https://m2.mtmt.hu/ hun 2026-05-25 09:54 JournalArticle 35062506 VALIDATED true 0 false 2026-05-23T23:08:05.495+0000 2024-07-09T09:06:24.724+0000 2024-06-21T10:21:56.095+0000 true 10000652 Lakatos Péter László /api/author/10000652 Author Lakatos Péter László (Belgyógyászat, gasztroenterológia, hepatológia) true 10000652 2024-07-03T09:46:31.792+0000 2024-07-03T09:46:31.792+0000 2024-07-03T09:46:36.464+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin Molnár-Taga Márta (SE_AOK_1Bel_Onkol_Admin5_MTM, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Pattarapuntakul, Tanawat true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 13 12 3606 3606 10 2024 Background: Proton pump inhibitor (PPI) therapy is well-established for its effectiveness in reducing re-bleeding in high-risk peptic ulcer patients following endoscopic hemostasis. Vonoprazan (VPZ) has demonstrated the capacity to achieve gastric pH levels exceeding 4, comparable to PPIs. This study aims to evaluate the comparative efficacy of intravenous PPI infusion versus VPZ in preventing re-bleeding after endoscopic hemostasis in patients with high-risk peptic ulcers. Methods: A randomized, double-blind, controlled, and double-dummy design was employed. Patients with peptic ulcer bleeding (Forrest class IA/IB or IIA/IIB) who underwent endoscopic hemostasis were randomly assigned to either the PPI group or the VPZ group. Re-bleeding rates at 3, 7, and 30 days, the number of blood transfusions required, length of hospitalization, and ulcer healing rate at 56 days were assessed. Results: A total of 44 eligible patients were enrolled, including 20 patients (PPI group, n = 11; VPZ group, n = 9) with high-risk peptic ulcers. The mean age was 66 years, with 70% being male. Re-bleeding within 72 h occurred in 9.1% of the PPI group versus 0% in the VPZ group (p = 1.000). There was no significant difference in re-bleeding rates within 7 days and 30 days (18.2% vs. 11.1%, p = 1.000). Additionally, the ulcer healing rate did not significantly differ between the groups (87.5% vs. 77.8%). Conclusions: This pilot study demonstrates comparable efficacy between oral vonoprazan and continuous PPI infusion in preventing recurrent bleeding events among high-risk peptic ulcer patients following successful endoscopic hemostasis. true 2024 true true true false true false GOLD 2026-05-24 true https://doi.org/10.3390/jcm13123606 2 2 2 2 0 2 2 1 1 2 2 2 2 2 0 0 2 2 2 2 0 0 0 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 1 1 1 1 Q1 false false false false 2024-07-02T09:46:36.302+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K) 1 5 1 10 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 117992962 /api/authorship/117992962 Pattarapuntakul, Tanawat 1 0.1 true false false Pattarapuntakul Tanawat true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992963 /api/authorship/117992963 Wong, Thanawin* 2 0.1 true false false Wong Thanawin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992964 /api/authorship/117992964 Wetwittayakhlang, Panu ✉ 3 0.1 false false true Wetwittayakhlang Panu true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992965 /api/authorship/117992965 Netinatsunton, Nisa 4 0.1 false false false Netinatsunton Nisa true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992966 /api/authorship/117992966 Keeratichananont, Suriya 5 0.1 false false false Keeratichananont Suriya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992967 /api/authorship/117992967 Kaewdech, Apichat 6 0.1 false false false Kaewdech Apichat true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992968 /api/authorship/117992968 Jandee, Sawangpong 7 0.1 false false false Jandee Sawangpong true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992969 /api/authorship/117992969 Chamroonkul, Naichaya 8 0.1 false false false Chamroonkul Naichaya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992970 /api/authorship/117992970 Sripongpun, Pimsiri 9 0.1 false false false Sripongpun Pimsiri true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 117992971 /api/authorship/117992971 Lakatos, Peter L. ✉ [Lakatos, Péter László (Belgyógyászat, ga...), szerző] Belgyógyászati és Onkológiai Klinika (SE / AOK / K) 10 0.1 false true true Author 10000652 /api/author/10000652 Lakatos Péter László (Belgyógyászat, gasztroenterológia, hepatológia) Lakatos Péter László true 10000652 true Lakatos Peter L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 26704519 /api/publicationidentifier/26704519 DOI: 10.3390/jcm13123606 