Early COVID-19 XBB.1.5 Vaccine Effectiveness Against Hospitalisation Among Adults
Targeted for Vaccination, VEBIS Hospital Network, Europe, October 2023-January 2024
We conducted a multicentre test-negative case-control study covering the period from
October 2023 to January 2024 among adult patients aged >= 18 years hospitalised with
severe acute respiratory infection in Europe. We provide early estimates of the effectiveness
of the newly adapted XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation.
Vaccine effectiveness was 49% overall, ranging between 69% at 14-29 days and 40% at
60-105 days post vaccination. The adapted XBB.1.5 COVID-19 vaccines conferred protection
against COVID-19 hospitalisation in the first 3.5 months post vaccination, with VE
> 70% in older adults (>= 65 years) up to 1 month post vaccination.