Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015)
Támogató: NKFIH
Szakterületek:
Tudomány
2‐Azabicyclo[2.2.1]hept‐5‐en‐3‐one (Vince lactam) is known to be a valuable building
block in synthetic organic chemistry and drug research. It is an important precursor
to access of some blockbuster antiviral drugs such as Carbovir or Abacavir as well
as other carbocyclic neuraminidase inhibitors as antiviral agents. The ring C=C bond
of the Vince lactam allows versatile chemical manipulations to create not only functionalized
γ‐lactams, but also γ‐amino acid derivatives with a cyclopentane framework. The aim
of the current account is to summarize the chemistry of Vince lactam, its synthetic
utility and application in organic and medicinal chemistry over the last decade.
