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            Correspondence Address: Kukor, Z.; Institute of Biochemistry and Molecular Biology, Hungary; email: kukor.zoltan@semmelweis.hu</comment>
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      <abstractText>Background: Preeclampsia is a leading cause of pregnancy-related maternal and fetal morbidity and mortality. Although its precise cause and prevention remain unclear, risk factors such as overweight and inadequate nutrient intake (e.g., calcium, folic acid, and vitamin D) are known to increase its incidence. Recent research has focused on the genetic predisposition to preeclampsia, identifying polymorphisms that may affect enzyme or receptor function. This study aims to review existing literature examining the relationship between genetic polymorphisms, BMI (body mass index), and nutrient levels in preeclampsia to develop more actionable therapeutic strategies. Methods: A systematic review was conducted to analyze studies on the nutrigenetic relationship between BMI, micronutrients, and preeclampsia. Results: A total of 17 studies investigating 12 genes related to BMI and 10 studies exploring 3 genes in relation to micronutrient levels were included in the analysis. Several polymorphisms associated with preeclampsia were found to be influenced by maternal BMI or serum vitamin levels. The interactions between certain gene variants and these factors suggest that both BMI and micronutrient status may modify the risk of developing preeclampsia in genetically predisposed individuals. Conclusions: Our findings emphasize the potential for reanalyzing existing data by categorizing based on genotype and nutrient levels. This approach could yield more personalized dietary and therapeutic recommendations for managing preeclampsia. In the future, genetic information may support the development of tailored nutritional counseling during pregnancy to mitigate preeclampsia risk.</abstractText>
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          <label>93. Kukor 2000: Regulation of nitric oxide synthase activity by tetrahydrobiopterin in human placentae from normal and pre-eclamptic pregnancies., Placenta, 21, p. 763, DOI: 10.1053/plac.2000.0584</label>
          <listPosition>93</listPosition>
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          <label>94. Kukor 1996: Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta., Placenta, 17, p. 69, DOI: 10.1016/S0143-4004(05)80645-9</label>
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          <label>95. Kukor 1997: Tetrahydrobiopterin preferentially stimulates activity and promotes subunit aggregation of membrane-bound calcium-dependent nitric oxide synthase in human placenta., Mol. Hum. Reprod., 3, p. 293, DOI: 10.1093/molehr/3.4.293</label>
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          <doi>10.1093/molehr/3.4.293</doi>
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          <label>96. Kukor 2020: A pravasztatin hatása tetrahidrobiopterin-érzékeny és -rezisztens praeeclampsiás placenták NO-szintáz-aktivitására [Effect of pravastatin on tetrahydrobiopterin-sensitive and -resistant NO synthase activity of preeclamptic placentas]., Orv. Hetil., 161, p. 389, DOI: 10.1556/650.2020.31670</label>
          <listPosition>96</listPosition>
          <doi>10.1556/650.2020.31670</doi>
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          <mtid>58129973</mtid>
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          <label>97. Pánczél, Z., Kukor, Z., Supák, D., Kovács, B., Kecskeméti, A., Czizel, R., Djurecz, M., Alasztics, B., Csomó, K.B., and Hrabák, A. (2019). Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas. BMC Pregnancy Childbirth, 19., DOI: 10.1186/s12884-019-2507-0</label>
          <listPosition>97</listPosition>
          <doi>10.1186/s12884-019-2507-0</doi>
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        <reference>
          <otype>Reference</otype>
          <mtid>58129974</mtid>
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          <label>98. Stehle 2004: What are the essential elements needed for the determination of amino acid requirements in humans?., J. Nutr., 134, p. 1558S, DOI: 10.1093/jn/134.6.1558S</label>
          <listPosition>98</listPosition>
          <doi>10.1093/jn/134.6.1558S</doi>
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          <otype>Reference</otype>
          <mtid>58129975</mtid>
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          <label>99. Calder 1999: Glutamine and the immune system., Amino Acids, 17, p. 227, DOI: 10.1007/BF01366922</label>
          <listPosition>99</listPosition>
          <doi>10.1007/BF01366922</doi>
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          <otype>Reference</otype>
          <mtid>58129976</mtid>
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          <label>100. Wu 1998: Intestinal mucosal amino acid catabolism., J. Nutr., 128, p. 1249, DOI: 10.1093/jn/128.8.1249</label>
          <listPosition>100</listPosition>
          <doi>10.1093/jn/128.8.1249</doi>
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          <label>101. Prameswari, N., Irwinda, R., Wibowo, N., and Saroyo, Y.B. (2022). Maternal Amino Acid Status in Severe Preeclampsia: A Cross-Sectional Study. Nutrients, 14., DOI: 10.3390/nu14051019</label>
          <listPosition>101</listPosition>
          <doi>10.3390/nu14051019</doi>
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2024.10.21. 11:20 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 9 February 2025            
            Correspondence Address: Kukor, Z.; Institute of Biochemistry and Molecular Biology, Hungary; email: kukor.zoltan@semmelweis.hu&lt;/pre&gt;
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