https://m2.mtmt.hu/ hun 2026-09-22 07:56 JournalArticle 35211857 VALIDATED true 0 false 2026-09-17T11:06:11.584+0000 2024-12-11T08:48:25.228+0000 2024-09-06T06:52:43.493+0000 true 10025780 Ostorházi Eszter /api/author/10025780 Author true 10025780 2026-09-17T11:00:11.707+0000 2026-09-17T11:00:11.707+0000 2024-12-11T08:48:25.418+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2025-06-04T23:42:22.094+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Stercz, Balázs The Roles of a Multidrug-Resistant Klebsiella pneumoniae High-Risk Clone and Its Resistance Plasmids on the Gastrointestinal Colonization and Host-Defense Effectors in the Gut true true /api/journal/10050685 REVIEWED true false 10050685 false 10050685 true 2079-6382 2079-6382 Journal FOREIGN 13 8 698 698 13 2024 The asymptomatic gastrointestinal colonization of multidrug-resistant (MDR) bacteria can lead to difficult-to-treat infections. We investigated the role of host factors influencing colonization in an orogastrical murine infection model using a CTX-M-15- and OXA-162-producing Klebsiella pneumoniae ST15 (MDR-KP) strain, as well as Escherichia coli J53 (EC) and E. coli transconjugants with an IncFII(K) plasmid carrying CTX-M-15 (EC-CTXM), and with an IncL plasmid carrying OXA-162 (EC-OXA) genes. The fecal bacterial count in colony-forming unit/gram stool (CFU/g) was determined by cultivation, IgA and defensin levels by ELISA, and gut microbiota by 16S rRNA analysis. The CFU was the lowest in EC, followed by EC-OXA and EC-CTXM, and the highest in the MDR-KP group. The IgA level in feces increased in MDR-KP, EC-CTXM, and EC-OXA, and did not change in EC. The beta-defensin 3 level markedly increased in all groups, with the highest values in MDR-KP and EC-CTXM. Alpha-defensin-5 increased in all groups especially in EC. In microbiota, the Bacteroidota phylum was dominant in MDR-KP, EC-CTXM, and EC-OXA, whereas Proteobacteria was dominant in EC. The Muribaculaceae family was significantly more common in the MDR-KP and EC-OXA groups, while the Lachnospiraceae family was dominant in the EC group. While fecal IgA levels positively correlated with colonizing bacterial CFU, the alpha-defensin 5 levels inversely correlated with CFUs and IgA levels. The presence of the IncFII(K) plasmid induced beta-defensin 3 production. The amounts of the Muribaculaceae family members exhibited a correlation with the IncL plasmid. The detected amounts of the Lachnospiraceae family indicated the protective role against the high-risk clone and the resistance plasmids’ dissemination. Our results suggest that not only the MDR-KP clone itself but also the resistance plasmids play a primary role in the colonization rate in the gastrointestinal tract. Both the MDR-KP clone as well as the IncFII(K) and IncL resistance plasmids provide survival and colonization benefits in the gut. 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2024-09-12T07:02:17.022+0000 HUN-REN-SE Humán Mikrobiota Kutatócsoport (SE / AOK / I / OMI); Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Információs Technológiai és Bionikai Kar (PPKE); Orvosi Mikrobiológiai Intézet (SE / AOK / I) 8 41 4 8 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118963087 /api/authorship/118963087 1 0.125 true false false Author 10024657 /api/author/10024657 Stercz Balázs true 10024657 true Stercz Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118963088 /api/authorship/118963088 2 0.125 false false false Author 10049211 /api/author/10049211 Domokos Judit true 10049211 true Domokos Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118963089 /api/authorship/118963089 3 0.125 false false false Author 10032930 /api/author/10032930 Dunai Zsuzsanna true 10032930 true Dunai Zsuzsanna A. true false 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/api/reference/57084078 45 10.1080/19490976.2023.2233679 false true Reference 57084079 /api/reference/57084079 46 10.3390/pathogens2010177 false true Reference 57084080 /api/reference/57084080 47 10.1128/JCM.01182-18 false true /api/publication/35211857 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024657"><a href="/gui2/?type=authors&mode=browse&sel=10024657" target="_blank">Stercz Balázs (<span class="authorship-author-name">Stercz Balázs</span> <span class="authorAux-mtmt"> mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Mikrobiológiai Intézet">OMI</span>/HUN-REN-SE Humán Mikrobiota Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049211"><a href="/gui2/?type=authors&mode=browse&sel=10049211" target="_blank">Domokos Judit (<span class="authorship-author-name">Domokos Judit</span> <span class="authorAux-mtmt"> orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Mikrobiológiai Intézet">OMI</span>/HUN-REN-SE Humán Mikrobiota Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032930"><a href="/gui2/?type=authors&mode=browse&sel=10032930" target="_blank">Dunai Zsuzsanna A. (<span class="authorship-author-name">Dunai Zsuzsanna</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Mikrobiológiai Intézet">OMI</span>/HUN-REN-SE Humán Mikrobiota Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034793"><a href="/gui2/?type=authors&mode=browse&sel=10034793" target="_blank">Makra Nóra (<span class="authorship-author-name">Makra Nóra</span> <span class="authorAux-mtmt"> genomika, biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049994"><a href="/gui2/?type=authors&mode=browse&sel=10049994" target="_blank">Juhász János (<span class="authorship-author-name">Juhász János</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet; <span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025780"><a href="/gui2/?type=authors&mode=browse&sel=10025780" target="_blank">Ostorházi Eszter (<span class="authorship-author-name">Ostorházi Eszter</span> <span class="authorAux-mtmt"> mikrobiológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021933"><a href="/gui2/?type=authors&mode=browse&sel=10021933" target="_blank">Kocsis Béla (<span class="authorship-author-name">Kocsis Béla</span> <span class="authorAux-mtmt"> mikrobiológia (Semmelweis Egyetem)</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003357"><a href="/gui2/?type=authors&mode=browse&sel=10003357" target="_blank">Szabó Dóra ✉ (<span class="authorship-author-name">Szabó Dóra</span> <span class="authorAux-mtmt"> Mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Mikrobiológiai Intézet">OMI</span>/HUN-REN-SE Humán Mikrobiota Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35211857" target="_blank">The Roles of a Multidrug-Resistant Klebsiella pneumoniae High-Risk Clone and Its Resistance Plasmids on the Gastrointestinal Colonization and Host-Defense Effectors in the Gut</a></div> <div> <span class="journal-title">ANTIBIOTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2079-6382">2079-6382</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2079-6382">2079-6382</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">8</span> <span class="page"> Paper 698. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/antibiotics13080698" target="_blank" href="https://doi.org/10.3390/antibiotics13080698"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="205315" target="_blank" href="https://real.mtak.hu/205315"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001307355100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001307355100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85202457540" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85202457540"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39199998" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39199998&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Infectious Diseases&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Microbiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Microbiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 3 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35211857&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35211857</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (HUN-REN-SU Human Microbiota Research Group No “0272”.), (BO/00286/22/5) </div> <div class="lastModified">Utolsó módosítás: 2024.12.11. 09:48 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2025.06.05. 01:42 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>