https://m2.mtmt.hu/ hun 2026-09-21 00:18 JournalArticle 35162229 APPROVED true Export Date: 14 January 2025 Correspondence Address: Ádány, R.; Hungarian Research Network University of Debrecen, Hungary; email: adany.roza@med.unideb.hu Correspondence Address: Pikó, P.; Department of Public Health and Epidemiology, Hungary; email: piko.peter@semmelweis.hu Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: National Research, Development and Innovation Office Funding details: RRF-2.3.1-21-2022-00006 Funding details: BO/00513/23/5, ÚNKP-23-5-DE-494 Funding details: Magyar Tudományos Akadémia, MTA, TK2016-78 Funding details: European Regional Development Fund, ERDF, GINOP-2.3.2-15-2016-00005 Funding details: Hungarian Research Network, HUN-REN, TKCS-2021/32, 135784 Funding text 1: This project was co-funded by the European Regional Development Fund (GINOP-2.3.2-15-2016-00005), the Hungarian Academy of Sciences (TK2016-78) and the Hungarian Research Network\\u2014HUN-REN (TKCS-2021/32). Project No. 135784 has also been implemented with the support of the National Research, Development, and Innovation Fund of Hungary, financed under the the K_20 programme. P.P. and R.\\u00C1. also work as team members of the National Laboratory for Health Security Hungary (RRF-2.3.1-21-2022-00006), supported by the National Research, Development, and Innovation Office (NKFIH). P.P. is a fellow of the New National Excellence Programme of the Ministry of Innovation and Technology, funded by the National Research, Development, and Innovation Fund of Hungary (\\u00DANKP-23-5-DE-494). P.P. was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00513/23/5). The authors declare no competing interests. 0 false 2026-05-24T01:37:44.215+0000 2026-02-18T13:40:27.895+0000 2024-08-07T07:05:42.052+0000 true 10061786 Pikó Péter /api/author/10061786 Author true 10061786 2026-04-21T11:39:27.346+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-06-02T18:19:59.884+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Al Ashkar, Habib Association of CETP Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 16 8587 8587 10 2024 Polymorphisms in the cholesteryl ester transfer protein (CETP) gene are known to be strongly associated with increased cardiovascular risk, primarily through their effects on the lipid profile and consequently on atherosclerotic risk. The acute heart rate response (AHRR) to physical activity is closely related to individual cardiovascular health. This study aimed to investigate the effect of CETP gene polymorphisms on AHRR. Our analysis examines the association of five single nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene with AHRR in 607 people from the Hungarian population. Individual AHRR in the present study was assessed using the YMCA 3-min step test and was estimated as the difference between resting and post-exercise heart rate, i.e., delta heart rate (ΔHR). To exclude the direct confounding effect of the CETP gene on the lipid profile, adjustments for TG and HDL-C levels, next to conventional risk factors, were applied in the statistical analyses. Among the examined five SNPs, two showed a significant association with lower ΔHR (rs1532624—Cdominant: B = −8.41, p < 0.001; rs708272—Gdominant: B = −8.33, p < 0.001) and reduced the risk of adverse AHRR (rs1532624—Cdominant: OR = 0.44, p = 0.004; rs708272—Gdominant: OR = 0.43, p = 0.003). Among the ten haplotypes, two showed significant association with lower ΔHR (H3—CAGCA: B = −6.81, p = 0.003; H9—CGGCG: B = −14.64, p = 0.015) and lower risk of adverse AHRR (H3—CAGCA: OR = 0.58, p = 0.040; H9—CGGCG: OR = 0.05, p = 0.009) compared to the reference haplotype (H1—AGACG). Our study is the first to report a significant association between CETP gene polymorphisms and AHRR. It also confirms that the association of the CETP gene with cardiovascular risk is mediated by changes in heart rate in response to physical activity, in addition to its effect on lipid profile. 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Ashkar Habib true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118511658 /api/authorship/118511658 2 0.2 false false false Author 10053985 /api/author/10053985 Kovács Nóra true 10053985 true Kovács Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118511659 /api/authorship/118511659 3 0.2 false false false Author 10031706 /api/author/10031706 Veres-Balajti Ilona true 10031706 true Veres-Balajti Ilona true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118511660 /api/authorship/118511660 4 0.2 false false true Author 1131057 /api/author/1131057 Ádány Róza true 1131057 true Ádány Róza true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118511661 /api/authorship/118511661 5 0.2 false true true Author 10061786 /api/author/10061786 Pikó Péter true 10061786 true Pikó Péter true false false 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/api/reference/56341746 48 false true /api/publication/35162229 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10104240"><a href="/gui2/?type=authors&mode=browse&sel=10104240" target="_blank">Al Ashkar Habib (<span class="authorship-author-name">Al Ashkar Habib</span> <span class="authorAux-mtmt"> Heart rate response</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053985"><a href="/gui2/?type=authors&mode=browse&sel=10053985" target="_blank">Kovács Nóra (<span class="authorship-author-name">Kovács Nóra</span> <span class="authorAux-mtmt"> egészségtudományok</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/HUN-REN-DE Népegészségügyi Kutatócsoport; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Népegészség- és Járványtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031706"><a href="/gui2/?type=authors&mode=browse&sel=10031706" target="_blank">Veres-Balajti Ilona (<span class="authorship-author-name">Veres-Balajti Ilona</span> <span class="authorAux-mtmt"> egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Egészségtudományi Kar">ETK</span>/<span title="Egészségtudományi Intézet">EgTudInt</span>/Fizioterápiás Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1131057"><a href="/gui2/?type=authors&mode=browse&sel=1131057" target="_blank">Ádány Róza ✉ (<span class="authorship-author-name">Ádány Róza</span> <span class="authorAux-mtmt"> Népegészségügy, genetikai epidemiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/HUN-REN-DE Népegészségügyi Kutatócsoport; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Népegészség- és Járványtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Epidemiológiai és Surveillance Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061786"><a href="/gui2/?type=authors&mode=browse&sel=10061786" target="_blank">Pikó Péter ✉ (<span class="authorship-author-name">Pikó Péter</span> <span class="authorAux-mtmt"> Népegészségügy</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Népegészség- és Járványtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Epidemiológiai és Surveillance Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35162229" target="_blank">Association of CETP Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">16</span> <span class="page"> Paper 8587. 10 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms25168587" target="_blank" href="https://doi.org/10.3390/ijms25168587"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="204824" target="_blank" href="http://real.mtak.hu/204824"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001307359100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001307359100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85202750993" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85202750993"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39201274" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39201274&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus 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népegészségü...(GINOP-2.3.2-15-2016-00005) Támogató: GINOP, (TK2016-78), (TKCS-2021/32), (135784) Támogató: NKFIH, Egészségbiztonság Nemzeti Laboratórium(RRF-2.3.1-21-2022-00006) Támogató: NKFIH, (BO/00513/23/5)) </div> <div class="lastModified">Utolsó módosítás: 2026.02.18. 14:40 Al Ashkar Habib (Heart rate response) </div> <div class="lockedBy">Központi kezelésű 2025.06.02. 20:19 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 14 January 2025 Correspondence Address: Ádány, R.; Hungarian Research Network University of Debrecen, Hungary; email: adany.roza@med.unideb.hu Correspondence Address: Pikó, P.; Department of Public Health and Epidemiology, Hungary; email: piko.peter@semmelweis.hu Funding details: Nemzeti Kutatási Fejlesztési és...</pre> </div></div>