https://m2.mtmt.hu/ hun 2026-05-04 10:37 JournalArticle 35417664 VALIDATED true Export Date: 24 November 2024 0 false 2026-04-30T06:56:24.480+0000 2024-10-21T09:49:17.613+0000 2024-09-24T20:06:11.546+0000 true 10000786 Csala Miklós /api/author/10000786 Author Csala Miklós (Biokémia) true 10000786 2025-03-12T00:33:24.335+0000 2024-10-21T09:49:17.788+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Gurbi, Bianka true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 19 10274 10274 15 2024 Head and neck squamous cell carcinomas (HNSCC) are among the most common malignancies in men worldwide. Nevertheless, their clinical management is hampered by the limited availability of reliable predictive and prognostic biomarkers. Protein kinase D (PKD) isoforms contribute to major cellular processes. However, their potential role in HNSCC has not been studied systematically, which is the focus of this study. A total of 63 therapy-naive patients with squamous cell carcinoma were consecutively enrolled. Tissue microarray duplicate cores from each case were tested in situ for PKD1, PKD2, and PKD3 expression using immunohistochemistry, and the results were correlated with clinicopathological parameters. We found a high frequency of PKD1/PKD2 positive cases in oropharyngeal and PKD2 positive cases in laryngeal localizations. Only high PKD2 levels were statistically linked to elevated tumor grades, more advanced TNM (3–4) tumor stages, and p16INK4a expression, while elevated PKD3 levels were associated with favorable disease-specific survival. Both PKD2 and PKD3 have been proposed to promote tumor cell proliferation, migration/invasion, and angiogenesis. However, the role of PKD3 was elusive in some cancers. Our findings suggest that testing for PKD isotypes with immunohistochemistry may support the diagnostic estimation of tumor progression and prognosis in HNSCC with a potential therapeutic relevance. Funding 2045272 /api/funding/2045272 Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma false true true true 2024 true true true false true false GOLD 2026-04-30 false http://www.mdpi.com/journal/ijms 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 D1 false 10038518,10059086,10000786 false false false 2024-10-08T12:51:33.280+0000 Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika (SE / AOK / K); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 8 26 3 8 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 120587022 /api/authorship/120587022 Gurbi, Bianka [Gurbi, Bianka (célzott daganatte...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.125 true false false Author 10059086 /api/author/10059086 Gurbi Bianka (célzott daganatterápia) Gurbi Bianka true 10059086 true Gurbi Bianka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587023 /api/authorship/120587023 Dános, Kornél [Dános, Kornél (Fül-Orr-Gégészet;...), szerző] Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika (SE / AOK / K) 2 0.125 false false false Author 10038518 /api/author/10038518 Dános Kornél (Fül-Orr-Gégészet; Fej-Nyaksebészet, Onkológia) Dános Kornél true 10038518 true Dános Kornél true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587024 /api/authorship/120587024 Birtalan, Ede [Birtalan, Ede (fül-orr-gégészet,...), szerző] Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika (SE / AOK / K) 3 0.125 false false false Author 10046517 /api/author/10046517 Birtalan Ede (fül-orr-gégészet, fej-nyak sebészet) Birtalan Ede true 10046517 true Birtalan Ede true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587025 /api/authorship/120587025 Krenács, Tibor [Krenács, Tibor (Sejtbiológia, imm...), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 4 0.125 false false false Author 10007878 /api/author/10007878 Krenács Tibor (Sejtbiológia, immunológia, pathológia) Krenács Tibor true 10007878 true Krenács Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587026 /api/authorship/120587026 Kovács, Borbála [Kovács, Borbála (Biológiai hálózatok), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 5 0.125 false false false Author 10072470 /api/author/10072470 Kovács Borbála (Biológiai hálózatok) Kovács Borbála true true Kovács Borbála true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587027 /api/authorship/120587027 Tamás, László [Tamás, László (Fül-orr-gégészet), szerző] Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika (SE / AOK / K) 6 0.125 false false false Author 10010129 /api/author/10010129 Tamás László (Fül-orr-gégészet) Tamás László true 10010129 true Tamás László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587028 /api/authorship/120587028 Csala, Miklós ✉ [Csala, Miklós (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 7 0.125 false false true Author 10000786 /api/author/10000786 Csala Miklós (Biokémia) Csala Miklós true 10000786 true Csala Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 120587029 /api/authorship/120587029 Varga, Attila [Varga, Attila (molekuláris biológia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 8 0.125 false true false Author 10040840 /api/author/10040840 Varga Attila (molekuláris biológia) Varga Attila true 10040840 true Varga Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 27537738 /api/publicationidentifier/27537738 DOI: 10.3390/ijms251910274 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms251910274 https://doi.org/10.3390/ijms251910274 false true PublicationIdentifier 27672114 /api/publicationidentifier/27672114 WoS: 001332343900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001332343900001 https://www.webofscience.com/wos/woscc/full-record/001332343900001 true true PublicationIdentifier 27672124 /api/publicationidentifier/27672124 Scopus: 85206299567 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85206299567 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85206299567 true true PublicationIdentifier 27672123 /api/publicationidentifier/27672123 PubMed: 39408603 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39408603 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39408603&dopt=Abstract true true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 57976725 /api/reference/57976725 1. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 19<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10059086"><a href="/gui2/?type=authors&mode=browse&sel=10059086" target="_blank">Gurbi Bianka (<span class="authorship-author-name">Gurbi Bianka</span> <span class="authorAux-mtmt"> célzott daganatterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038518"><a href="/gui2/?type=authors&mode=browse&sel=10038518" target="_blank">Dános Kornél (<span class="authorship-author-name">Dános Kornél</span> <span class="authorAux-mtmt"> Fül-Orr-Gégészet; Fej-Nyaksebészet, Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046517"><a href="/gui2/?type=authors&mode=browse&sel=10046517" target="_blank">Birtalan Ede (<span class="authorship-author-name">Birtalan Ede</span> <span class="authorAux-mtmt"> fül-orr-gégészet, fej-nyak sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007878"><a href="/gui2/?type=authors&mode=browse&sel=10007878" target="_blank">Krenács Tibor (<span class="authorship-author-name">Krenács Tibor</span> <span class="authorAux-mtmt"> Sejtbiológia, immunológia, pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072470"><a href="/gui2/?type=authors&mode=browse&sel=10072470" target="_blank">Kovács Borbála (<span class="authorship-author-name">Kovács Borbála</span> <span class="authorAux-mtmt"> Biológiai hálózatok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010129"><a href="/gui2/?type=authors&mode=browse&sel=10010129" target="_blank">Tamás László (<span class="authorship-author-name">Tamás László</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000786"><a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala Miklós ✉ (<span class="authorship-author-name">Csala Miklós</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040840"><a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga Attila (<span class="authorship-author-name">Varga Attila</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35417664" target="_blank">Potential Prognostic Role of Protein Kinase D Isoforms in Head and Neck Cancers</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">19</span> <span class="page"> Paper 10274. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms251910274" target="_blank" href="https://doi.org/10.3390/ijms251910274"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001332343900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001332343900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85206299567" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85206299567"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39408603" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39408603&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35417664&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35417664</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma </div> <div class="lastModified">Utolsó módosítás: 2024.10.21. 11:49 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 24 November 2024</pre> </div></div>