https://m2.mtmt.hu/ eng 2026-07-27 00:50 BookChapter 35244976 VALIDATED true 0 false 2025-12-03T13:01:33.313+0000 2024-09-11T07:42:26.886+0000 2024-09-10T07:28:29.870+0000 true 10088377 Marótiné Pántos Szilvia /api/admin/10088377 Admin Szilvia Marótiné Pántos (SZTE admin5 TTIK Bolyai Intézet) true 2024-11-04T12:54:57.303+0000 2024-11-04T12:54:57.303+0000 2024-09-11T07:42:26.893+0000 true 10058176 Nagyné Tari Emese /api/admin/10058176 Admin Emese Nagyné Tari (SZTE admin5) true 10058176 Admin 10003132 /api/admin/10003132 András Balázs (MTMT Központ, admin) Balázs András true 10003132 true 2025-10-21T08:41:48.035+0000 true false true 25 25 /api/publicationtype/25 PublicationType Chapter in Book 2 true 25 BookChapter true 10000303 Study true 25 25 /api/publicationtype/25 PublicationType Chapter in Book 2 true 25 BookChapter /api/subtype/10000303 Szaktanulmány SubType Study (Chapter in Book) 219 true 10000303 true 1 /api/category/1 Category Scientific true 1 Röst, Gergely 217 232 217 16 2024 Vaccination has proven to be the most effective public health measure in the fight against various infectious diseases. For emerging or re-emerging diseases, a highly efficacious vaccine may not be available at the start of an outbreak. Timelines for availability of a safe and effective vaccine may significantly affect disease dynamics, its burden, and the healthcare resource utilization. Mitigating this impact may then rely on low-efficacy vaccines that may be rapidly produced and distributed to at-risk populations at the early stages of an outbreak. With the expectation for arrival of a more effective vaccine at a later stage of the outbreak, the optimal vaccination coverage with the existing, low-efficacy vaccines is elusive. While flattening the outbreak if a significant proportion of the susceptible population is vaccinated with a low-efficacy vaccine, the overall infections may not be minimized if a small proportion of the population left unvaccinated when a highly efficacious vaccine becomes available. The optimal coverage for early vaccination could thus depend on several parameters including the efficacy of the currently available vaccines, arrival timing of a more effective vaccine and its efficacy, and the transmissibility of the disease. Here, we develop a deterministic system of differential equations to investigate the optimal vaccination coverage with a low-efficacy vaccine within the aforementioned parameter space. Despite simplifying assumptions, we illustrate that minimizing the overall infections does not necessarily correspond to the highest coverage of early vaccination. However, a high vaccination coverage, even with a low-efficacy vaccine, may still contribute to alleviating severe disease outcomes and reducing healthcare resource utilization. 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Trends in Biomathematics: Exploring Epidemics, Eco-Epidemiological Systems, and Optimal Control Strategies: Selected Works from the BIOMAT Consortium Lectures, Rio de Janeiro, Brazil, 2023. 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Waiting for the Perfect Vaccine. (2024) In: Trends in Biomathematics: Exploring Epidemics, Eco-Epidemiological Systems, and Optimal Control Strategies pp. 217-232<div class="BookChapter Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000778"><a href="/gui2/?type=authors&mode=browse&sel=10000778" target="_blank">Röst Gergely ✉ (<span class="authorship-author-name">Röst Gergely</span> <span class="authorAux-mtmt"> Differenciálegyenletek</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/Bolyai Institute (Institute of Mathematics)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhen Wang </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seyed M. Moghadas </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35244976" target="_blank">Waiting for the Perfect Vaccine</a></div> <div class="InBook"><div class="chapter-in">In:</div> <div class="authors"> <div class="autype autype-1"> <span class="author-name" >Mondaini Rubem P. </span> (eds.) </div> </div> <div class="booktitle"><a href="/gui2/?mode=browse&params=publication;35079304" target="_blank">Trends in Biomathematics: Exploring Epidemics, Eco-Epidemiological Systems, and Optimal Control Strategies : Selected Works from the BIOMAT Consortium Lectures, Rio de Janeiro, Brazil, 2023 </a></div> <span class="publishedAt">Cham: <span class="publishers">Springer Basel; Springer Switzerland</span>, <span class="page"> pp 217-232 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/978-3-031-59072-6_10" target="_blank" href="https://doi.org/10.1007/978-3-031-59072-6_10"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="https://link.springer.com/chapter/10.1007/978-3-031-59072-6_10" target="_blank" href="https://link.springer.com/chapter/10.1007/978-3-031-59072-6_10"> Other URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.researchgate.net/publication/378208827_Waiting_for_the_Perfect_Vaccine" target="_blank" href="https://www.researchgate.net/publication/378208827_Waiting_for_the_Perfect_Vaccine"> Other URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="34598" target="_blank" href="http://publicatio.bibl.u-szeged.hu/34598"> SZTE Publicatio </a> </span> </span> <span class="bookchapter-ids">Book link(s):</span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1007/978-3-031-59072-6" target="_blank" href="https://doi.org/10.1007/978-3-031-59072-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <span class="isbnOrIssn"> ISBN: </span> <a style="color:black" title="9783031590719" target="_blank" href="https://www.worldcat.org/search?q=isbn%3A9783031590719"> 9783031590719 </a> </span> <span class="id identifier oa_none" title="none"> <span class="isbnOrIssn"> ISBN: </span> <a style="color:black" title="9783031590726" target="_blank" href="https://www.worldcat.org/search?q=isbn%3A9783031590726"> 9783031590726 </a> </span> <span class="id identifier oa_none" title="none"> <span class="isbnOrIssn"> ISBN: </span> <a style="color:black" title="9783031590740" target="_blank" href="https://www.worldcat.org/search?q=isbn%3A9783031590740"> 9783031590740 </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://link.springer.com/10.1007/978-3-031-59072-6" target="_blank" href="https://link.springer.com/10.1007/978-3-031-59072-6"> Other URL </a> </span> </span> <div class="mtid"><span class="long-pub-mtid">Publication: 35244976</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="long-book-mtid">Book: 35079304</span> Core | <span class="type-subtype">Chapter in Book ( Study ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Egészségbiztonság Nemzeti Laboratórium(RRF-2.3.1-21-2022-00006) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2024.09.11. 09:42 Emese Nagyné Tari (SZTE admin5) </div> <div class="lockedBy">Centrally managed 2025.10.21. 10:41 András Balázs (MTMT Központ, admin) </div> </div> </div>