https://m2.mtmt.hu/ hun 2026-09-22 15:49 JournalArticle 35195540 VALIDATED true Department of Neurosurgery, Nottingham University Hospitals, Nottingham, United Kingdom Stroke Trials Unit, Mental Health & Clinical Neurosciences, Queen's Medical Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom Department of Medicine, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia Faculty of Health Sciences, School of Medical Imaging, University of Sultan Zainal Abidin, Kuala Nerus, Malaysia Department of Acute Medicine, Nottingham University Hospitals, Nottingham, United Kingdom Mental Health and Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom Department of Neurology, Copenhagen University Hospital, Bispebjerg, Denmark Royal Derby Hospital, University Hospitals of Derby and Burton, Derby, United Kingdom School of Medicine, Keele University, Newcastle under Lyme, United Kingdom Stroke Research Centre, Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom Stroke Center and Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland Azienda Socio Sanitaria Territoriale di Mantova, Mantova, Italy College of Life Sciences, University of Leicester, Leicester, United Kingdom Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology, Semmelweis University, Budapest, Hungary Unidad de NeuroCríticos Hospital, Univ. Virgen Del Rocío, Sevilla, Spain Department of Neurology, Neurointensive Care- Stroke Center, Selcuk University, Faculty of Medicine, Konya, Turkey Export Date: 11 October 2024 CODEN: NRSRD Correspondence Address: Hollingworth, M.; University of NottinghamUnited Kingdom; email: milo.hollingworth@nottingham.ac.uk Correspondence Address: Sprigg, N.; Stroke Trials Unit, D floor South Block, QMC Campus, United Kingdom; email: nikola.sprigg@nottingham.ac.uk 0 false 2026-05-24T03:07:36.321+0000 2024-09-09T11:50:02.563+0000 2024-09-02T07:44:26.037+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2025-07-28T08:31:47.505+0000 2024-09-02T07:51:11.784+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Hollingworth, M. The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data from 121 Surgically Treated Participants from the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial true true /api/journal/3375 REVIEWED true false 3375 false 3375 true 0148-396X 1524-4040 Journal FOREIGN 95 3 605 616 605 12 2024 BACKGROUND AND OBJECTIVES: An important proportion of patients with spontaneous intracerebral hemorrhage (ICH) undergo neurosurgical intervention to reduce mass effect from large hematomas and control the complications of bleeding, including hematoma expansion and hydrocephalus. The Tranexamic acid (TXA) for hyperacute primary IntraCerebral Hemorrhage (TICH-2) trial demonstrated that tranexamic acid (TXA) reduces the risk of hematoma expansion. We hypothesized that TXA would reduce the frequency of surgery (primary outcome) and improve functional outcome at 90 days in surgically treated patients in the TICH-2 data set. METHODS: Participants enrolled in TICH-2 were randomized to placebo or TXA. Participants randomized to either TXA or placebo were analyzed for whether they received neurosurgery within 7 days and their characteristics, outcomes, hematoma volumes (HVs) were compared. Characteristics and outcomes of participants who received surgery were also compared with those who did not. RESULTS: Neurosurgery was performed in 5.2% of participants (121/2325), including craniotomy (57%), hematoma drainage (33%), and external ventricular drainage (21%). The number of patients receiving surgery who received TXA vs placebo were similar at 4.9% (57/1153) and 5.5% (64/1163), respectively (odds ratio [OR] 0.893; 95% CI 0.619-1.289; P-value =.545). TXA did not improve outcome compared with placebo in either surgically treated participants (OR 0.79; 95% CI 0.30-2.09; P =.64) or those undergoing hematoma evacuation by drainage or craniotomy (OR 1.19 95% 0.51-2.78; P-value =.69). Postoperative HV was not reduced by TXA (mean difference -8.97 95% CI -23.77, 5.82; P-value =.45). CONCLUSION: TXA was not associated with less neurosurgical intervention, reduced HV, or improved outcomes after surgery. 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hollingworth M. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Woodhouse L.J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Law Z.K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ali A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krishnan K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dineen R.A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Christensen H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >England T.J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roffe C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Werring D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Peters N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciccone A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Robinson T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Członkowska A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000800"><a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki D. (<span class="authorship-author-name">Bereczki Dániel</span> <span class="authorAux-mtmt"> Stroke</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Egea-Guerrero J.J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ozturk S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bath P.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sprigg N. ✉ </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">on behalf of the TICH-2 Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35195540" target="_blank">The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data from 121 Surgically Treated Participants from the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial</a></div> <div> <span class="journal-title">NEUROSURGERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0148-396X">0148-396X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1524-4040">1524-4040</a>)</span>: <span class="journal-volume">95</span> <span class="journal-issue">3</span> <span class="page"> pp 605-616 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1227/neu.0000000000002961" target="_blank" href="https://doi.org/10.1227/neu.0000000000002961"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001293866900016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001293866900016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85201438518" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85201438518"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38785451" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38785451&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Surgery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 3 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35195540&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35195540</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2024.09.09. 13:50 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Neurosurgery, Nottingham University Hospitals, Nottingham, United Kingdom Stroke Trials Unit, Mental Health & Clinical Neurosciences, Queen's Medical Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom Department of Medicine, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia ...</pre> </div></div>