https://m2.mtmt.hu/ eng 2026-10-23 03:05 JournalArticle 35130773 VALIDATED true 0 false 2026-10-22T08:51:45.281+0000 2026-04-13T09:47:55.177+0000 2024-07-12T07:53:24.706+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-05-19T12:28:33.589+0000 2026-05-19T12:28:33.589+0000 2026-01-08T10:38:05.605+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:01.860+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dubacher, Nicolo Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases true true /api/journal/4273 REVIEWED true false 4273 false 4273 true 0340-6245 2567-689X Journal FOREIGN 125 2 142 152 142 11 2025 Hereditary aortic diseases (hADs) increase the risk of aortic dissections and ruptures. Recently, we have established an objective approach to measure the rupture force of the murine aorta, thereby explaining the outcomes of clinical studies and assessing the added value of approved drugs in vascular Ehlers-Danlos syndrome (vEDS). Here, we applied our approach to six additional mouse hAD models. We used two mouse models (Fbn1C1041G and Fbn1mgR ) of Marfan syndrome (MFS) as well as one smooth-muscle-cell-specific knockout (SMKO) of Efemp2 and three CRISPR/Cas9-engineered knock-in models (Ltbp1, Mfap4, and Timp1). One of the two MFS models was subjected to 4-week-long losartan treatment. Per mouse, three rings of the thoracic aorta were prepared, mounted on a tissue puller, and uniaxially stretched until rupture. The aortic rupture force of the SMKO and both MFS models was significantly lower compared with wild-type mice but in both MFS models higher than in mice modeling vEDS. In contrast, the Ltbp1, Mfap4, and Timp1 knock-in models presented no impaired aortic integrity. As expected, losartan treatment reduced aneurysm formation but surprisingly had no impact on the aortic rupture force of our MFS mice. Our read-out system can characterize the aortic biomechanical integrity of mice modeling not only vEDS but also related hADs, allowing the aortic-rupture-force-focused comparison of mouse models. Furthermore, aneurysm progression alone may not be a sufficient read-out for aortic rupture, as antihypertensive drugs reducing aortic dilatation might not strengthen the weakened aortic wall. Our results may enable identification of improved medical therapies of hADs. Funding 2050457 /api/funding/2050457 false true Funding 2050458 /api/funding/2050458 false true true true INTERNATIONAL 2024 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1055/s-0044-1787957 5 0 5 5 0 5 5 5 5 5 5 5 5 5 0 0 5 5 5 5 0 0 0 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 2 2 2 2 2026 0 2 2 2 2 Q1 false false false false 2024-10-10T07:53:30.323+0000 Molekuláris Neuroendokrinológiai Kutatócsoport (HRN KOKI); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 3 18 2 13 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118248767 /api/authorship/118248767 1 0.07692308 true false false Dubacher Nicolo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248768 /api/authorship/118248768 2 0.07692308 false false false Sugiyama Kaori true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248769 /api/authorship/118248769 3 0.07692308 false false false Smith Jeffrey D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248770 /api/authorship/118248770 4 0.07692308 false false false Nussbaumer Vanessa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248771 /api/authorship/118248771 5 0.077 false false false Author 10085280 /api/author/10085280 Csonka Máté true true Csonka Máté true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248772 /api/authorship/118248772 6 0.07692308 false false false Author 10013609 /api/author/10013609 Ferenczi Szilamér true 10013609 true Ferenczi Szilamér true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248773 /api/authorship/118248773 7 0.07692308 false false false Author 10009124 /api/author/10009124 Kovács Krisztina true 10009124 true Kovács Krisztina J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248774 /api/authorship/118248774 8 0.07692308 false false false Caspar Sylvan M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248775 /api/authorship/118248775 9 0.07692308 false false false Lamberti Lisa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248776 /api/authorship/118248776 10 0.07692308 false false false Meienberg Janine true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248777 /api/authorship/118248777 11 0.077 false true false Yanagisawa Hiromi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248778 /api/authorship/118248778 12 0.077 false true false Sheppard Mary B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118248779 /api/authorship/118248779 13 0.077 false true true Matyas Gabor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26827508 /api/publicationidentifier/26827508 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true 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src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Dubacher Nicolo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sugiyama Kaori </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Smith Jeffrey D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nussbaumer Vanessa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085280"><a href="/gui2/?type=authors&mode=browse&sel=10085280" target="_blank">Csonka Máté (<span class="authorship-author-name">Csonka Máté</span> <span class="authorAux-mtmt"> Szív- és érrendszeri betegségek élettana és kli...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013609"><a href="/gui2/?type=authors&mode=browse&sel=10013609" target="_blank">Ferenczi Szilamér (<span class="authorship-author-name">Ferenczi Szilamér</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009124"><a href="/gui2/?type=authors&mode=browse&sel=10009124" target="_blank">Kovács Krisztina J (<span class="authorship-author-name">Kovács Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Caspar Sylvan M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lamberti Lisa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Meienberg Janine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yanagisawa Hiromi<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sheppard Mary B<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matyas Gabor ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35130773" target="_blank">Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases</a></div> <div> <span class="journal-title">THROMBOSIS AND HAEMOSTASIS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0340-6245">0340-6245</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2567-689X">2567-689X</a>)</span>: <span class="journal-volume">125</span> <span class="journal-issue">2</span> <span class="page"> pp 142-152 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1055/s-0044-1787957" target="_blank" href="https://doi.org/10.1055/s-0044-1787957"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001260154300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001260154300001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243202" target="_blank" href="https://real.mtak.hu/243202"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85211810908" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85211810908"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38950604" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38950604&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Hematology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 5 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35130773</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI)(K01 HL149984), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for th...(JP20H03762) </div> <div class="lastModified">Last Modified: 2026.04.13. 11:47 Márta Turek (KOKI admin 4) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>