https://m2.mtmt.hu/ eng 2026-06-25 05:14 Patent 35161458 ADMIN_APPROVED true 0 false 2026-05-26T09:00:00.184+0000 2025-11-12T21:06:13.386+0000 2024-08-06T11:05:20.723+0000 true 10014762 Varga Szilárd /api/author/10014762 Author true 10014762 2025-11-12T21:05:56.073+0000 2025-11-12T21:05:56.073+0000 2025-11-12T21:06:13.392+0000 true 10063514 Mikola Katalin /api/admin/10063514 Admin true 10063514 Admin 10063514 /api/admin/10063514 Mikola Katalin true 10063514 true 2025-10-29T20:35:29.915+0000 true true 26 26 /api/publicationtype/26 PublicationType 7 true 26 Patent true 21 International patent true 26 26 /api/publicationtype/26 PublicationType 7 true 26 Patent /api/subtype/21 Nemzetközi szabadalom SubType 758 true 21 true 1 /api/category/1 Category true 1 Reményi, Attila Cyclic designer scaffolds for the covalent targeting of proteins via michael addition 2024 Many biologically active natural products contain electrophilic Michael acceptor fragments. For example, curcumin and 4-hydroxyderricin contain an acyclic α,β-unsaturated ketone that alkylates cysteines. Other antitumor or anti-inflammatory herbal compounds such as Withaferin A or zerumbone contain cyclic α,β-unsaturated ketones and react with nucleophilic residues of proteins. These observations contributed to a paradigm shift in drug design and development in the last two decades: various drugs with covalent warhead have been developed and approved. Despite the apparent importance and success of covalent warheads in current drug design and developments, the applied warheads display a rather limited structural variance and complexity which automatically limits the attainable chemical space. Furthermore, to minimize possible side-reactions during the synthesis of drugs, the applied warheads are added appendages in the late-stage of the synthetic route, thus a warhead scaffold that can be synthetically easily varied using orthogonal chemistry and used as a tunable covalent warhead is still missing. Such a structurally more complex scaffold would be much more like the warheads of the natural products and is expected to be more selective in targeting nucleophiles found on the proteins. Moreover, owing to a larger contact surface, it might be more suitable for targeting shallow protein surfaces involved in protein-protein interactions. 2024 true true false true false NONE 2026-05-26 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 false false false false 2024-11-04T12:05:21.733+0000 Biomolekuláris Kölcsönhatások Kutatócsoport (HRN TTK / SZKI); Enzimológiai Intézet (TTK); Hevesy György Kémia Doktori Iskola (ELTE / TTK); Kémiai Biológiai Kutatócsoport (Lendület) (HRN TTK / SZKI); Molekuláris Élettudományi Intézet (HRN TTK); Organokatalízis Kutatócsoport (Lendület FLP Kut... 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false false Author 10060637 /api/author/10060637 Kállainé Szarka Eszter true 10060637 true Kállainé Szarka Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118509053 /api/authorship/118509053 14 0.071428575 false true Author 10014805 /api/author/10014805 Imre Timea true 10014805 true Imre Tímea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30154296 /api/publicationidentifier/30154296 PlainSource 39 /api/publicationsource/39 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Teljes dokumentum Full text @@@ true true 39 true IDENTICAL https://patentimages.storage.googleapis.com/68/44/94/659b76a52972b6/WO2024105420A2.pdf https://patentimages.storage.googleapis.com/68/44/94/659b76a52972b6/WO2024105420A2.pdf false true PublicationIdentifier 30154297 /api/publicationidentifier/30154297 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true https://patents.google.com/patent/WO2024105420A2/en?oq=WO2024105420A2 https://patents.google.com/patent/WO2024105420A2/en?oq=WO2024105420A2 false true PublicationIdentifier 30154298 /api/publicationidentifier/30154298 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2024105420&_cid=P10-MHWHMW-95068-1 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2024105420&_cid=P10-MHWHMW-95068-1 false true /api/publication/35161458 <div class="Patent Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10013627"><a href="/gui2/?type=authors&mode=browse&sel=10013627" target="_blank">Reményi Attila (<span class="authorship-author-name">Reményi Attila</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Organic Chemistry">IOC</span>/Biomolecular Interactions Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000777"><a