https://m2.mtmt.hu/ hun 2026-05-01 15:36 JournalArticle 35154279 VALIDATED true 0 false 2026-01-02T00:54:23.352+0000 2025-09-25T13:50:12.361+0000 2024-07-31T11:23:14.701+0000 true 10024239 Wacha András Ferenc /api/author/10024239 Author Wacha András Ferenc (Fizika) true 10024239 2025-11-11T14:14:28.091+0000 2025-02-13T08:50:51.702+0000 true 10073918 Kovács Marcell /api/admin/10073918 Admin Kovács Marcell (MTMT Közp., admin) true Admin 10013962 /api/admin/10013962 Vasvari Lilian (MTMT Központ, admin) Vasvari Lilian true 10013962 true 2025-04-24T15:35:05.010+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Augis, Luc true true /api/journal/2083 REVIEWED INTERNATIONAL JOURNAL OF PHARMACEUTICS 0378-5173 1873-3476 true false 2083 false 2083 true 0378-5173 1873-3476 Journal FOREIGN 662 124486 124486 16 2024 Cutaneous leishmaniasis, caused by Leishmania parasites, requires treatments with fewer side effects than those currently available. The development of a topical solution based on amphotericin B (AmB) was pursued. The considerable interest in deep eutectic solvents (DESs) and their remarkable advantages inspired the search for a suitable hydrophobic excipient. Various mixtures based on commonly used hydrogen bond donors (HBDs) and acceptors (HBAs) for DES preparations were explored. Initial physical and in-vitro screenings showed the potential of quaternary phosphonium salt-based mixtures. Through thermal analysis, it was determined that most of these mixtures did not exhibit eutectic behavior. X-ray scattering studies revealed a sponge-like nanoscale structure. The most promising formulation, based on a combination of trihexyl(tetradecyl)phosphonium chloride and 1-oleoyl-rac-glycerol, showed no deleterious effects through histological evaluation. AmB was fully solubilized at concentrations between 0.5 and 0.8 mg·mL−1, depending on the formulation. The monomeric state of AmB was observed by circular dichroism. In-vitro irritation tests demonstrated acceptable viability for AmB-based formulations up to 0.5 mg·mL−1. Additionally, an ex-vivo penetration study on pig ear skin revealed no transcutaneous passage, confirming AmB retention in healthy, unaffected skin. Funding 2049740 /api/funding/2049740 (TKP2021-EGA-13) false true Funding 2049741 /api/funding/2049741 (2020-1-1-2-PIACIKFI_2020-00021) Támogató: (NRDIO) - Hungary false true Funding 2049742 /api/funding/2049742 (FK146081) Támogató: (NRDIO) - Hungary false true true 2024 true true true false true false GOLD 2026-01-02 true https://doi.org/10.1016/j.ijpharm.2024.124486 3 0 3 2 1 3 3 2 2 3 3 2 2 2 1 0 3 2 3 2 0 3 3 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 2 3 2 Q1 false false false false 2024-10-29T12:23:15.713+0000 Anyag- és Környezetkémiai Intézet (HRN TTK); Biológiai Nanokémiai Kutatócsoport (HRN TTK / AKI) 1 15 2 9 0 true 10013962 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 118470852 /api/authorship/118470852 Augis, Luc 1 0.11111111 true false false Augis Luc true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470853 /api/authorship/118470853 Nguyễn, Cảnh Hưng 2 0.11111111 false false false Nguyễn Cảnh Hưng true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470854 /api/authorship/118470854 Ciseran, Cécile 3 0.11111111 false false false Ciseran Cécile true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470855 /api/authorship/118470855 Wacha, András [Wacha, András Ferenc (Fizika), szerző] Biológiai Nanokémiai Kutatócsoport (HRN TTK / AKI); Anyag- és Környezetkémiai Intézet (HRN TTK) 4 0.111 false false false Author 10024239 /api/author/10024239 Wacha András Ferenc (Fizika) Wacha András Ferenc true 10024239 true Wacha András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470856 /api/authorship/118470856 Mercier-Nomé, Françoise 5 0.11111111 false false false Mercier-Nomé Françoise true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470857 /api/authorship/118470857 Domenichini, Séverine 6 0.11111111 false false false Domenichini Séverine true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470858 /api/authorship/118470858 Sizun, Christina 7 0.11111111 false false false Sizun Christina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470859 /api/authorship/118470859 Fourmentin, Sophie 8 0.11111111 false false false Fourmentin Sophie true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118470860 /api/authorship/118470860 Legrand, François-Xavier ✉ 9 0.111 false true true Legrand François-Xavier true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 26888272 /api/publicationidentifier/26888272 DOI: 10.1016/j.ijpharm.2024.124486 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.ijpharm.2024.124486 https://doi.org/10.1016/j.ijpharm.2024.124486 false true PublicationIdentifier 27278533 /api/publicationidentifier/27278533 WoS: 001285788900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001285788900001 https://www.webofscience.com/wos/woscc/full-record/001285788900001 false true PublicationIdentifier 27538330 /api/publicationidentifier/27538330 REAL: 205792 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true IDENTICAL 205792 http://real.mtak.hu/205792 false true PublicationIdentifier 29901911 /api/publicationidentifier/29901911 Scopus: 85199956666 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 85199956666 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199956666 true true PublicationIdentifier 28390837 /api/publicationidentifier/28390837 PubMed: 39033940 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39033940 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39033940&dopt=Abstract false true Classification 10001 /api/classification/10001 Tudomány true true SjrRating 11491039 /api/sjrrating/11491039 sjr:Q1 (2024) Scopus - Pharmaceutical Science INTERNATIONAL JOURNAL OF PHARMACEUTICS 0378-5173 1873-3476 26 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 Scopus - Pharmaceutical Science true 3003 true Q1 DIRECT true true Reference 56147954 /api/reference/56147954 1. 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(2024) INTERNATIONAL JOURNAL OF PHARMACEUTICS 0378-5173 1873-3476 662<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Augis Luc </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nguyễn Cảnh Hưng </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciseran Cécile </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024239"><a href="/gui2/?type=authors&mode=browse&sel=10024239" target="_blank">Wacha András (<span class="authorship-author-name">Wacha András Ferenc</span> <span class="authorAux-mtmt"> Fizika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Anyag- és Környezetkémiai Intézet">AKI</span>/Biológiai Nanokémiai Kutatócsoport; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Anyag- és Környezetkémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mercier-Nomé Françoise </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Domenichini Séverine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sizun Christina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fourmentin Sophie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Legrand François-Xavier ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35154279" target="_blank">Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF PHARMACEUTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0378-5173">0378-5173</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-3476">1873-3476</a>)</span>: <span class="journal-volume">662</span> <span class="page"> Paper 124486. 16 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.ijpharm.2024.124486" target="_blank" href="https://doi.org/10.1016/j.ijpharm.2024.124486"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001285788900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001285788900001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="205792" target="_blank" href="http://real.mtak.hu/205792"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85199956666" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199956666"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39033940" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39033940&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35154279&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35154279</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2021-EGA-13), (2020-1-1-2-PIACIKFI_2020-00021) Támogató: (NRDIO) - Hungary, (FK146081) Támogató: (NRDIO) - Hungary </div> <div class="lastModified">Utolsó módosítás: 2025.09.25. 15:50 Wacha András Ferenc (Fizika) </div> <div class="lockedBy">Központi kezelésű 2025.04.24. 17:35 Vasvari Lilian (MTMT Központ, admin) </div> </div></div>