https://m2.mtmt.hu/ hun 2026-10-24 08:00 JournalArticle 35425688 VALIDATED true 0 false 2026-09-27T18:27:32.531+0000 2026-08-28T14:08:29.301+0000 2024-09-30T06:07:55.405+0000 true 10082843 Berhidi Anna /api/admin/10082843 Admin true 2026-08-28T14:08:29.521+0000 2026-08-28T14:08:29.521+0000 2024-10-18T09:25:10.708+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Jakab, Ákos Local Invasion Patterns Characterized by SARIFA and Tumor Budding Differ and Have Distinct Prognostic Significance in Esophageal Adenocarcinoma and Squamous Cell Carcinoma true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 16 18 3144 3144 16 2024 Both esophageal squamous cell carcinoma (ESQCC) and adenocarcinoma (EAC) are known to have poor prognosis. We aimed to investigate the invasion front areas of 57 ESQCC and 43 EAC cases to find histological signs of metastatic progression. Tumor cell clusters with different cell counts, including tumor buds (TBs) and poorly differentiated clusters (PDCs), were assessed. The presence of the recently described Stroma AReactive Invasion Front Area (SARIFA) phenomenon, which defines a direct contact between tumor cells and adipocytes, was more frequently observed in EAC than in ESQCC (p = 0.004). In adenocarcinomas, a higher prevalence of SARIFA was observed in tumors with a higher number of small clusters (TBs and small PDCs; p < 0.001); furthermore, both the high number of TBs (p = 0.016) and the presence of SARIFA (p = 0.001) correlated with a higher pT stage. SARIFA positivity in EAC (p = 0.011) and high TB in ESQCC (p = 0.0006) were found to be independent prognostic factors for lymph node metastases. Moreover, in ESQCC, the higher absolute number of both TBs and PDCs was associated with shorter overall survival (p = 0.0269 and p = 0.0377, respectively). Our results suggest that the histological subtypes of esophageal cancer behave differently, namely, that different features of the invasion front are of prognostic significance. Funding 2044767 /api/funding/2044767 false true Funding 2044768 /api/funding/2044768 false true Funding 2044769 /api/funding/2044769 false true true true NATIONAL 2024 true true true false true false GOLD 2026-09-27 true https://doi.org/10.3390/cancers16183144 7 0 7 7 1 7 7 7 7 7 7 7 7 7 0 0 7 7 7 7 0 2 2 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 4 4 4 4 Q1 false 10016981 false false false 2024-10-07T06:09:44.041+0000 Országos Onkológiai Intézet; Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39335115&dopt=Abstract false true Classification 12306 /api/classification/12306 true true Keyword 1003539 /api/keyword/1003539 true 1003539 true Keyword 1117967 /api/keyword/1117967 true 1117967 true Keyword 1513449 /api/keyword/1513449 true true Keyword 1664805 /api/keyword/1664805 true true Keyword 1977060 /api/keyword/1977060 true true Keyword 2037193 /api/keyword/2037193 true true Keyword 3602594 /api/keyword/3602594 true true SjrRating 11488787 /api/sjrrating/11488787 86 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/35425688 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10088121"><a href="/gui2/?type=authors&mode=browse&sel=10088121" target="_blank">Jakab Ákos (<span class="authorship-author-name">Jakab Ákos</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zarándy Levente </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061659"><a href="/gui2/?type=authors&mode=browse&sel=10061659" target="_blank">Kocsmár Ildikó (<span class="authorship-author-name">Kocsmár Ildikó</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027229"><a href="/gui2/?type=authors&mode=browse&sel=10027229" target="_blank">Várkonyi Tibor (<span class="authorship-author-name">Várkonyi Tibor</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017547"><a href="/gui2/?type=authors&mode=browse&sel=10017547" target="_blank">Kenessey István (<span class="authorship-author-name">Kenessey István</span> <span class="authorAux-mtmt"> Patológia, onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet; Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001995"><a href="/gui2/?type=authors&mode=browse&sel=10001995" target="_blank">Szijártó Attila (<span class="authorship-author-name">Szijártó Attila</span> <span class="authorAux-mtmt"> Sebészet, kísérletes sebészet, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss András (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031538"><a href="/gui2/?type=authors&mode=browse&sel=10031538" target="_blank">Vass Tamás (<span class="authorship-author-name">Vass Tamás</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016981"><a href="/gui2/?type=authors&mode=browse&sel=10016981" target="_blank">Lotz Gábor<sup>**</sup> ✉ (<span class="authorship-author-name">Lotz Gábor</span> <span class="authorAux-mtmt"> Hepatológia, pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061496"><a href="/gui2/?type=authors&mode=browse&sel=10061496" target="_blank">Kocsmár Éva ✉ (<span class="authorship-author-name">Kocsmár Éva</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35425688" target="_blank">Local Invasion Patterns Characterized by SARIFA and Tumor Budding Differ and Have Distinct Prognostic Significance in Esophageal Adenocarcinoma and Squamous Cell Carcinoma</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">18</span> <span class="page"> Paper 3144. 16 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cancers16183144" target="_blank" href="https://doi.org/10.3390/cancers16183144"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001326416300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001326416300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85205265094" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85205265094"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39335115" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39335115&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 7 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35425688&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35425688</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (K_22 142604) Támogató: OTKA, New National Excellence Program(ÚNKP-23-4-II-SE-24), Egyetemi Kutatói Ösztöndíj Program(EKÖP-2024-72) Támogató: Kulturális és Innovációs Minisztérium Nemzeti Kutatási Fejlesztési és Innovációs Alap </div> <div class="lastModified">Utolsó módosítás: 2026.08.28. 16:08 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>