Background.In the United States, universal screening for human T-lymphotropic virus
(HTLV) in deceased organ donors was discontinued in 2009. Since then, the transplant
guideline suggests considering targeted screening. However, the outcomes of this change
in HTLV screening have not been evaluated. Methods.Using the Organ Procurement and
Transplantation Network database between 2010 and 2022, we analyzed the HTLV antibody
screening frequency and seroprevalence in potential deceased organ donors and their
correlations with HTLV infection risks, including race and high-risk behaviors for
blood-borne pathogen infection. Although targeted screening has not been established
for HTLV, we hypothesized that screening rates should correlate with the proportions
of donors with infection risk if screening is targeted. We also evaluated the organ
utilization of HTLV-seropositive donors. Results.Of 130 284 potential organ donors,
22 032 (16.9%) were tested for HTLV antibody. The proportion of donors tested for
HTLV varied between Organ Procurement Organizations (median [interquartile range],
3.8% [1.0%-23.2%]; range, 0.2%-99.4%) and was not correlated to HTLV infection risks.
There were 48 seropositive donors (0.22%), and at least 1 organ from 42 of these donors
(87.5%) was transplanted. The number of organs recovered and transplanted per donor
was significantly lower in HTLV-seropositive than in HTLV-negative donors (recovered,
2 [2-3] versus 3 [3-5], P < 0.001; transplanted, 2 [1-3] versus 3 [2-4], P < 0.001).
However, HTLV-1 infection was not attributed as the cause of nonrecovery except for
only 1 HTLV-seropositive donor. Conclusions.HTLV screening practices varied across
the United States. Our findings suggest that targeted screening was not performed
after the elimination of universal screening.
