https://m2.mtmt.hu/ eng 2026-10-25 04:52 JournalArticle 35131536 VALIDATED true Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, H-1122, Hungary Department of Cardiology and Angiology, National Institute of Cardiovascular Diseases, Slovak Medical University, Bratislava, Slovakia Department of Electrocardiology, Medical University of Lodz, Lodz, Poland Department of Cardiology, Gottsegen National Cardiovascular Center, Budapest, Hungary Department of Cardiology, Central Hospital of Northern Pest-Military Hospital, Budapest, Hungary Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States Clinical Cardiovascular Research Center, University of Rochester, Rochester, NY, United States Export Date: 02 May 2025; Cited By: 2; Correspondence Address: B. Merkely; Heart and Vascular Center, Semmelweis University, Budapest, Varosmajor 68, H-1122, Hungary; email: merkely.study@gmail.com; CODEN: EUROC 0 false 2026-10-24T18:06:40.851+0000 2025-04-16T09:38:32.913+0000 2024-07-12T12:28:17.157+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-07-15T14:11:05.646+0000 2025-04-16T09:38:33.187+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Merkely, Béla Benefits of upgrading right ventricular to biventricular pacing in heart failure patients with atrial fibrillation true true /api/journal/22765 REVIEWED true false 22765 false 22765 true 1099-5129 1532-2092 Journal FOREIGN 26 7 euae179 euae179 10 2024 Recommendations on Cardiac Resynchronization Therapy (CRT) in patients with atrial fibrillation or flutter (AF) are based on less robust evidence than those in sinus rhythm. We aimed to assess the efficacy of CRT upgrade in the BUDAPEST-CRT Upgrade trial population by their baseline rhythm.Heart Failure patients with reduced ejection fraction (HFrEF) and priorly implanted pacemaker (PM) or implantable cardioverter defibrillator (ICD) and ≥20% right ventricular (RV) pacing burden were randomized to CRT-D upgrade (n=215) or ICD (n=145). Primary- [HF hospitalization (HFH), all-cause mortality, or <15% reduction of left ventricular end-systolic volume] and secondary outcomes were investigated.At enrolment 131 (36%) patients had AF, who had an increased risk for HFH as compared to those with sinus rhythm (SR) [adjusted hazard ratio (aHR) 2.99; 95%CI 1.26-7.13; P=0.013]. The effect of CRT-D upgrade was similar in patients with AF as in those with SR [AF adjusted odds ratio (aOR) 0.06; 95%CI 0.02 to 0.17; P‹0.001; SR aOR 0.13; 95%CI 0.07 to 0.27; P‹0.001; interaction P=0.29] during the mean follow-up time of 12.4 months. Also it decreased the risk of HFH or all-cause mortality (aHR 0.33; 95%CI 0.16 to 0.70; P=0.003; interaction P=0.17) and improved the echocardiographic response (left ventricular end-diastolic volume difference -49.21mL; 95%CI -69.10 to -29.32; P‹0.001; interaction P=0.21).In HFrEF patients with AF and PM/ICD with high RV pacing burden, CRT-D upgrade decreased the risk of HFH and improved reverse remodeling when compared to ICD, similar to that seen in patients in SR. 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Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 6 4 6 4 2026 0 12 11 12 11 D1 false false false false 2024-07-24T06:00:30.140+0000 Gottsegen György Országos Kardiovaszkuláris Int...; Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Repülõ- és Űrorvostani Tanszék (SE / AOK / K); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 11 41 5 16 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118252818 /api/authorship/118252818 1 0.063 true false true Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252819 /api/authorship/118252819 2 0.063 false false false Hatala Róbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252820 /api/authorship/118252820 3 0.063 false false false Author 10082362 /api/author/10082362 Pólos-Merkel Eperke Dóra true true Merkel Eperke true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252821 /api/authorship/118252821 4 0.063 false false false Szigeti Mátyás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252822 /api/authorship/118252822 5 0.063 false false false Author 10075136 /api/author/10075136 Veres Boglárka true true Veres Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252823 /api/authorship/118252823 6 0.063 false false false Author 10073175 /api/author/10073175 Fábián Alexandra true true Fábián Alexandra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252824 /api/authorship/118252824 7 0.063 false false false Author 10022852 /api/author/10022852 Osztheimer István true 10022852 true Osztheimer István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252825 /api/authorship/118252825 8 0.063 false false false Author 10013950 /api/author/10013950 Gellér László Alajos true 10013950 true Gellér László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252826 /api/authorship/118252826 9 0.0625 false false false Sasov Michal true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252827 /api/authorship/118252827 10 0.0625 false false false Wranicz Jerzy K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252828 /api/authorship/118252828 11 0.0625 false false false Author 10078612 /api/author/10078612 Földesi Csaba László true true Földesi Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252829 /api/authorship/118252829 12 0.063 false false false Author 10015391 /api/author/10015391 Duray Gábor Zoltán true 10015391 true Duray Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252830 /api/authorship/118252830 13 0.0625 false