https://m2.mtmt.hu/ hun 2026-09-23 05:33 JournalArticle 35172596 APPROVED true Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Department of Psychiatry and Neurology, Harvard Medical School and McLean Hospital, Boston, MA, United States Nyiro Gyula National Institute of Psychiatry and Addictology, Budapest, Hungary Cited By :2 Export Date: 6 March 2025 CODEN: BCPCA Correspondence Address: Gonda, X.Gyulai Pal utca 2., Hungary; email: gonda.xenia@semmelweis.hu 0 false 2026-06-30T09:23:06.480+0000 2026-05-29T20:00:15.124+0000 2024-08-16T08:48:30.207+0000 true 10003491 Gonda Xénia /api/author/10003491 Author true 10003491 2026-06-30T09:20:55.765+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Gonda, Xenia The emergence of antidepressant drugs targeting GABAA receptors A concise review true true /api/journal/686 REVIEWED true false 686 false 686 true 0006-2952 1873-2968 Journal FOREIGN 228 116481 116481 13 2024 Depression is among the most common psychiatric illnesses, which imposes a major socioeconomic burden on patients, caregivers, and the public health system. Treatment with classical antidepressants (e.g. tricyclic antidepressants and selective serotonine reuptake inhibitors), which primarily affect monoaminergic systems has several limitations, such as delayed onset of action and moderate efficacy in a relatively large proportion of depressed patients. Furthermore, depression is highly heterogeneus, and its different subtypes, including post-partum depression, involve distinct neurobiology, warranting a differential approach to pharmacotherapy. Given these shortcomings, the need for novel antidepressants that are superior in efficacy and faster in onset of action is fully justified. The development and market introduction of rapid-acting antidepressants has accelerated in recent years. Some of these new antidepressants act through the GABAergic system. In this review, we discuss the discovery, efficacy, and limitations of treatment with classic antidepressants. We provide a detailed discussion of GABAergic neurotransmission, with a special focus on GABAA receptors, and possible explanations for the mood-enhancing effects of GABAergic medications (in particular neurosteroids acting at GABAA receptors), and ultimately, we present the most promising molecules belonging to this family which are currently used in clinical practice or are in late phases of clinical development. true true 2024 true true true false true false NONE 2026-06-30 false 7 0 7 7 0 7 7 7 1 7 7 7 7 7 0 0 7 7 7 7 0 3 3 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 4 4 4 2026 0 3 3 3 3 Q1 false false false false 2024-10-03T08:37:02.883+0000 NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Nyírő Gyula Országos Pszichiátriai és Addiktoló...; Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 2 27 3 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118614647 /api/authorship/118614647 1 0.333 true false true Author 10003491 /api/author/10003491 Gonda Xénia true 10003491 true Gonda Xenia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118614648 /api/authorship/118614648 2 0.33333334 false false false Tarazi Frank I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118614649 /api/authorship/118614649 3 0.333 false true false Author 10023468 /api/author/10023468 Döme Péter true 10023468 true Dome Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26934555 /api/publicationidentifier/26934555 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.bcp.2024.116481 https://doi.org/10.1016/j.bcp.2024.116481 false true PublicationIdentifier 27582964 /api/publicationidentifier/27582964 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001320525800001 https://www.webofscience.com/wos/woscc/full-record/001320525800001 false true PublicationIdentifier 27005476 /api/publicationidentifier/27005476 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85201700182 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85201700182 false true PublicationIdentifier 26934554 /api/publicationidentifier/26934554 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39147329 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39147329&dopt=Abstract false true Keyword 759 /api/keyword/759 true 759 true Keyword 6441 /api/keyword/6441 true 6441 true Keyword 1042625 /api/keyword/1042625 true 1042625 true Keyword 1069715 /api/keyword/1069715 true 1069715 true Keyword 1142971 /api/keyword/1142971 true 1142971 true SjrRating 11443305 /api/sjrrating/11443305 57 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/35172596 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xenia ✉ (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tarazi Frank I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023468"><a href="/gui2/?type=authors&mode=browse&sel=10023468" target="_blank">Dome Peter (<span class="authorship-author-name">Döme Péter</span> <span class="authorAux-mtmt"> pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; Nyírő Gyula Országos Pszichiátriai és Addiktológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35172596" target="_blank">The emergence of antidepressant drugs targeting GABAA receptors : A concise review.</a></div> <div> <span class="journal-title">BIOCHEMICAL PHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0006-2952">0006-2952</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-2968">1873-2968</a>)</span>: <span class="journal-volume">228</span> <span class="page"> Paper 116481. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.bcp.2024.116481" target="_blank" href="https://doi.org/10.1016/j.bcp.2024.116481"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001320525800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001320525800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85201700182" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85201700182"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39147329" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39147329&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 7 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35172596&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35172596</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.05.29. 22:00 Döme Péter (Nyírő OPAI 4 admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Department of Psychiatry and Neurology, Harvard Medical School and McLean Hospital, Boston, MA, United States Nyiro...</pre> </div></div>