/Scopus jelölt:&nbsp;24 | DOI jelölt:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35427260&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35427260</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.12.31. 09:32 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:27 Vándor Andrea (VA, admin) </div> </div></div>