false false Solomon Scott D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252831 /api/authorship/118252831 14 0.063 false false false Author 10022835 /api/author/10022835 Kutyifa Valentina true 10022835 true Kutyifa Valentina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252832 /api/authorship/118252832 15 0.063 false true false Author 10035614 /api/author/10035614 Kovács Attila true 10035614 true Kovács Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118252833 /api/authorship/118252833 16 0.063 false true false Author 10027636 /api/author/10027636 Kosztin Annamária true 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journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/35131536 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla ✉ (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Aerospace Medicine Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hatala Róbert </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082362"><a href="/gui2/?type=authors&mode=browse&sel=10082362" target="_blank">Merkel Eperke (<span class="authorship-author-name">Pólos-Merkel Eperke Dóra</span> <span class="authorAux-mtmt"> orvos</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szigeti Mátyás </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075136"><a href="/gui2/?type=authors&mode=browse&sel=10075136" target="_blank">Veres Boglárka (<span class="authorship-author-name">Veres Boglárka</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073175"><a href="/gui2/?type=authors&mode=browse&sel=10073175" target="_blank">Fábián Alexandra (<span class="authorship-author-name">Fábián Alexandra</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022852"><a href="/gui2/?type=authors&mode=browse&sel=10022852" target="_blank">Osztheimer István (<span class="authorship-author-name">Osztheimer István</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013950"><a href="/gui2/?type=authors&mode=browse&sel=10013950" target="_blank">Gellér László (<span class="authorship-author-name">Gellér László Alajos</span> <span class="authorAux-mtmt"> Kardiológia, Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sasov Michal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wranicz Jerzy K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078612"><a href="/gui2/?type=authors&mode=browse&sel=10078612" target="_blank">Földesi Csaba (<span class="authorship-author-name">Földesi Csaba László</span> <span class="authorAux-mtmt"> kardiológia, elektrofiziológia</span>) </a> </span> <span class="author-affil">Gottsegen National Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015391"><a href="/gui2/?type=authors&mode=browse&sel=10015391" target="_blank">Duray Gábor (<span class="authorship-author-name">Duray Gábor Zoltán</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Solomon Scott D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022835"><a href="/gui2/?type=authors&mode=browse&sel=10022835" target="_blank">Kutyifa Valentina (<span class="authorship-author-name">Kutyifa Valentina</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035614"><a href="/gui2/?type=authors&mode=browse&sel=10035614" target="_blank">Kovács Attila<sup>**</sup> (<span class="authorship-author-name">Kovács Attila</span> <span class="authorAux-mtmt"> kardiológia, sportkardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027636"><a href="/gui2/?type=authors&mode=browse&sel=10027636" target="_blank">Kosztin Annamária (<span class="authorship-author-name">Kosztin Annamária</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35131536" target="_blank">Benefits of upgrading right ventricular to biventricular pacing in heart failure patients with atrial fibrillation</a></div> <div> <span class="journal-title">EUROPACE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1099-5129">1099-5129</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2092">1532-2092</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">7</span> <span class="page"> Paper euae179. 10 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/europace/euae179" target="_blank" href="https://doi.org/10.1093/europace/euae179"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001274847000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001274847000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85199674685" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199674685"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38979560" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38979560&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 19</span> | Independent citation: 16 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 16 | Number of citations in Scopus:&nbsp;18 | WoS/Scopus assigned:&nbsp;19 | Number of citations with DOI:&nbsp;19 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35131536&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35131536</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Funder: NRDIO, (RRF-2.3.1-21-2022-00003), János Bolyai Research Scholarship of the Hungarian Academy of Sciences, (TKP2021-NVA-12) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2025.04.16. 11:38 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, H-1122, Hungary Department of Cardiology and Angiology, National Institute of Cardiovascular Diseases, Slovak Medical University, Bratislava, Slovakia Department of Electrocardiology, Medical University of Lodz, Lodz, Poland Department of Cardiology,...</pre> </div></div>