https://m2.mtmt.hu/ hun 2026-09-21 19:43 JournalArticle 35079836 VALIDATED true Funding Agency and Grant Number: Hungarian Science Foundation [OTKA K147337]; Semmelweis University [STIA-KFI-2020/132257/AOMBT/2020]; Department of Molecular Biology of the Semmelweis University [2023/1] Funding text: The research in the authors' laboratory was funded by grants from the Hungarian Science Foundation (OTKA K147337) to Csaba Soti, from the Semmelweis University (STIA-KFI-2020/132257/AOMBT/2020) to Csaba Soti, and from the Department of Molecular Biology of the Semmelweis University (Baron Munchausen Program 2023/1) to Csaba Soti. 0 false 2026-09-18T08:20:10.663+0000 2026-04-21T09:01:16.264+0000 2024-07-01T13:21:15.056+0000 true 10063746 Hajdú Gábor /api/author/10063746 Author Hajdú Gábor (Molekuláris biológia) true 10063746 2026-06-24T15:16:47.248+0000 2024-07-24T06:09:02.958+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Hajdú, Gábor true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 13 7034 7034 21 2024 Infections, such as that by the multiresistant opportunistic bacterial pathogen Pseudomonas aeruginosa, may pose a serious health risk, especially on vulnerable patient populations. The nematode Caenorhabditis elegans provides a simple organismal model to investigate both pathogenic mechanisms and the emerging role of innate immunity in host protection. Here, we review the virulence and infection strategies of P. aeruginosa and host defenses of C. elegans. We summarize the recognition mechanisms of patterns of pathogenesis, including novel pathogen-associated molecular patterns and surveillance immunity of translation, mitochondria, and lysosome-related organelles. We also review the regulation of antimicrobial and behavioral defenses by the worm’s neuroendocrine system. We focus on how discoveries in this rich field align with well-characterized evolutionary conserved protective pathways, as well as on potential crossovers to human pathogenesis and innate immune responses. Funding 2041903 /api/funding/2041903 (K147337) Támogató: OTKA false true Funding 2041904 /api/funding/2041904 (STIA-KFI-2020/132257/AOMBT/2020) false true Funding 2041905 /api/funding/2041905 (Baron Munchausen Program 2023/1) false true true 2024 true true true false true false GOLD 2026-09-18 false http://www.mdpi.com/journal/ijms 14 0 14 14 0 14 14 13 14 14 14 14 14 14 0 0 14 14 14 14 0 5 5 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 7 7 7 7 2026 0 6 6 6 6 D1 false 10012506 false false false 2024-07-01T07:25:28.274+0000 Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 8 1 3 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 118131673 /api/authorship/118131673 Hajdú, Gábor ✉ [Hajdú, Gábor (Molekuláris biológia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.333 true false true Author 10063746 /api/author/10063746 Hajdú Gábor (Molekuláris biológia) Hajdú Gábor true 10063746 true Hajdú Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118131674 /api/authorship/118131674 Szathmári, Csenge [Szathmári, Csenge (Molekuláris biológia), szerző] 2 0.33333334 false false false Author 10098941 /api/author/10098941 Szathmári Csenge (Molekuláris biológia) Szathmári Csenge true true Szathmári Csenge true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 118131675 /api/authorship/118131675 Sőti, Csaba ✉ [Sőti, Csaba (Biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 0.333 false true true Author 10012506 /api/author/10012506 Sőti Csaba (Biokémia, molekuláris biológia) Sőti Csaba true 10012506 true Sőti Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 26748724 /api/publicationidentifier/26748724 DOI: 10.3390/ijms25137034 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms25137034 https://doi.org/10.3390/ijms25137034 false true PublicationIdentifier 26873191 /api/publicationidentifier/26873191 WoS: 001270267500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001270267500001 https://www.webofscience.com/wos/woscc/full-record/001270267500001 false true PublicationIdentifier 26860530 /api/publicationidentifier/26860530 Scopus: 85198447910 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85198447910 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85198447910 true true PublicationIdentifier 26873192 /api/publicationidentifier/26873192 PubMed: 39000143 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39000143 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39000143&dopt=Abstract false true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 55338551 /api/reference/55338551 1. 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(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 13<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10063746"><a href="/gui2/?type=authors&mode=browse&sel=10063746" target="_blank">Hajdú Gábor ✉ (<span class="authorship-author-name">Hajdú Gábor</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10098941"><a href="/gui2/?type=authors&mode=browse&sel=10098941" target="_blank">Szathmári Csenge (<span class="authorship-author-name">Szathmári Csenge</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012506"><a href="/gui2/?type=authors&mode=browse&sel=10012506" target="_blank">Sőti Csaba ✉ (<span class="authorship-author-name">Sőti Csaba</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35079836" target="_blank">Modeling Host–Pathogen Interactions in C. elegans: Lessons Learned from Pseudomonas aeruginosa Infection</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">13</span> <span class="page"> Paper 7034. 21 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms25137034" target="_blank" href="https://doi.org/10.3390/ijms25137034"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001270267500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001270267500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85198447910" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85198447910"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39000143" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39000143&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 14 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;14 | WoS/Scopus jelölt:&nbsp;14 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35079836&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35079836</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K147337) Támogató: OTKA, (STIA-KFI-2020/132257/AOMBT/2020), (Baron Munchausen Program 2023/1) </div> <div class="lastModified">Utolsó módosítás: 2026.04.21. 11:01 Sonnevend Kinga (SE_AOK_OrvVegytan_Admin5_SK, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian Science Foundation [OTKA K147337]; Semmelweis University [STIA-KFI-2020/132257/AOMBT/2020]; Department of Molecular Biology of the Semmelweis University [2023/1] Funding text: The research in the authors' laboratory was funded by grants from the Hungarian Science Foundation (OTKA K147337) to Csaba Soti, from the Semmelweis University (STIA-...</pre> </div></div>