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcm13123606 https://doi.org/10.3390/jcm13123606 false true PublicationIdentifier 26763425 /api/publicationidentifier/26763425 WoS: 001255994000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001255994000001 https://www.webofscience.com/wos/woscc/full-record/001255994000001 true true PublicationIdentifier 26774232 /api/publicationidentifier/26774232 Scopus: 85197200915 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85197200915 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85197200915 true true PublicationIdentifier 26704520 /api/publicationidentifier/26704520 PubMed: 38930134 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 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Andriulli 2008: High- versus Low-Dose Proton Pump Inhibitors after Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding: A Multicentre, Randomized Study., Am. J. Gastroenterol., 103, p. 3011, DOI: 10.1111/j.1572-0241.2008.02149.x 1 10.1111/j.1572-0241.2008.02149.x false true Reference 55058139 /api/reference/55058139 2. Barkun 2019: Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group., Ann. Intern. Med., 171, p. 805, DOI: 10.7326/M19-1795 2 10.7326/M19-1795 false true Reference 55058140 /api/reference/55058140 3. Chung 2014: Predictive Factors for Endoscopic Hemostasis in Patients with Upper Gastrointestinal Bleeding., Clin. Endosc., 47, p. 121, DOI: 10.5946/ce.2014.47.2.121 3 10.5946/ce.2014.47.2.121 false true Reference 55058141 /api/reference/55058141 4. Barkun 2004: The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE): Endoscopic Hemostasis and Proton Pump Inhibition Are Associated with Improved Outcomes in a Real-Life Setting., Am. J. Gastroenterol., 99, p. 1238, DOI: 10.1111/j.1572-0241.2004.30272.x 4 10.1111/j.1572-0241.2004.30272.x false true Reference 55058142 /api/reference/55058142 5. Sung 2009: Intravenous Esomeprazole for Prevention of Recurrent Peptic Ulcer Bleeding: A Randomized Trial., Ann. Intern. Med., 150, p. 455, DOI: 10.7326/0003-4819-150-7-200904070-00105 5 10.7326/0003-4819-150-7-200904070-00105 false true Reference 55058143 /api/reference/55058143 6. Lau 2000: Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers., N. Engl. J. Med., 343, p. 310, DOI: 10.1056/NEJM200008033430501 6 10.1056/NEJM200008033430501 false true Reference 55058144 /api/reference/55058144 7. Sung 2014: Effects of Intravenous and Oral Esomeprazole in the Prevention of Recurrent Bleeding from Peptic Ulcers after Endoscopic Therapy., Am. J. Gastroenterol., 109, p. 1005, DOI: 10.1038/ajg.2014.105 7 10.1038/ajg.2014.105 false true Reference 55058145 /api/reference/55058145 8. Yen, H.-H., Yang, C.-W., Su, W.-W., Soon, M.-S., Wu, S.-S., and Lin, H.-J. (2012). Oral versus Intravenous Proton Pump Inhibitors in Preventing Re-Bleeding for Patients with Peptic Ulcer Bleeding after Successful Endoscopic Therapy. BMC Gastroenterol., 12., DOI: 10.1186/1471-230X-12-66 8 10.1186/1471-230X-12-66 false true Reference 55058146 /api/reference/55058146 9. Gralnek 2021: Endoscopic Diagnosis and Management of Nonvariceal Upper Gastrointestinal Hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) Guideline—Update 2021., Endoscopy, 53, p. 300, DOI: 10.1055/a-1369-5274 9 10.1055/a-1369-5274 false true Reference 55058147 /api/reference/55058147 10. Udd 2005: The Effect of Regular and High Doses of Omeprazole on the Intragastric Acidity in Patients with Bleeding Peptic Ulcer Treated Endoscopically: A Clinical Trial with Continuous Intragastric pH Monitoring., Eur. J. Gastroenterol. Hepatol., 17, p. 1351, DOI: 10.1097/00042737-200512000-00014 10 10.1097/00042737-200512000-00014 false true Reference 55058148 /api/reference/55058148 11. Laine 2008: Intragastric pH with Oral vs Intravenous Bolus plus Infusion Proton-Pump Inhibitor Therapy in Patients with Bleeding Ulcers., Gastroenterology, 134, p. 1836, DOI: 10.1053/j.gastro.2008.03.006 11 10.1053/j.gastro.2008.03.006 false true Reference 55058149 /api/reference/55058149 12. Jenkins 2015: Randomised Clinical Trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Repeated Doses of TAK-438 (Vonoprazan), a Novel Potassium-Competitive Acid Blocker, in Healthy Male Subjects., Aliment. Pharmacol. Ther., 41, p. 636, DOI: 10.1111/apt.13121 12 10.1111/apt.13121 false true Reference 55058150 /api/reference/55058150 13. Oshima 2018: Potent Potassium-Competitive Acid Blockers: A New Era for the Treatment of Acid-Related Diseases., J. Neurogastroenterol. Motil., 24, p. 334, DOI: 10.5056/jnm18029 13 