https://m2.mtmt.hu/ eng 2026-04-15 11:06 JournalArticle 35172447 VALIDATED true 0 false 2026-04-03T06:51:06.974+0000 2024-09-17T13:18:12.025+0000 2024-08-16T07:14:02.592+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-01-09T10:56:52.344+0000 2024-09-17T13:18:12.039+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:27.892+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Menyhart, Otilia Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI) true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 15 8441 8441 18 2024 The overall prognosis for colorectal cancer (CRC) remains challenging as the survival time varies widely, even in patients with the same stage of disease. Recent studies suggest prognostic relevance of the novel markers of systemic inflammation, the systemic immune-inflammation index (SII), and the systemic inflammation response index (SIRI). We conducted a comprehensive meta-analysis to assess the prognostic significance of the SII and the SIRI in CRC. We searched the relevant literature for observational studies, and random effects models were employed to conduct a statistical analysis using the metaanalysisonline.com platform. Pooled effect sizes were reported with hazard ratios (HRs) and corresponding 95% confidence intervals (CI). Data from 29 studies published between 2016 and 2024, comprising 10,091 participants, were included in our meta-analysis on SII. CRC patients with high SII levels had worse disease outcomes, which were associated with poor OS (HR: 1.75; 95% CI: 1.4-2.19) and poor PFS/DFS/RFS (HR: 1.25; 95% CI: 1.18-1.33). This increased risk of worse OS was present irrespective of the treatment strategy, sample size (<220 and >= 220), and cutoff used to define high and low SII (<550 and >= 550) groups. Based on data from five studies comprising 2362 participants, we found a strong association between the high SIRI and worse OS (HR: 2.65; 95% CI: 1.6-4.38) and DFS/RFS (HR: 2.04; 95% CI: 1.42-2.93). According to our results, both the SII and SIRI hold great promise as prognostic markers in CRC. Further validations are needed for their age- and stage-specific utility in the clinical routine. Funding 2042992 /api/funding/2042992 false true Funding 2044313 /api/funding/2044313 false true Funding 2042993 /api/funding/2042993 false true true true NATIONAL 2024 true true true false true false GOLD 2026-04-03 true https://doi.org/10.3390/ijms25158441 64 0 64 64 2 64 63 59 45 64 64 64 64 64 0 0 64 64 64 64 0 1 1 Folyóiratcikk Journal Article 24 64 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 5 5 5 5 2025 0 54 54 54 54 2026 0 5 5 5 5 D1 false 10000109,10045338 false false false 2024-08-15T07:18:10.429+0000 Biofizikai Intézet (PTE / ÁOK); Bioinformatika Tanszék (SE / AOK / I); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 3 27 3 3 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118611596 /api/authorship/118611596 1 0.333 true false false Author 10045338 /api/author/10045338 Menyhart Otilia true 10045338 true Menyhart Otilia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118611597 /api/authorship/118611597 2 0.333 false false false Author 10063867 /api/author/10063867 Fekete János Tibor true 10063867 true Fekete Janos Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118611598 /api/authorship/118611598 3 0.333 false true true Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Gyorffy Balazs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26934129 /api/publicationidentifier/26934129 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25158441 https://doi.org/10.3390/ijms25158441 false true PublicationIdentifier 26934130 /api/publicationidentifier/26934130 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001287907700001 https://www.webofscience.com/wos/woscc/full-record/001287907700001 false true PublicationIdentifier 26934132 /api/publicationidentifier/26934132 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85200921211 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85200921211 false true PublicationIdentifier 26934131 /api/publicationidentifier/26934131 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39126008 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39126008&dopt=Abstract false true Keyword 3375201 /api/keyword/3375201 true true SjrRating 11489344 /api/sjrrating/11489344 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 true 1605 true D1 DIRECT true true /api/publication/35172447 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10045338"><a href="/gui2/?type=authors&mode=browse&sel=10045338" target="_blank">Menyhart Otilia (<span class="authorship-author-name">Menyhart Otilia</span> <span class="authorAux-mtmt"> onkologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063867"><a href="/gui2/?type=authors&mode=browse&sel=10063867" target="_blank">Fekete Janos Tibor (<span class="authorship-author-name">Fekete János Tibor</span> <span class="authorAux-mtmt"> Prediktív biomarkerek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Gyorffy Balazs ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Biophysics; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35172447" target="_blank">Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">15</span> <span class="page"> Paper 8441. 18 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25158441" target="_blank" href="https://doi.org/10.3390/ijms25158441"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001287907700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001287907700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85200921211" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85200921211"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39126008" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39126008&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 64</span> | Independent citation: 64 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 59 | Number of citations in Scopus:&nbsp;45 | WoS/Scopus assigned:&nbsp;64 | Number of citations with DOI:&nbsp;63 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35172447&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35172447</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO, (Bolyai János Kutatási Ösztöndíj) Funder: HAS, (FK147194) </div> <div class="lastModified">Last Modified: 2024.09.17. 15:18 Anna Berhidi (SE_KK_Admin5_BA, admin) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> </div></div>