href="/gui2/?type=authors&mode=browse&sel=10000777" target="_blank">Soós Tibor (<span class="authorship-author-name">Soós Tibor</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Organic Chemistry">IOC</span>/Organokatalízis Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060635"><a href="/gui2/?type=authors&mode=browse&sel=10060635" target="_blank">Póti Ádám Levente (<span class="authorship-author-name">Póti Ádám Levente</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Organic Chemistry">IOC</span>/Biomolecular Interactions Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094663"><a href="/gui2/?type=authors&mode=browse&sel=10094663" target="_blank">Bálint Dániel (<span class="authorship-author-name">Bálint Dániel</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Hevesy György PhD School of Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011246"><a href="/gui2/?type=authors&mode=browse&sel=10011246" target="_blank">Alexa Anita (<span class="authorship-author-name">Alexa Anita</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Organic Chemistry">IOC</span>/Biomolecular Interactions Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060638"><a href="/gui2/?type=authors&mode=browse&sel=10060638" target="_blank">Sok Péter Dániel (<span class="authorship-author-name">Sok Péter Dániel</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Torda Lili </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014762"><a href="/gui2/?type=authors&mode=browse&sel=10014762" target="_blank">Varga Szilárd (<span class="authorship-author-name">Varga Szilárd</span> <span class="authorAux-mtmt"> Szintetikus Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Organic Chemistry">IOC</span>/Organokatalízis Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ozsváth Kristóf </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Albert Krisztián </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014575"><a href="/gui2/?type=authors&mode=browse&sel=10014575" target="_blank">Palkó Roberta (<span class="authorship-author-name">Palkó Roberta</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Organic Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083858"><a href="/gui2/?type=authors&mode=browse&sel=10083858" target="_blank">Ember Orsolya (<span class="authorship-author-name">Ember Orsolya</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Organic Chemistry">IOC</span>/Chemical Biology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060637"><a href="/gui2/?type=authors&mode=browse&sel=10060637" target="_blank">Kállainé Szarka Eszter (<span class="authorship-author-name">Kállainé Szarka Eszter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014805"><a href="/gui2/?type=authors&mode=browse&sel=10014805" target="_blank">Imre Tímea (<span class="authorship-author-name">Imre Timea</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Centre for Structural Sciences</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35161458" target="_blank">Cyclic designer scaffolds for the covalent targeting of proteins via michael addition</a></div> <div class="patentnumber">Registration number: WO2024105420A2</div> <div class="casenumber">Case Number: PCT/HU2023/050079</div> <span class="patent-submission"> </span> <div class="publishedYear">Published year: (2024)</div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://patentimages.storage.googleapis.com/68/44/94/659b76a52972b6/WO2024105420A2.pdf" target="_blank" href="https://patentimages.storage.googleapis.com/68/44/94/659b76a52972b6/WO2024105420A2.pdf"> Full text </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://patents.google.com/patent/WO2024105420A2/en?oq=WO2024105420A2" target="_blank" href="https://patents.google.com/patent/WO2024105420A2/en?oq=WO2024105420A2"> Other URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2024105420&_cid=P10-MHWHMW-95068-1" target="_blank" href="https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2024105420&_cid=P10-MHWHMW-95068-1"> Other URL </a> </span> </span> <div class="mtid"><span class="long-pub-mtid">Publication: 35161458</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core | <span class="type-subtype">Protection forms ( International patent ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.11.12. 22:06 Katalin Mikola (MTMT 3, admin) </div> <div class="lockedBy">Centrally managed 2025.10.29. 21:35 Katalin Mikola (MTMT 3, admin) </div> </div></div>