https://m2.mtmt.hu/ eng 2026-05-31 10:17 JournalArticle 35134795 VALIDATED true Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Budapest, Hungary 1st Department of Medicine, Semmelweis University, Budapest, Hungary Dentist's Office, Budapest Dentcare, Budapest, Hungary Export Date: 22 August 2024 CODEN: JCMSE Correspondence Address: Szentpeteri, S.ria u. 52, Hungary; email: szentpeteriszofia@gmail.com 0 false 2026-05-24T00:27:34.550+0000 2024-10-30T10:47:06.742+0000 2024-07-16T09:04:07.117+0000 true 10067866 Szentpéteri Szófia Katalin /api/author/10067866 Author true 2026-01-23T09:56:42.856+0000 2026-01-23T09:56:42.856+0000 2024-10-30T10:47:07.035+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:14:31.681+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szentpeteri, Szofia Examination of certain single-nucleotide polymorphisms of interleukins 1A and 1B in medication-related osteonecrosis of the jaw — an ambirectional cohort study true true /api/journal/2409 REVIEWED true false 2409 false 2409 true 1010-5182 1878-4119 Journal FOREIGN 52 10 1133 1139 1133 7 2024 Aim The aim of this study was to examine particular single-nucleotide polymorphisms (IL-1A-889 C/T — rs1800587, IL-1B +3953 C/T — rs 1143634) of interleukins 1A and 1B in the development and prognosis of medication-related osteonecrosis of the jaw. Materials and methods DentiGen Parodontitis Tests were applied for collecting samples. This test is suitable for sampling oral mucosa cells in order to detect interleukins 1A and 1B single nucleotide polymorphisms (IL-1A−889, IL-1B+3953). Genetic samples were evaluated in the Istenhegyi Genediagnostic Center using the DNA-hybridization method. Genetic samples were collected in the patient group and the control group. The role of gene polymorphisms in the development of the disease was investigated by comparing the genetic results for the patient and control groups. The investigation of gene polymorphisms in disease prognosis is based on stage improvement, recovery, and relapses following treatment. Results In total, 91 patients with MRONJ and 59 healthy controls were included in the study. 51 patients in the patient group and 37 controls had unfavorable allelic variants. No association (Mp = 1.42, SDp = 0.496, Mc = 1.35, SDc = 0.482, p = 0.52) was found between unfavorable polymorphisms and the development of the MRONJ. In the patient group, surgical therapy was required in 79 cases. Stage improvement was detected in 78 cases, recovery in 67 cases, and relapse in 33 cases. No stage improvement was found in one case, recovery in nine cases, or relapse in 34 cases. Of the 79 patients requiring surgical therapy, 49 had unfavorable allelic variants. No connection was found between the polymorphisms examined and stage improvement (Mp = 1.37, SDp = 0.486, Mnp = 2, SDnp = –, p = 0.800) or recovery (Mp = 1.39, SDp = 0.491, Mnp = 1.44, SDnp = 0.527, p = 0.990). However, a significant association (Mp = 1.21, SDp = 0.415, Mnp = 1.58, SDnp = 0.502, p < 0.001) was found between relapses and the presence of unfavorable allelic variants. Conclusion Within the possible limitations of this study, it can be assumed that the analysis of certain single-nucleotide polymorphisms of interleukin-1 may have the potential to help define the risk stratification of MRONJ after surgical therapy. true true 2024 true true true false true false NONE 2026-05-24 false 5 0 5 3 2 4 5 3 3 3 3 1 1 3 2 0 5 3 5 3 0 4 4 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 1 2 1 2025 0 2 2 2 2 2026 0 1 0 1 0 Q1 false false false false 2024-10-14T09:19:18.134+0000 Arc- Állcsont- Szájsebészeti és Fogászati Klinika (SE / FOK); Belgyógyászati és Onkológiai Klinika (SE / AOK / K) 5 16 2 7 0 true 10003134 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118294669 /api/authorship/118294669 1 0.143 true false true Author 10067866 /api/author/10067866 Szentpéteri Szófia Katalin true true Szentpeteri Szofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118294670 /api/authorship/118294670 2 0.143 false false false Author 10024099 /api/author/10024099 Kósa János true 10024099 true Kosa Janos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118294671 /api/authorship/118294671 3 0.143 false false false Juhasz Huba Donat true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118294672 /api/authorship/118294672 4 0.143 false false false Deák György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118294673 /api/authorship/118294673 5 0.143 false false false Author 10012525 /api/author/10012525 Németh Zsolt true 10012525 true Nemeth Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118294674 /api/authorship/118294674 6 0.143 false false false Author 10012016 /api/author/10012016 Lakatos Péter true 10012016 true