https://m2.mtmt.hu/ eng 2026-06-27 18:45 JournalArticle 35425085 VALIDATED true 0 false 2026-06-11T14:05:24.519+0000 2025-03-05T10:41:34.260+0000 2024-09-29T04:43:04.487+0000 true 10038807 Spisák Sándor /api/author/10038807 Author Sándor Spisák (Molekuláris genetika) true 10038807 2026-03-02T13:40:36.704+0000 2025-03-13T21:07:13.877+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true Admin 10067876 /api/admin/10067876 Gusztáv Ladányi (MTMT API user, admin) Ladányi Gusztáv true true 2024-12-02T10:30:26.681+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType Study Group (Journal Article) 104 true 10000359 true 1 /api/category/1 Category Scientific true 1 Diossy, Miklos true true /api/journal/10082889 REVIEWED NPJ PRECISION ONCOLOGY 2397-768X true false 10082889 false 10082889 true 2397-768X Journal FOREIGN 8 1 208 208 13 2024 We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1 (CHD1) loss on prostate cancer tissue microarrays. We created CHD1-deficient prostate cancer cell lines for genomic, drug sensitivity and functional homologous recombination (HR) activity analysis. Subclonal deletion of CHD1 was nearly three times as frequent in prostate tumors of African American than in European American men and it associates with rapid disease progression. CHD1 deletion was not associated with HR deficiency associated mutational signatures or HR deficiency as detected by RAD51 foci formation. This was consistent with the moderate increase of olaparib and talazoparib sensitivity with several CHD1 deficient cell lines showing talazoparib sensitivity in the clinically relevant concentration range. CHD1 loss may contribute to worse disease outcome in African American men. Funding 2044804 /api/funding/2044804 (KTIA_NAP_13-2014-0021) false true Funding 2044805 /api/funding/2044805 (NAP2-2017-1.2.1-NKP-0002) false true true 2024 true true true false false GOLD 2026-06-11 true https://doi.org/10.1038/s41698-024-00705-8 5 0 5 4 0 5 5 5 5 5 5 4 4 4 1 0 5 4 5 4 0 8 8 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 3 4 3 2026 0 1 1 1 1 D1 false 10038807 false false false 2024-09-29T07:47:21.409+0000 Bioinformatika Tanszék (SE / AOK / I); II. Sz. Patológiai Intézet (SE / AOK / I); Komplex Rendszerek Fizikája Tanszék (ELTE / TTK / FizCsill_I); MTA-SE Molekuláris Medicina Kutatócsoport (SE / AOK / K / BOK); Molekuláris Élettudományi Intézet (HRN TTK) 6 36 5 35 0 true 10067876 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 120679544 /api/authorship/120679544 Diossy, Miklos 1 0.0 true false false Diossy Miklos true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679545 /api/authorship/120679545 Tisza, Viktoria* [Tisza, Viktoria (molekularis biologia), author] 2 0.0 true false false Author 10082012 /api/author/10082012 Viktoria Tisza (molekularis biologia) Tisza Viktoria true true Tisza Viktoria true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679546 /api/authorship/120679546 Li, Hua* 3 0.0 true false false Li Hua true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679547 /api/authorship/120679547 Sahgal, Pranshu 4 0.0 false false false Sahgal Pranshu true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679548 /api/authorship/120679548 Zhou, Jia 5 0.0 false false false Zhou Jia true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679549 /api/authorship/120679549 Sztupinszki, Zsofia 6 0.0 false false false Sztupinszki Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679550 /api/authorship/120679550 Young, Denise 7 0.0 false false false Young Denise true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679551 /api/authorship/120679551 Nousome, Darryl 8 0.0 false false false Nousome Darryl true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679552 /api/authorship/120679552 Kuo, Claire 9 0.0 false false false Kuo Claire true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679553 /api/authorship/120679553 Jiang, Jiji 10 0.0 false false false Jiang Jiji true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679554 /api/authorship/120679554 Chen, Yongmei 11 0.0 false false false Chen Yongmei true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679555 /api/authorship/120679555 Ebner, Reinhard 12 0.0 false false false Ebner Reinhard true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679556 /api/authorship/120679556 Sesterhenn, Isabell A. 13 0.0 false false false Sesterhenn Isabell A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679557 /api/authorship/120679557 Moncur, Joel T. 14 0.0 false false false Moncur Joel T. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679558 /api/authorship/120679558 Chesnut, Gregory T. 15 0.0 false false false Chesnut Gregory T. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679559 /api/authorship/120679559 Petrovics, Gyorgy 16 0.0 false false false Petrovics Gyorgy true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679560 /api/authorship/120679560 Klus, Gregory T. 17 0.0 false false false Klus Gregory T. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679561 /api/authorship/120679561 Valcz, Gabor [Valcz, Gábor (gasztroenterológia), author] MTA-SE Molecular Medicine Research Unit (SU / FM / C / DIMO) 18 0.0 false false false Author 10027279 /api/author/10027279 Gábor Valcz (gasztroenterológia) Valcz Gábor true 10027279 true Valcz Gabor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679562 /api/authorship/120679562 Nuzzo, Pier Vitale 19 0.0 false false false Nuzzo Pier Vitale true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679563 /api/authorship/120679563 Ribli, Dezso 20 0.0 false false false Ribli Dezso true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679564 /api/authorship/120679564 Börcsök, Judit 21 0.0 false false false Börcsök Judit true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679565 /api/authorship/120679565 Prosz, Aurel 22 0.0 false false false Prosz Aurel true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679566 /api/authorship/120679566 Krzystanek, Marcin 23 0.0 false false false Krzystanek Marcin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679567 /api/authorship/120679567 Ried, Thomas 24 0.0 false false false Ried Thomas true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679568 /api/authorship/120679568 Szuts, David [Szüts, Dávid (Molekuláris biológia), author] Institute of Molecular Life Sciences 25 0.0 false false false Author 10026660 /api/author/10026660 Dávid Szüts (Molekuláris biológia) Szüts Dávid true 10026660 true Szuts David true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679569 /api/authorship/120679569 Rizwan, Kinza 26 0.0 false false false Rizwan Kinza true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679570 /api/authorship/120679570 Kaochar, Salma 27 0.0 false false false Kaochar Salma true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679571 /api/authorship/120679571 Pathania, Shailja 28 0.0 false false false Pathania Shailja true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679572 /api/authorship/120679572 D’Andrea, Alan D. 29 0.0 false false false D’Andrea Alan D. