https://m2.mtmt.hu/ hun 2026-09-22 21:31 JournalArticle 35070284 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office: NKFIH [K 120342, K 135712, K-142904]; Doctoral School of Biology, Eoetvoes Lorand University; European Union Funding text: This work was supported by grants from the National Research, Development and Innovation Office: NKFIH, K 120342 (PI:& Aacute;.A.), K 135712 (PI:I.B.), K-142904 (PI:S.E.B.). B.S. is grateful for the support of the Doctoral School of Biology, Eoetvoes Lorand University. This work was supported by an Erasmus+ grant to S.R. from the European Union. 0 false 2026-09-09T10:09:12.363+0000 2025-01-28T09:03:18.500+0000 2024-06-25T13:06:01.316+0000 true 10019782 Csámer Iván /api/admin/10019782 Admin true 10019782 2026-06-01T14:54:36.643+0000 2025-01-28T09:03:18.753+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-06-04T09:21:53.629+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Osztie, Rita Comprehensive Characterization of Phytochemical Composition, Membrane Permeability, and Antiproliferative Activity of Juglans nigra Polyphenols true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 13 6930 6930 28 2024 The aim of our study was the detailed polyphenol profiling of Juglans nigra and the characterization of the membrane permeability and antiproliferative properties of its main phenolics. A total of 161 compounds were tentatively identified in J. nigra bark, leaf, and pericarp extracts by ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HR-MS/MS). Eight compounds including myricetin-3-O-rhamnoside (86), quercetin-3-O-rhamnoside (106), quercetin-3-O-xyloside (74), juglone (141), 1,2,3,4-tetrahydro-7,8-dihydroxy-4-oxonaphthalen-1-yl-6-O-galloyl-glucoside (92), ellagic acid (143), gallic acid (14), and ethyl gallate (58) were isolated from J. nigra pericarp. The in vitro antiproliferative activity of the isolated compounds was investigated against three human cancer cell lines, confirming that juglone (141) inhibits cell proliferation in all of them, and has similar activity as the clinical standards. The permeability of the isolated compounds across biological membranes was evaluated by the parallel artificial membrane permeability assay (PAMPA). Both juglone (141) and ethyl-gallate (58) showed positive results in the blood–brain-barrier-specific PAMPA-BBB study. Juglone (141) also possesses logPe values which indicates that it may be able to cross both the GI and BBB membranes via passive diffusion. 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/api/sjrrating/11489344 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 true 1605 true D1 DIRECT true true /api/publication/35070284 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10090281"><a href="/gui2/?type=authors&mode=browse&sel=10090281" target="_blank">Osztie Rita (<span class="authorship-author-name">Osztie Rita</span> <span class="authorAux-mtmt"> farmakognózia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Czeglédi Tamás </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ross Sarah </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086277"><a href="/gui2/?type=authors&mode=browse&sel=10086277" target="_blank">Stipsicz Bence (<span class="authorship-author-name">Stipsicz Bence András</span> <span class="authorAux-mtmt"> immunológia, peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Biológia Doktori Iskola; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/HUN-REN-ELTE Peptidkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070197"><a href="/gui2/?type=authors&mode=browse&sel=10070197" target="_blank">Kalydi Eszter (<span class="authorship-author-name">Kalydi Eszter</span> <span class="authorAux-mtmt"> NMR spektroszkópia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Szerves Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001293"><a href="/gui2/?type=authors&mode=browse&sel=10001293" target="_blank">Béni Szabolcs (<span class="authorship-author-name">Béni Szabolcs</span> <span class="authorAux-mtmt"> NMR-spektroszkópia, analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020703"><a href="/gui2/?type=authors&mode=browse&sel=10020703" target="_blank">Boldizsár Imre (<span class="authorship-author-name">Boldizsár Imre</span> <span class="authorAux-mtmt"> Farmakobotanika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Növényszervezettani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053151"><a href="/gui2/?type=authors&mode=browse&sel=10053151" target="_blank">Riethmüller Eszter (<span class="authorship-author-name">Riethmüller Eszter</span> <span class="authorAux-mtmt"> Gyógyszerészeti tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002049"><a href="/gui2/?type=authors&mode=browse&sel=10002049" target="_blank">Bősze Szilvia E. (<span class="authorship-author-name">Bősze Szilvia</span> <span class="authorAux-mtmt"> Peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/HUN-REN-ELTE Peptidkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032430"><a href="/gui2/?type=authors&mode=browse&sel=10032430" target="_blank">Alberti Ágnes ✉ (<span class="authorship-author-name">Alberti Ágnes</span> <span class="authorAux-mtmt"> Farmakognózia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35070284" target="_blank">Comprehensive Characterization of Phytochemical Composition, Membrane Permeability, and Antiproliferative Activity of Juglans nigra Polyphenols</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">13</span> <span class="page"> Paper 6930. 28 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms25136930" target="_blank" href="https://doi.org/10.3390/ijms25136930"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001266751500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001266751500001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="120407" target="_blank" href="https://edit.elte.hu/handle/10831/120407"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85198429824" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85198429824"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39000038" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39000038&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span> | Független: 15 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35070284&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35070284</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (K 120342) Támogató: NKFIH, (OTKA NKFIH K-135712), (K142904) </div> <div class="lastModified">Utolsó módosítás: 2025.01.28. 10:03 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <div class="lockedBy">Központi kezelésű 2025.06.04. 11:21 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office: NKFIH [K 120342, K 135712, K-142904]; Doctoral School of Biology, Eoetvoes Lorand University; European Union Funding text: This work was supported by grants from the National Research, Development and Innovation Office: NKFIH, K 120342 (PI:& Aacute;.A.), K 135712 (PI:I.B.), K-142904 (PI:S.E.B.). B...</pre> </div></div>