https://m2.mtmt.hu/ eng 2026-09-21 07:30 JournalArticle 35152388 VALIDATED true 0 false 2026-09-07T10:31:33.583+0000 2026-08-18T10:57:32.922+0000 2024-07-30T12:46:41.438+0000 true 10000649 Buday László /api/author/10000649 Author true 10000649 2026-08-18T10:57:33.534+0000 2026-08-18T10:57:33.534+0000 2024-08-29T14:52:55.524+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin true 2024-09-02T08:35:09.236+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10066925 /api/admin/10066925 Nemec Évi true true 2025-01-16T15:10:08.116+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 László, Loretta Unveiling epithelial plasticity regulation in lung cancer: Exploring the cross-talk among Tks4 scaffold protein partners true true /api/journal/3249 REVIEWED true false 3249 false 3249 true 1059-1524 1939-4586 Journal FOREIGN 35 8 ar111 ar111 19 2024 The epithelial-to-mesenchymal transition (EMT) represents a hallmark event in the evolution of lung cancer. This work aims to study a recently described EMT-regulating protein, Tks4, and to explore its potential as a prognostic biomarker in non–small cell lung cancer. In this study, we used CRISPR/Cas9 method to knockout (KO) Tks4 to study its functional roles in invadopodia formation, migration, and regulation of EMT marker expressions and we identified Tks4-interacting proteins. Tks4-KO A549 cells exhibited an EMT-like phenotype characterized by elongated morphology and increased expression of EMT markers. Furthermore, analyses of a large-scale lung cancer database and a patient-derived tissue array data revealed that the Tks4 mRNA level was decreased in more aggressive lung cancer stages. To understand the regulatory role of Tks4 in lung cancer, we performed a Tks4-interactome analysis via Tks4 immunoprecipitation-mass spectrometry on five different cell lines and identified CAPZA1 as a novel Tks4 partner protein. Thus, we propose that the absence of Tks4 leads to disruption of a connectome of multiple proteins and that the resulting undocking and likely mislocalization of signaling molecules impairs actin cytoskeleton rearrangement and activates EMT-like cell fate switches, both of which likely influence disease severity. 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style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10076637"><a href="/gui2/?type=authors&mode=browse&sel=10076637" target="_blank">László Loretta (<span class="authorship-author-name">László Loretta</span> <span class="authorAux-mtmt"> természettudomány</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073233"><a href="/gui2/?type=authors&mode=browse&sel=10073233" target="_blank">Kurilla Anita (<span class="authorship-author-name">Kurilla Anita</span> <span class="authorAux-mtmt"> Biológiai tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082437"><a href="/gui2/?type=authors&mode=browse&sel=10082437" target="_blank">Tilajka Álmos (<span class="authorship-author-name">Tilajka Álmos</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058394"><a href="/gui2/?type=authors&mode=browse&sel=10058394" target="_blank">Pancsa Rita (<span class="authorship-author-name">Pancsa Rita</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076635"><a href="/gui2/?type=authors&mode=browse&sel=10076635" target="_blank">Takács Tamás (<span class="authorship-author-name">Takács Tamás</span> <span class="authorAux-mtmt"> Természettudomány</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027845"><a href="/gui2/?type=authors&mode=browse&sel=10027845" target="_blank">Novák Julianna (<span class="authorship-author-name">Novák Julianna</span> <span class="authorAux-mtmt"> Genetika, immunológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000649"><a href="/gui2/?type=authors&mode=browse&sel=10000649" target="_blank">Buday László (<span class="authorship-author-name">Buday László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000695"><a href="/gui2/?type=authors&mode=browse&sel=10000695" target="_blank">Vas Virag ✉ (<span class="authorship-author-name">Vas Virág</span> <span class="authorAux-mtmt"> Őssejt biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35152388" target="_blank">Unveiling epithelial plasticity regulation in lung cancer: Exploring the cross-talk among Tks4 scaffold protein partners</a></div> <div> <span class="journal-title">MOLECULAR BIOLOGY OF THE CELL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1059-1524">1059-1524</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1939-4586">1939-4586</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">8</span> <span class="page"> Paper ar111. 19 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1091/mbc.E24-03-0103" target="_blank" href="https://doi.org/10.1091/mbc.E24-03-0103"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001293046200005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001293046200005"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="224311" target="_blank" href="https://real.mtak.hu/224311"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="120223" target="_blank" href="https://edit.elte.hu/handle/10831/120223"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85199815818" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199815818"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38985526" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38985526&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 3 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35152388&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35152388</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K124045) Funder: NKFIH, (FIEK_16-1-2016-0005), (HunProtExc2018-1.2.1-NKP-2018–00005), (2020–1.1.6-JÖVŐ-2021-00004), (FK142285), Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO, (BO/00174/22), (184018) Funder: Tempus P. F. </div> <div class="lastModified">Last Modified: 2026.08.18. 12:57 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2025.01.16. 16:10 Évi Nemec (MTMT Központi 3, admin) </div> </div></div>