https://m2.mtmt.hu/ hun 2026-09-22 03:52 JournalArticle 35196655 VALIDATED true 0 false 2026-09-17T18:13:44.340+0000 2025-05-20T08:51:14.953+0000 2024-09-02T09:50:36.228+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-10-06T20:45:06.557+0000 2025-10-06T20:45:06.557+0000 2025-05-20T08:51:14.961+0000 true 10093409 Miskolczi Éva /api/admin/10093409 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Chacon, Enrique SENECA study: staging endometrial cancer based on molecular classification true true /api/journal/2041 REVIEWED true false 2041 false 2041 true 1048-891X 1525-1438 Journal FOREIGN 34 9 1313 1321 1313 9 2024 Objective Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups is essential. To evaluate SLN involvement in early-stage (International Federation of Gynecology and Obstetrics 2009 I & acirc;<euro>"II) endometrial cancer, considering molecular subtypes and new European Society of Gynaecological Oncology (ESGO) risk classification. Methods The SENECA study retrospectively reviewed data from 2139 & acirc;<euro>parts per thousand women with stage I & acirc;<euro>"II endometrial cancer across 66 centers in 16 countries. Patients underwent surgery with SLN assessment following ESGO guidelines between January 2021 and December 2022. Molecular analysis was performed on pre-operative biopsies or hysterectomy specimens. Results Among the 2139 patients, the molecular subgroups were as follows: 272 (12.7%) p53 abnormal (p53abn, 1191 (55.7%) non-specific molecular profile (NSMP), 581 (27.2%) mismatch repair deficient (MMRd), 95 (4.4%) POLE mutated (POLE-mut). Tracer diffusion was detected in, at least one side, in 97.2% of the cases; with a bilateral diffusion observed in 82.7% of the cases. By ultrastaging (90.7% of the cases) or one-step nucleic acid amplification (198 (9.3%) of the cases), 205 patients were identified with affected sentinel lymph nodes, representing 9.6% of the sample. Of these, 139 (67.8%) had low-volume metastases (including micrometastases, 42.9%; and isolated tumor cells, 24.9%) while 66 (32.2%) had macrometastases. Significant differences in SLN involvement were observed between molecular subtypes, with p53abn and MMRd groups having the highest rates (12.50% and 12.40%, respectively) compared with NSMP (7.80%) and POLE-mut (6.30%), (p=0.004); (p53abn, OR=1.69 (95% CI 1.11 to 2.56), p=0.014; MMRd, OR=1.67 (95% CI 1.21 to 2.31), p=0.002). Differences were also noted among ESGO risk groups (2.84% for low-risk patients, 6.62% for intermediate-risk patients, 21.63% for high & acirc;<euro>"intermediate risk patients, and 22.51% for high-risk patients; p<0.001). Conclusions Our study reveals significant differences in SLN involvement among patients with early-stage endometrial cancer based on molecular subtypes. This underscores the importance of considering molecular characteristics for accurate staging and optimal management decisions. true true 2024 true true true false true false NONE 2026-09-17 false 38 0 38 25 1 38 38 33 34 37 37 24 24 25 13 0 38 25 38 25 0 0 0 Folyóiratcikk Journal Article 24 38 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 23 13 23 13 2026 0 13 10 13 10 D1 false false false false 2024-09-01T09:53:21.518+0000 Szülészeti és Nőgyógyászati Klinika Üllői úti r... 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39153831&dopt=Abstract false true Keyword 12437 /api/keyword/12437 true 12437 true Keyword 17193 /api/keyword/17193 true 17193 true Keyword 19394 /api/keyword/19394 true 19394 true Keyword 1035549 /api/keyword/1035549 true 1035549 true SjrRating 11488231 /api/sjrrating/11488231 13 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2729 /api/classificationexternal/2729 true 2729 true D1 DIRECT true true /api/publication/35196655 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Chacon Enrique ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089733"><a href="/gui2/?type=authors&mode=browse&sel=10089733" target="_blank">Toth Richard (<span class="authorship-author-name">Tóth Richárd</span> <span class="authorAux-mtmt"> Szülészet, nőgyógyászat, nőgyógyászati onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; et al. (40) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">SENECA Working Grp</span> </div> <div><a target="_blank" href="/api/publication/35196655?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35196655" target="_blank">SENECA study: staging endometrial cancer based on molecular classification</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1048-891X">1048-891X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1525-1438">1525-1438</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">9</span> <span class="page"> pp 1313-1321 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1136/ijgc-2024-005711" target="_blank" href="https://doi.org/10.1136/ijgc-2024-005711"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001294263100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001294263100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85203204325" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85203204325"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39153831" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39153831&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Obstetrics and Gynecology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 38</span> | Független: 25 | Függő: 13 | Nem jelölt: 0 | WoS jelölt: 33 | Scopus jelölt:&nbsp;34 | WoS/Scopus jelölt:&nbsp;37 | DOI jelölt:&nbsp;38 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35196655</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.05.20. 10:51 Miskolczi Éva (SE_KK_Admin5_DME, admin) </div> </div></div>