https://m2.mtmt.hu/ eng 2026-05-31 15:01 JournalArticle 35139244 VALIDATED true Department of Internal Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary Third Department of Internal Medicine, Semmelweis Hospital of Borsod-Abauj-Zemplen County Central Hospital and University Teaching Hospital, Miskolc, Hungary Department of Health Informatics, Faculty of Health Sciences, University of Debrecen, Debrecen, Hungary Department of Internal Medicine and Oncology, Semmelweis University Faculty of Medicine, Budapest, Hungary Export Date: 30 October 2024 CODEN: POLNC Correspondence Address: Ferenc, S.; Department of Internal Medicine, Hungary; email: sztanekf@yahoo.com 0 false 2026-05-24T00:37:36.448+0000 2024-08-05T12:34:33.402+0000 2024-07-19T09:20:01.148+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin Márta Molnár-Taga (SE_AOK_1Bel_Onkol_Admin5_MTM, admin) true 2026-04-05T08:52:41.575+0000 2024-09-15T15:10:09.949+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Petö, A. true true /api/journal/10007440 REVIEWED PLOS ONE 1932-6203 true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 19 7 e0306482 e0306482 13 2024 Distal sensorimotor polyneuropathy (DSPN) is the earliest detectable and the most frequent microvascular complication in diabetes mellitus. Several studies have previously demonstrated correlations between cardiovascular risk factors in diabetic patients and independent risk factors for diabetic neuropathy. Our objective was to retrospectively analyze data from diabetic patients in the North-East region of Hungary who underwent neuropathy screening at the Diabetic Neuropathy Center, University of Debrecen, between 2017 and 2021. We aimed to investigate the correlations between cardiovascular risk factors and microvascular complications among patients with DSPN. The median age of the patients was 67 years, 59,6% were female, and 91,1% had type 2 diabetes. The prevalence of DSPN among the study subjects was 71.7%. A significantly longer duration of diabetes (p<0.01) was noted in patients with DSPN. Those with DSPN demonstrated a significantly higher HbA1c level (p<0.001) and a greater frequency of insulin use (p = 0.001). We observed a significantly elevated albumin/creatinine ratio (p<0.001) and a significantly lower eGFR (p<0.001) in patients with DSPN. Diabetic retinopathy exhibited a significantly higher prevalence in patients with DSPN (p<0.001). A higher prevalence of myocardial infarction (p<0.05), ischemic heart disease (p<0.001), peripheral arterial disease (p<0.05) and a history of atherosclerosis (p<0.05) was observed in patients with DSPN. In a multivariate logistic regression analysis, the following factors were independently associated with the presence of DSPN: higher HbA1c (OR:2.58, 95% CI:1.89-3.52, p<0.001), age (OR:1.03, 95% CI:1.01-1.05, p = 0.006), albumin/creatinine ratio above 3 mg/mmol (OR:1.23, 95% CI:1.06-1.45, p = 0.008), retinopathy (OR:6.06, 95% CI:1.33-27.53, p = 0.02), and composite cardiovascular endpoint (OR:1.95, 95% CI:1.19-3.19, p = 0.008). Our study revealed that age, elevated HbA1c levels, significant albuminuria, retinopathy, and cardiovascular complications may increase the risk of DSPN. Further investigation of these associations is necessary to understand the impact of patient characteristics during the treatment of diabetic neuropathy. © 2024 Petö et al. Funding 2042538 /api/funding/2042538 (K142273) false true Funding 2042539 /api/funding/2042539 (EFOP-3.6.2-16-2017-00009) false true true true 2024 true true true false true false GOLD 2026-05-24 false http://www.plosone.org/ 5 1 5 4 1 5 5 3 2 3 3 2 2 4 1 0 5 4 5 4 0 4 4 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 3 2 3 2 2026 0 1 1 1 1 Q1 A false 10043291 false false false 2024-07-28T07:59:21.682+0000 Belgyógyászati Intézet (DE / ÁOK); Belgyógyászati és Onkológiai Klinika (SE / AOK / K) 6 25 2 11 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 118350364 /api/authorship/118350364 Petö, A. 1 0.09090909 true false false Petö A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350365 /api/authorship/118350365 Tóth, L.I. [Tóth, László Imre (rezidens), author] 2 0.091 false false false Author 10094659 /api/author/10094659 László Imre Tóth (rezidens) Tóth László Imre true true Tóth L.I. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350366 /api/authorship/118350366 Hernyák, M. 3 0.09090909 false false false Hernyák M. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350367 /api/authorship/118350367 Lörincz, H. [Lőrincz, Hajnalka (Egészségtudományok), author] 4 0.09090909 false false false Author 10037740 /api/author/10037740 Hajnalka Lőrincz (Egészségtudományok) Lőrincz Hajnalka true 10037740 true Lörincz H. