https://m2.mtmt.hu/ eng 2026-10-23 12:00 JournalArticle 35082580 VALIDATED true 0 false 2026-10-08T08:46:25.981+0000 2026-05-11T13:09:38.686+0000 2024-07-03T09:31:18.135+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true 2026-05-11T13:09:38.867+0000 2026-05-11T13:09:38.867+0000 2024-10-29T10:33:27.817+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mészáros, Szilvia Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 46 6 6419 6433 6419 15 2024 There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS] and quantitative ultrasound index [QUI]) is rarely investigated. We aimed to disentangle the role of genetic, shared and unique environmental factors on TBS and QUI among Hungarian twins. Our study includes 82 twin (48 monozygotic, 33 same-sex dizygotic) pairs from the Hungarian Twin Registry. TBS was determined by DXA, QUI by calcaneal bone ultrasound. To estimate the genetic and environmental effects, we utilized ACE-variance decomposition. For the unadjusted model of TBS, an AE model provided the best fit with > 80% additive genetic heritability. Adjustment for age, sex, BMI and smoking status improved model fit with 48.0% of total variance explained by independent variables. Furthermore, there was a strong dominant genetic effect (73.7%). In contrast, unadjusted and adjusted models for QUI showed an AE structure. Adjustments improved model fit and 25.7% of the total variance was explained by independent variables. Altogether 70–90% of the variance in QUI was related to additive genetic influences. We found a strong genetic heritability of bone quality in unadjusted models. Half of the variance of TBS was explained by age, sex and BMI. Furthermore, the adjusted model suggested that the genetic component of TBS could be dominant or an epistasis could be present. In contrast, independent variables explained only a quarter of the variance of QUI and the additive heritability explained more than half of all the variance. Funding 2041955 /api/funding/2041955 false true Funding 2041956 /api/funding/2041956 false true true true 2024 true true true false true false NONE 2026-10-08 false 3 0 3 2 1 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 2 2 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 2 1 2 1 D1 false 10024020 false false false 2024-10-01T09:38:48.390+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Doktori Iskola (SE); Gyermekgyógyászati Klinika (SE / AOK / K); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Orvosi Képalkotó Klinika (SE / AOK / K) 12 30 5 13 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 118144018 /api/authorship/118144018 1 0.077 true false true Author 10024020 /api/author/10024020 Mészáros Szilvia true 10024020 true Mészáros Szilvia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144019 /api/authorship/118144019 2 0.077 false false false Author 10070362 /api/author/10070362 Piroska Márton true true Piroska Márton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144020 /api/authorship/118144020 3 0.077 false false false Author 10093548 /api/author/10093548 Leel-Őssy Tamás true true Leel-Őssy Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144021 /api/authorship/118144021 4 0.077 false false false Author 10023716 /api/author/10023716 Tárnoki Ádám Domonkos true 10023716 true Tárnoki Ádám Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144022 /api/authorship/118144022 5 0.077 false false false Author 10023718 /api/author/10023718 Tárnoki Dávid László true 10023718 true Tárnoki Dávid László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144023 /api/authorship/118144023 6 0.077 false false false Author 10070296 /api/author/10070296 Jokkel Zsófia true true Jokkel Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144024 /api/authorship/118144024 7 0.077 false false false Author 10072148 /api/author/10072148 Szabó Helga true true Szabó Helga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144025 /api/authorship/118144025 8 0.077 false false false Author 10023608 /api/author/10023608 Hosszú Éva true 10023608 true Hosszú Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144026 /api/authorship/118144026 9 0.07692308 false false false Csupor Emőke true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144027 /api/authorship/118144027 10 0.077 false false false Author 10078681 /api/author/10078681 Kollár Réka true true Kollár Réka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144028 /api/authorship/118144028 11 0.077 false false false Author 10070303 /api/author/10070303 Kézdi Árpád true true Kézdi Árpád true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144029 /api/authorship/118144029 12 0.077 false true false Author 10024030 /api/author/10024030 Tabák Ádám true 10024030 true Tabák Ádám G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 118144030 /api/authorship/118144030 13 0.077 false true false Author 10024005 /api/author/10024005 Horváth Csaba true 10024005 true Horváth Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26755211 /api/publicationidentifier/26755211 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.1007/s11357-024-01265-2 https://doi.org/10.1007/s11357-024-01265-2 false true PublicationIdentifier 26829536 /api/publicationidentifier/26829536 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true 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SjrRating 11505857 /api/sjrrating/11505857 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true /api/publication/35082580 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024020"><a href="/gui2/?type=authors&mode=browse&sel=10024020" target="_blank">Mészáros Szilvia ✉ (<span class="authorship-author-name">Mészáros Szilvia</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070362"><a href="/gui2/?type=authors&mode=browse&sel=10070362" target="_blank">Piroska Márton (<span class="authorship-author-name">Piroska Márton</span> <span class="authorAux-mtmt"> Radiológia, Nukleáris Medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10093548"><a href="/gui2/?type=authors&mode=browse&sel=10093548" target="_blank">Leel-Őssy Tamás (<span class="authorship-author-name">Leel-Őssy Tamás</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023716"><a href="/gui2/?type=authors&mode=browse&sel=10023716" target="_blank">Tárnoki Ádám Domonkos (<span class="authorship-author-name">Tárnoki Ádám Domonkos</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023718"><a href="/gui2/?type=authors&mode=browse&sel=10023718" target="_blank">Tárnoki Dávid László (<span class="authorship-author-name">Tárnoki Dávid László</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070296"><a href="/gui2/?type=authors&mode=browse&sel=10070296" target="_blank">Jokkel Zsófia (<span class="authorship-author-name">Jokkel Zsófia</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072148"><a href="/gui2/?type=authors&mode=browse&sel=10072148" target="_blank">Szabó Helga (<span class="authorship-author-name">Szabó Helga</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023608"><a href="/gui2/?type=authors&mode=browse&sel=10023608" target="_blank">Hosszú Éva (<span class="authorship-author-name">Hosszú Éva</span> <span class="authorAux-mtmt"> Gyermekgyógyászat endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Csupor Emőke </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078681"><a href="/gui2/?type=authors&mode=browse&sel=10078681" target="_blank">Kollár Réka (<span class="authorship-author-name">Kollár Réka</span> <span class="authorAux-mtmt"> Belgyógyászat , endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070303"><a href="/gui2/?type=authors&mode=browse&sel=10070303" target="_blank">Kézdi Árpád (<span class="authorship-author-name">Kézdi Árpád</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024030"><a href="/gui2/?type=authors&mode=browse&sel=10024030" target="_blank">Tabák Ádám G.<sup>**</sup> (<span class="authorship-author-name">Tabák Ádám</span> <span class="authorAux-mtmt"> belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024005"><a href="/gui2/?type=authors&mode=browse&sel=10024005" target="_blank">Horváth Csaba (<span class="authorship-author-name">Horváth Csaba</span> <span class="authorAux-mtmt"> Belgyógyászat, endokrinológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35082580" target="_blank">Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">46</span> <span class="journal-issue">6</span> <span class="page"> pp 6419-6433 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1007/s11357-024-01265-2" target="_blank" href="https://doi.org/10.1007/s11357-024-01265-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001261159400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001261159400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85197436451" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85197436451"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38955996" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38955996&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 2 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35082580&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35082580</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (TKP2021-NKTA-47) </div> <div class="lastModified">Last Modified: 2026.05.11. 15:09 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> </div></div>