https://m2.mtmt.hu/ hun 2026-09-22 00:50 JournalArticle 35131536 VALIDATED true Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, H-1122, Hungary Department of Cardiology and Angiology, National Institute of Cardiovascular Diseases, Slovak Medical University, Bratislava, Slovakia Department of Electrocardiology, Medical University of Lodz, Lodz, Poland Department of Cardiology, Gottsegen National Cardiovascular Center, Budapest, Hungary Department of Cardiology, Central Hospital of Northern Pest-Military Hospital, Budapest, Hungary Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States Clinical Cardiovascular Research Center, University of Rochester, Rochester, NY, United States Export Date: 02 May 2025; Cited By: 2; Correspondence Address: B. Merkely; Heart and Vascular Center, Semmelweis University, Budapest, Varosmajor 68, H-1122, Hungary; email: merkely.study@gmail.com; CODEN: EUROC 0 false 2026-07-29T12:17:50.664+0000 2025-04-16T09:38:32.913+0000 2024-07-12T12:28:17.157+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-07-15T14:11:05.646+0000 2025-04-16T09:38:33.187+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Merkely, Béla Benefits of upgrading right ventricular to biventricular pacing in heart failure patients with atrial fibrillation true true /api/journal/22765 REVIEWED true false 22765 false 22765 true 1099-5129 1532-2092 Journal FOREIGN 26 7 euae179 euae179 10 2024 Recommendations on Cardiac Resynchronization Therapy (CRT) in patients with atrial fibrillation or flutter (AF) are based on less robust evidence than those in sinus rhythm. We aimed to assess the efficacy of CRT upgrade in the BUDAPEST-CRT Upgrade trial population by their baseline rhythm.Heart Failure patients with reduced ejection fraction (HFrEF) and priorly implanted pacemaker (PM) or implantable cardioverter defibrillator (ICD) and ≥20% right ventricular (RV) pacing burden were randomized to CRT-D upgrade (n=215) or ICD (n=145). Primary- [HF hospitalization (HFH), all-cause mortality, or <15% reduction of left ventricular end-systolic volume] and secondary outcomes were investigated.At enrolment 131 (36%) patients had AF, who had an increased risk for HFH as compared to those with sinus rhythm (SR) [adjusted hazard ratio (aHR) 2.99; 95%CI 1.26-7.13; P=0.013]. The effect of CRT-D upgrade was similar in patients with AF as in those with SR [AF adjusted odds ratio (aOR) 0.06; 95%CI 0.02 to 0.17; P‹0.001; SR aOR 0.13; 95%CI 0.07 to 0.27; P‹0.001; interaction P=0.29] during the mean follow-up time of 12.4 months. Also it decreased the risk of HFH or all-cause mortality (aHR 0.33; 95%CI 0.16 to 0.70; P=0.003; interaction P=0.17) and improved the echocardiographic response (left ventricular end-diastolic volume difference -49.21mL; 95%CI -69.10 to -29.32; P‹0.001; interaction P=0.21).In HFrEF patients with AF and PM/ICD with high RV pacing burden, CRT-D upgrade decreased the risk of HFH and improved reverse remodeling when compared to ICD, similar to that seen in patients in SR. 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journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/35131536 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla ✉ (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Repülõ- és Űrorvostani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hatala Róbert </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082362"><a href="/gui2/?type=authors&mode=browse&sel=10082362" target="_blank">Merkel Eperke (<span class="authorship-author-name">Pólos-Merkel Eperke Dóra</span> <span class="authorAux-mtmt"> orvos</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szigeti Mátyás </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075136"><a href="/gui2/?type=authors&mode=browse&sel=10075136" target="_blank">Veres Boglárka (<span class="authorship-author-name">Veres Boglárka</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073175"><a href="/gui2/?type=authors&mode=browse&sel=10073175" target="_blank">Fábián Alexandra (<span class="authorship-author-name">Fábián Alexandra</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022852"><a href="/gui2/?type=authors&mode=browse&sel=10022852" target="_blank">Osztheimer István (<span class="authorship-author-name">Osztheimer István</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013950"><a href="/gui2/?type=authors&mode=browse&sel=10013950" target="_blank">Gellér László (<span class="authorship-author-name">Gellér László Alajos</span> <span class="authorAux-mtmt"> Kardiológia, Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sasov Michal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wranicz Jerzy K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078612"><a href="/gui2/?type=authors&mode=browse&sel=10078612" target="_blank">Földesi Csaba (<span class="authorship-author-name">Földesi Csaba László</span> <span class="authorAux-mtmt"> kardiológia, elektrofiziológia</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015391"><a href="/gui2/?type=authors&mode=browse&sel=10015391" target="_blank">Duray Gábor (<span class="authorship-author-name">Duray Gábor Zoltán</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Solomon Scott D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022835"><a href="/gui2/?type=authors&mode=browse&sel=10022835" target="_blank">Kutyifa Valentina (<span class="authorship-author-name">Kutyifa Valentina</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035614"><a href="/gui2/?type=authors&mode=browse&sel=10035614" target="_blank">Kovács Attila<sup>**</sup> (<span class="authorship-author-name">Kovács Attila</span> <span class="authorAux-mtmt"> kardiológia, sportkardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027636"><a href="/gui2/?type=authors&mode=browse&sel=10027636" target="_blank">Kosztin Annamária (<span class="authorship-author-name">Kosztin Annamária</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35131536" target="_blank">Benefits of upgrading right ventricular to biventricular pacing in heart failure patients with atrial fibrillation</a></div> <div> <span class="journal-title">EUROPACE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1099-5129">1099-5129</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2092">1532-2092</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">7</span> <span class="page"> Paper euae179. 10 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/europace/euae179" target="_blank" href="https://doi.org/10.1093/europace/euae179"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001274847000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001274847000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85199674685" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85199674685"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38979560" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38979560&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 15 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;17 | WoS/Scopus jelölt:&nbsp;17 | DOI jelölt:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35131536&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35131536</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, (RRF-2.3.1-21-2022-00003), János Bolyai Research Scholarship of the Hungarian Academy of Sciences, (TKP2021-NVA-12) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2025.04.16. 11:38 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, H-1122, Hungary Department of Cardiology and Angiology, National Institute of Cardiovascular Diseases, Slovak Medical University, Bratislava, Slovakia Department of Electrocardiology, Medical University of Lodz, Lodz, Poland Department of Cardiology,...</pre> </div></div>