10.5056/jnm18029 false true Reference 55058151 /api/reference/55058151 14. Sakurai 2015: Acid-Inhibitory Effects of Vonoprazan 20 Mg Compared with Esomeprazole 20 Mg or Rabeprazole 10 Mg in Healthy Adult Male Subjects--a Randomised Open-Label Cross-over Study., Aliment. Pharmacol. Ther., 42, p. 719, DOI: 10.1111/apt.13325 14 10.1111/apt.13325 false true Reference 55058152 /api/reference/55058152 15. Kagawa 2016: Vonoprazan Prevents Bleeding from Endoscopic Submucosal Dissection-Induced Gastric Ulcers., Aliment. Pharmacol. Ther., 44, p. 583, DOI: 10.1111/apt.13747 15 10.1111/apt.13747 false true Reference 55058153 /api/reference/55058153 16. Kawai 2018: Vonoprazan Prevents Low-Dose Aspirin-Associated Ulcer Recurrence: Randomised Phase 3 Study., Gut, 67, p. 1033, DOI: 10.1136/gutjnl-2017-314852 16 10.1136/gutjnl-2017-314852 false true Reference 55058154 /api/reference/55058154 17. Chey 2022: Vonoprazan Triple and Dual Therapy for Helicobacter Pylori Infection in the United States and Europe: Randomized Clinical Trial., Gastroenterology, 163, p. 608, DOI: 10.1053/j.gastro.2022.05.055 17 10.1053/j.gastro.2022.05.055 false true Reference 55058155 /api/reference/55058155 18. Laine 2023: Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial., Gastroenterology, 164, p. 61, DOI: 10.1053/j.gastro.2022.09.041 18 10.1053/j.gastro.2022.09.041 false true Reference 55058156 /api/reference/55058156 19. Chiu 2009: Predicting Mortality in Patients with Bleeding Peptic Ulcers after Therapeutic Endoscopy., Clin. Gastroenterol. Hepatol., 7, p. 311, DOI: 10.1016/j.cgh.2008.08.044 19 10.1016/j.cgh.2008.08.044 false true Reference 55058157 /api/reference/55058157 20. Ramaekers 2016: The Predictive Value of Preendoscopic Risk Scores to Predict Adverse Outcomes in Emergency Department Patients With Upper Gastrointestinal Bleeding: A Systematic Review., Acad. Emerg. Med., 23, p. 1218, DOI: 10.1111/acem.13101 20 10.1111/acem.13101 false true Reference 55058158 /api/reference/55058158 21. Custovic 2020: Comparison of Glasgow-Blatchford Score and Rockall Score in Patients with Upper Gastrointestinal Bleeding., Med. Arch., 74, p. 270, DOI: 10.5455/medarh.2020.74.270-274 21 10.5455/medarh.2020.74.270-274 false true /api/publication/35062506 Pattarapuntakul Tanawat et al. Efficacy of Vonoprazan vs. Intravenous Proton Pump Inhibitor in Prevention of Re-Bleeding of High-Risk Peptic Ulcers: A Randomized Controlled Pilot Study. (2024) JOURNAL OF CLINICAL MEDICINE 2077-0383 13 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Pattarapuntakul Tanawat </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wong Thanawin^* </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wetwittayakhlang Panu ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Netinatsunton Nisa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Keeratichananont Suriya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kaewdech Apichat </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jandee Sawangpong </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chamroonkul Naichaya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sripongpun Pimsiri </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000652"><a href="/gui2/?type=authors&mode=browse&sel=10000652" target="_blank">Lakatos Peter L. ✉ (<span class="authorship-author-name">Lakatos Péter László</span> <span class="authorAux-mtmt"> Belgyógyászat, gasztroenterológia, hepatológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35062506" target="_blank">Efficacy of Vonoprazan vs. Intravenous Proton Pump Inhibitor in Prevention of Re-Bleeding of High-Risk Peptic Ulcers: A Randomized Controlled Pilot Study</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">12</span> <span class="page"> Paper 3606. 10 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm13123606" target="_blank" href="https://doi.org/10.3390/jcm13123606"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001255994000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001255994000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85197200915" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85197200915"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38930134" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38930134&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 (Nem nyilvános:&nbsp;2) </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35062506</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.07.09. 11:06 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>