Lakatos Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118294675 /api/authorship/118294675 7 0.143 false true false Author 10045854 /api/author/10045854 Vaszilkó Mihály Tamás true 10045854 true Vaszilko Mihaly true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26837201 /api/publicationidentifier/26837201 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.1016/j.jcms.2024.06.007 https://doi.org/10.1016/j.jcms.2024.06.007 false true PublicationIdentifier 27706109 /api/publicationidentifier/27706109 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001334611400001 https://www.webofscience.com/wos/woscc/full-record/001334611400001 true true PublicationIdentifier 26880225 /api/publicationidentifier/26880225 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85199082361 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199082361 true true PublicationIdentifier 26880226 /api/publicationidentifier/26880226 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39033051 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39033051&dopt=Abstract true true Classification 12215 /api/classification/12215 true true Keyword 1658405 /api/keyword/1658405 true true Keyword 3489825 /api/keyword/3489825 true true Keyword 3489826 /api/keyword/3489826 true true SjrRating 11489282 /api/sjrrating/11489282 10 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3504 /api/classificationexternal/3504 true 3504 true Q1 DIRECT true true /api/publication/35134795 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067866"><a href="/gui2/?type=authors&mode=browse&sel=10067866" target="_blank">Szentpeteri Szofia ✉ (<span class="authorship-author-name">Szentpéteri Szófia Katalin</span> <span class="authorAux-mtmt"> arc-, állcsont-, szájsebészet, egészség-gazdasá...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024099"><a href="/gui2/?type=authors&mode=browse&sel=10024099" target="_blank">Kosa Janos (<span class="authorship-author-name">Kósa János</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Juhasz Huba Donat </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deák György </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012525"><a href="/gui2/?type=authors&mode=browse&sel=10012525" target="_blank">Nemeth Zsolt (<span class="authorship-author-name">Németh Zsolt</span> <span class="authorAux-mtmt"> Arc-állcsont-szájsebészet, onkológia, implantol...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012016"><a href="/gui2/?type=authors&mode=browse&sel=10012016" target="_blank">Lakatos Peter (<span class="authorship-author-name">Lakatos Péter</span> <span class="authorAux-mtmt"> Osteológia, endokrinológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045854"><a href="/gui2/?type=authors&mode=browse&sel=10045854" target="_blank">Vaszilko Mihaly (<span class="authorship-author-name">Vaszilkó Mihály Tamás</span> <span class="authorAux-mtmt"> Arc-Állcsont és Szájsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35134795" target="_blank">Examination of certain single-nucleotide polymorphisms of interleukins 1A and 1B in medication-related osteonecrosis of the jaw — an ambirectional cohort study</a></div> <div> <span class="journal-title">JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1010-5182">1010-5182</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1878-4119">1878-4119</a>)</span>: <span class="journal-volume">52</span> <span class="journal-issue">10</span> <span class="page"> pp 1133-1139 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1016/j.jcms.2024.06.007" target="_blank" href="https://doi.org/10.1016/j.jcms.2024.06.007"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001334611400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001334611400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85199082361" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199082361"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39033051" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39033051&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oral Surgery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Otorhinolaryngology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Surgery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 3 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35134795&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35134795</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Last Modified: 2024.10.30. 11:47 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:14 György Wolf (MTMT Központi admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Budapest, Hungary 1st Department of Medicine, Semmelweis University, Budapest, Hungary Dentist's Office, Budapest Dentcare, Budapest, Hungary Export Date: 22 August 2024 CODEN: JCMSE Correspondence...</pre> </div></div>