https://m2.mtmt.hu/ hun 2026-09-21 03:29 JournalArticle 35133550 VALIDATED true 0 false 2026-06-16T13:31:30.642+0000 2025-02-20T12:30:43.210+0000 2024-07-15T11:43:42.500+0000 true 10000148 Orbán Tamás I. /api/author/10000148 Author Orbán Tamás I. (Molekuláris sejtbiológia) true 10000148 2025-02-20T14:07:56.045+0000 2025-02-20T14:07:56.045+0000 2025-02-20T12:30:47.057+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2025-05-07T09:27:25.509+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Gál, Luca true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 14 7643 7643 14 2024 Mirtrons represent a subclass of microRNAs (miRNAs) that rely on the splicing machinery for their maturation. However, the molecular details of this Drosha-independent processing are still not fully understood; as an example, the Microprocessor complex cannot process the mirtronic pre-miRNA from the transcript even if splice site mutations are present. To investigate the influence of alternative splicing sites on mirtron formation, we generated Enhanced Green Fluorescent Protein (EGFP) reporters containing artificial introns to compare the processing of canonical miRNAs and mirtrons. Although mutations of both splice sites generated a complex pattern of alternative transcripts, mirtron formation was always severely affected as opposed to the normal processing of the canonical hsa-mir-33b miRNA. However, we also detected that while its formation was also hindered, the mirtron-derived hsa-mir-877-3p miRNA was less affected by certain mutations than the hsa-mir-877-5p species. By knocking down Drosha, we showed that this phenomenon is not dependent on Microprocessor activity but rather points toward the potential stability difference between the miRNAs from the different arms. Our results indicate that when the major splice sites are mutated, mirtron formation cannot be rescued by nearby alternative splice sites, and stability differences between 5p and 3p species should also be considered for functional studies of mirtrons. Funding 2044303 /api/funding/2044303 (ÚNKP-20-3-I-ELTE-473) false true Funding 2044304 /api/funding/2044304 (PC-II-12/2022) false true Funding 2044305 /api/funding/2044305 (ELKH-POC-2022-014) false true Funding 2044306 /api/funding/2044306 (PD121287) Támogató: NKFIH false true Funding 2044307 /api/funding/2044307 (FK124661) Támogató: NKFIH false true Funding 2044308 /api/funding/2044308 (2018-1.2.1-NKP-2018-00005) Támogató: NKFIH false true true 2024 true true true false true false GOLD 2026-06-16 true https://doi.org/10.3390/ijms25147643 3 0 3 3 0 3 3 2 2 3 3 3 3 3 0 0 3 3 3 3 0 5 5 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 false 10000148 false false false 2024-08-25T10:00:48.657+0000 Biológia Doktori Iskola (ELTE / TTK); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Génreguláció Kutatócsoport (HRN TTK / MÉI); Molekuláris Élettudományi Intézet (HRN TTK); Növénybiotechnológia Tanszék (MATE / GBI) 4 29 5 4 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 118269667 /api/authorship/118269667 Gál, Luca [Gál, Luca (Molekuláris sejtb...), szerző] Biológia Doktori Iskola (ELTE / TTK); Génreguláció Kutatócsoport (HRN TTK / MÉI) 1 0.25 true false false Author 10073902 /api/author/10073902 Gál Luca (Molekuláris sejtbiológia) Gál Luca true true Gál Luca true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118269668 /api/authorship/118269668 Schamberger, Anita [Schamberger, Anita (Molekuláris biológia), szerző] Génreguláció Kutatócsoport (HRN TTK / MÉI); Molekuláris Élettudományi Intézet (HRN TTK); Növénybiotechnológia Tanszék (MATE / GBI) 2 0.25 false false false Author 10029722 /api/author/10029722 Schamberger Anita (Molekuláris biológia) Schamberger Anita true 10029722 true Schamberger Anita true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118269669 /api/authorship/118269669 Wachtl, Gerda [Wachtl, Gerda Gabriella (Farmakológia, mol...), szerző] Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE) 3 0.25 false false false Author 10084586 /api/author/10084586 Wachtl Gerda Gabriella (Farmakológia, molekuláris genetika) Wachtl Gerda Gabriella true true Wachtl Gerda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118269670 /api/authorship/118269670 Orbán, Tamás I. ✉ [Orbán, Tamás I. (Molekuláris sejtb...), szerző] Biológia Doktori Iskola (ELTE / TTK); Génreguláció Kutatócsoport (HRN TTK / MÉI); Molekuláris Élettudományi Intézet (HRN TTK) 4 0.25 false true true Author 10000148 /api/author/10000148 Orbán Tamás I. (Molekuláris sejtbiológia) Orbán Tamás I. true 10000148 true Orbán Tamás I. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 26834320 /api/publicationidentifier/26834320 DOI: 10.3390/ijms25147643 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms25147643 https://doi.org/10.3390/ijms25147643 false true PublicationIdentifier 26992738 /api/publicationidentifier/26992738 WoS: 001277426700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001277426700001 https://www.webofscience.com/wos/woscc/full-record/001277426700001 false true PublicationIdentifier 32510231 /api/publicationidentifier/32510231 EDIT: 121301 SwordSource 92 /api/publicationsource/92 EDIT PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true EDIT EDIT https://edit.elte.hu/xmlui/handle/10831/@@@ true true 92 true GREEN true 121301 https://edit.elte.hu/xmlui/handle/10831/121301 false true PublicationIdentifier 26957523 /api/publicationidentifier/26957523 Scopus: 85199793707 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85199793707 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199793707 false true PublicationIdentifier 27289734 /api/publicationidentifier/27289734 PubMed: 39062888 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39062888 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39062888&dopt=Abstract false true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 55726724 /api/reference/55726724 1. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 14<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073902"><a href="/gui2/?type=authors&mode=browse&sel=10073902" target="_blank">Gál Luca (<span class="authorship-author-name">Gál Luca</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Biológia Doktori Iskola; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Génreguláció Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029722"><a href="/gui2/?type=authors&mode=browse&sel=10029722" target="_blank">Schamberger Anita (<span class="authorship-author-name">Schamberger Anita</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Génreguláció Kutatócsoport; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet; <span title="Magyar Agrár- és Élettudományi Egyetem">MATE</span>/<span title="Genetika és Biotechnológia Intézet">GBI</span>/Növénybiotechnológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084586"><a href="/gui2/?type=authors&mode=browse&sel=10084586" target="_blank">Wachtl Gerda (<span class="authorship-author-name">Wachtl Gerda Gabriella</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000148"><a href="/gui2/?type=authors&mode=browse&sel=10000148" target="_blank">Orbán Tamás I. ✉ (<span class="authorship-author-name">Orbán Tamás I.</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Biológia Doktori Iskola; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Génreguláció Kutatócsoport; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35133550" target="_blank">The Effect of Alternative Splicing Sites on Mirtron Formation and Arm Selection of Precursor microRNAs</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">14</span> <span class="page"> Paper 7643. 14 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25147643" target="_blank" href="https://doi.org/10.3390/ijms25147643"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001277426700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001277426700001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="121301" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/121301"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85199793707" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199793707"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39062888" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39062888&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 3 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35133550&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35133550</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-20-3-I-ELTE-473), (PC-II-12/2022), (ELKH-POC-2022-014), (PD121287) Támogató: NKFIH, (FK124661) Támogató: NKFIH, (2018-1.2.1-NKP-2018-00005) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2025.02.20. 13:30 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2025.05.07. 11:27 Vándor Andrea (VA, admin) </div> </div></div>