Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Funder: NRDIO
(TKP2021-EGA-23) Funder: Ministry for Innovation and Technology
(János Bolyai Research Scholarship of the Hungarian Academy of Sciences.)
Mitral stenosis (MS) is a complex valvular pathology with significant clinical burden
even today. Its effect on the right heart is often overlooked, despite it playing
a considerable part in the symptomatic status. We enrolled 39 mitral valve stenosis
patients and 39 age- and gender-matched healthy controls. They underwent conventional,
speckle-tracking and 3D echocardiographic examinations. The 3D data was analyzed using
the ReVISION software to calculate RV functional parameters. In the MS group, 3D RV
ejection fraction (EF) (49 ± 7% vs. 61 ± 4%; p < 0.001), global circumferential (GCS)
(− 21.08 ± 5.64% vs. − 25.07 ± 4.72%; p = 0.001) and longitudinal strain (GLS) (−
16.60% ± 4.07% vs. − 23.32 ± 2.82%; p < 0.001) were reduced. When comparing RV contraction
patterns between controls, MS patients in sinus rhythm and those with atrial fibrillation,
radial (REF) (32.06 ± 5.33% vs. 23.62 ± 7.95% vs. 20.89 ± 6.92%; p < 0.001) and longitudinal
ejection fraction (LEF) (24.85 ± 4.06%; 17.82 ± 6.16% vs. 15.91 ± 4.09%; p < 0.001)
were decreased in both MS groups compared to controls; however, they were comparable
between the two MS subgroups. Anteroposterior ejection fraction (AEF) (29.16 ± 4.60%
vs. 30.87 ± 7.71% vs. 21.48 ± 6.15%; p < 0.001) showed no difference between controls
and MS patients in sinus rhythm, while it was lower in the MS group with atrial fibrillation.
Therefore, utilizing 3D echocardiography, we found distinct morphological and functional
alterations of the RV in MS patients.