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679573 /api/authorship/120679573 Csabai, Istvan [Csabai, István (Statisztikus fizika), author] Department of Physics of Complex Systems (ELTE / ELU FoS) 30 0.0 false false false Author 10000521 /api/author/10000521 István Csabai (Statisztikus fizika) Csabai István true 10000521 true Csabai Istvan true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679574 /api/authorship/120679574 Srivastava, Shiv 31 0.0 false false false Srivastava Shiv true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679575 /api/authorship/120679575 Freedman, Matthew L. ✉ 32 0.0 false false true Freedman Matthew L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679576 /api/authorship/120679576 Dobi, Albert ✉ 33 0.0 false false true Dobi Albert true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679577 /api/authorship/120679577 Spisak, Sandor ✉ [Spisák, Sándor (Molekuláris genetika), author] Institute of Molecular Life Sciences 34 0.0 false false true Author 10038807 /api/author/10038807 Sándor Spisák (Molekuláris genetika) Spisák Sándor true 10038807 true Spisak Sandor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 120679578 /api/authorship/120679578 Szallasi, Zoltan ✉ [Szállási, Zoltán (Onkológia, dagana...), author] Bioinformatika Tanszék (SU / FM / I); II. Department of Pathology (SU / FM / I) 35 0.0 false true true Author 10068108 /api/author/10068108 Zoltán Szállási (Onkológia, daganatkutatás) Szállási Zoltán true true Szallasi Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 27559435 /api/publicationidentifier/27559435 DOI: 10.1038/s41698-024-00705-8 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41698-024-00705-8 https://doi.org/10.1038/s41698-024-00705-8 false true PublicationIdentifier 27559437 /api/publicationidentifier/27559437 WoS: 001315758200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001315758200001 https://www.webofscience.com/wos/woscc/full-record/001315758200001 false true PublicationIdentifier 27560465 /api/publicationidentifier/27560465 REAL: 206471 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 206471 https://real.mtak.hu/206471 false true PublicationIdentifier 27561097 /api/publicationidentifier/27561097 Scopus: 85204375492 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85204375492 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85204375492 true true PublicationIdentifier 27561099 /api/publicationidentifier/27561099 PubMed: 39294262 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39294262 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39294262&dopt=Abstract true true Classification 12215 /api/classification/12215 Clinical medicine true true SjrRating 11488729 /api/sjrrating/11488729 sjr:D1 (2024) Scopus - Oncology NPJ PRECISION ONCOLOGY 2397-768X 32 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 Scopus - Oncology true 2730 true D1 DIRECT true true Reference 58252818 /api/reference/58252818 1. 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(2024) NPJ PRECISION ONCOLOGY 2397-768X 8 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Diossy Miklos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082012"><a href="/gui2/?type=authors&mode=browse&sel=10082012" target="_blank">Tisza Viktoria^* (<span class="authorship-author-name">Tisza Viktoria</span> <span class="authorAux-mtmt"> molekularis biologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027279"><a href="/gui2/?type=authors&mode=browse&sel=10027279" target="_blank">Valcz Gabor (<span class="authorship-author-name">Valcz Gábor</span> <span class="authorAux-mtmt"> gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/MTA-SE Molecular Medicine Research Unit</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026660"><a href="/gui2/?type=authors&mode=browse&sel=10026660" target="_blank">Szuts David (<span class="authorship-author-name">Szüts Dávid</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000521"><a href="/gui2/?type=authors&mode=browse&sel=10000521" target="_blank">Csabai Istvan (<span class="authorship-author-name">Csabai István</span> <span class="authorAux-mtmt"> Statisztikus fizika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics and Astronomy">InstPhysicsAstro</span>/Department of Physics of Complex Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038807"><a href="/gui2/?type=authors&mode=browse&sel=10038807" target="_blank">Spisak Sandor ✉ (<span class="authorship-author-name">Spisák Sándor</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068108"><a href="/gui2/?type=authors&mode=browse&sel=10068108" target="_blank">Szallasi Zoltan ✉ (<span class="authorship-author-name">Szállási Zoltán</span> <span class="authorAux-mtmt"> Onkológia, daganatkutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology</span> et al. (35) </div> <div><a target="_blank" href="/api/publication/35425085?labelLang=eng">All authors</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35425085" target="_blank">Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression</a></div> <div> <span class="journal-title">NPJ PRECISION ONCOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2397-768X">2397-768X</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper 208. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41698-024-00705-8" target="_blank" href="https://doi.org/10.1038/s41698-024-00705-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001315758200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001315758200001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="206471" target="_blank" href="https://real.mtak.hu/206471"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85204375492" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85204375492"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39294262" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39294262&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 4 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35425085&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35425085</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Study Group ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (KTIA_NAP_13-2014-0021), (NAP2-2017-1.2.1-NKP-0002) </div> <div class="lastModified">Last Modified: 2025.03.05. 11:41 Viktoria Tisza (molekularis biologia) </div> <div class="lockedBy">Centrally managed 2024.12.02. 11:30 Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>