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350368 /api/authorship/118350368 Molnár, A. 5 0.09090909 false false false Molnár A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350369 /api/authorship/118350369 Nagy, A.C. 6 0.09090909 false false false Nagy A.C. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350370 /api/authorship/118350370 Lukács, M. 7 0.09090909 false false false Lukács M. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350371 /api/authorship/118350371 Kempler, P. [Kempler, Péter (Belgyógyászat, di...), author] Department of Internal Medicine and Oncology (SU / FM / C) 8 0.091 false false false Author 10024012 /api/author/10024012 Péter Kempler (Belgyógyászat, diabetológia) Kempler Péter true 10024012 true Kempler P. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350372 /api/authorship/118350372 Paragh, G. [Paragh, György (Belgyógyászat), author] Belgyógyászati Intézet (UD) 9 0.091 false false false Author 10003445 /api/author/10003445 György Paragh (Belgyógyászat) Paragh György true 10003445 true Paragh G. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 118350373 /api/authorship/118350373 Harangi, M. 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(2024) PLOS ONE 1932-6203 19 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Petö A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094659"><a href="/gui2/?type=authors&mode=browse&sel=10094659" target="_blank">Tóth L.I. (<span class="authorship-author-name">Tóth László Imre</span> <span class="authorAux-mtmt"> rezidens</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hernyák M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037740"><a href="/gui2/?type=authors&mode=browse&sel=10037740" target="_blank">Lörincz H. (<span class="authorship-author-name">Lőrincz Hajnalka</span> <span class="authorAux-mtmt"> Egészségtudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Molnár A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagy A.C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukács M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024012"><a href="/gui2/?type=authors&mode=browse&sel=10024012" target="_blank">Kempler P. (<span class="authorship-author-name">Kempler Péter</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003445"><a href="/gui2/?type=authors&mode=browse&sel=10003445" target="_blank">Paragh G. (<span class="authorship-author-name">Paragh György</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Belgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020547"><a href="/gui2/?type=authors&mode=browse&sel=10020547" target="_blank">Harangi M. (<span class="authorship-author-name">Harangi Mariann</span> <span class="authorAux-mtmt"> endokrinológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Belgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043291"><a href="/gui2/?type=authors&mode=browse&sel=10043291" target="_blank">Ferenc S. ✉ (<span class="authorship-author-name">Sztanek Ferenc</span> <span class="authorAux-mtmt"> belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Belgyógyászati Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35139244" target="_blank">Correlations between distal sensorimotor polyneuropathy and cardiovascular complications in diabetic patients in the North-Eastern region of Hungary</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">7</span> <span class="page"> Paper e0306482. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1371/journal.pone.0306482" target="_blank" href="https://doi.org/10.1371/journal.pone.0306482"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001267636600007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001267636600007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85197689034" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85197689034"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38959204" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38959204&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 4 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;5 (Not published:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35139244&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35139244</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (K142273), (EFOP-3.6.2-16-2017-00009) </div> <div class="lastModified">Last Modified: 2024.08.05. 14:34 Zsuzsa Reményiné Kállai (DE admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Internal Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary Third Department of Internal Medicine, Semmelweis Hospital of Borsod-Abauj-Zemplen County Central Hospital and University Teaching Hospital, Miskolc, Hungary Department of Health Informatics, Faculty of Health Sciences, University of Debrecen, Debrecen, ...</pre> </div></div>