https://m2.mtmt.hu/ hun 2026-09-20 16:05 JournalArticle 35077353 VALIDATED true Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 1, Rome, 00168, Italy Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Pharmahungary Group, Szeged, Hungary MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary HCEMM-SU Cardiometabolic Immunology Research Group, Budapest, Hungary MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Budapest, Hungary Center of Excellence of Cardiovascular Sciences, Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy University and Fondazione Campus Bio-Medico, Rome, Italy Export Date: 09 June 2026; Cited By: 15; Correspondence Address: M. Camilli; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; email: Massimiliano.camilli1@policlinicogemelli.it; CODEN: BRCAB 0 false 2026-08-10T20:25:26.133+0000 2026-06-09T17:46:02.915+0000 2024-06-29T17:56:17.071+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2026-07-07T09:51:06.817+0000 2025-02-07T10:18:58.075+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:51:49.136+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Camilli, Massimiliano Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond true true /api/journal/656 REVIEWED true false 656 false 656 true 0300-8428 1435-1803 Journal FOREIGN 120 241 262 241 22 2025 Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and approved for treatment of diabetes mellitus, have been shown to exert pleiotropic metabolic and direct cardioprotective and nephroprotective effects that extend beyond their glucose-lowering action. These properties prompted their use in two frequently intertwined conditions, heart failure and chronic kidney disease. Their unique mechanism of action makes SGLT2i an attractive option also to lower the rate of cardiac events and improve overall survival of oncological patients with preexisting cardiovascular risk and/or candidate to receive cardiotoxic therapies. This review will cover biological foundations and clinical evidence for SGLT2i modulating myocardial function and metabolism, with a focus on their possible use as cardioprotective agents in the cardio-oncology settings. Furthermore, we will explore recently emerged SGLT2i effects on hematopoiesis and immune system, carrying the potential of attenuating tumor growth and chemotherapy-induced cytopenias. true 2024 true true true false true false NONE 2026-08-10 false 19 0 19 13 1 19 19 18 15 19 19 13 13 13 6 0 19 13 19 13 0 14 14 Folyóiratcikk Journal Article 24 19 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 0 2 0 2025 0 10 8 10 8 2026 0 7 5 7 5 D1 false false false false 2024-09-27T17:57:02.158+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); HCEMM-SE Kardiometabolikus Immunológia Kutatócs... 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55283462 /api/reference/55283462 169 10.1016/J.BIOPHA.2020.110821 false true Reference 55283463 /api/reference/55283463 170 10.1056/NEJMoa1504720 false true Reference 55283464 /api/reference/55283464 171 10.1016/J.JACCAO.2022.03.005 false true /api/publication/35077353 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Camilli Massimiliano ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Viscovo Marcello<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maggio Luca<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bonanni Alice </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Torre Ilaria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pellegrino Claudio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lamendola Priscilla </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tinti Lorenzo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Teofili Luciana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hohaus Stefan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lanza Gaetano Antonio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Peter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Rendszerfarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltan (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Crea Filippo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lombardo Antonella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Minotti Giorgio </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35077353" target="_blank">Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond</a></div> <div> <span class="journal-title">BASIC RESEARCH IN CARDIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0300-8428">0300-8428</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1435-1803">1435-1803</a>)</span>: <span class="journal-volume">120</span> <span class="page"> pp 241-262 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00395-024-01059-9" target="_blank" href="https://doi.org/10.1007/s00395-024-01059-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001256980900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001256980900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85197457276" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85197457276"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38935171" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38935171&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s00395-024-01059-9" target="_blank" href="https://link.springer.com/10.1007/s00395-024-01059-9"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85197457276?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85197457276?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 19</span> | Független: 13 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 18 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;19 | DOI jelölt:&nbsp;19 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35077353&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35077353</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.09. 19:46 Molnár-Taga Márta (SE 4-es admin) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:51 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 1, Rome, 00168, Italy Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cu...</pre> </div></div>