https://m2.mtmt.hu/ eng 2026-05-30 16:04 JournalArticle 35059257 VALIDATED true Összes idézések száma a WoS-ban: 0 0 false 2026-05-23T23:03:35.596+0000 2026-03-06T09:48:52.817+0000 2024-06-20T08:24:48.952+0000 true 10054097 Nicsinger Anita /api/admin/10054097 Admin true 10054097 2026-04-23T13:25:47.045+0000 2026-04-23T13:25:47.045+0000 2026-03-06T09:48:53.089+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Nadasy, G.L. Vicious Circle With Venous Hypertension, Irregular Flow, Pathological Venous Wall Remodeling, and Valve Destruction in Chronic Venous Disease: A Review true true /api/journal/313 REVIEWED true false 313 false 313 true 0003-3197 1940-1574 Journal FOREIGN 77 3 271 295 271 25 2024 Substantial advances occurred in phlebological practice in the last two decades. With the use of modern diagnostic equipment, the patients’ venous hemodynamics can be examined in detail in everyday practice. Application of venous segments for arterial bypasses motivated studies on the effect of hemodynamic load on the venous wall. New animal models have been developed to study hemodynamic effects on the venous system. In vivo and in vitro studies revealed cellular phase transitions of venous endothelial, smooth muscle, and fibroblastic cells and changes in connective tissue composition, under hemodynamic load and at different locations of the chronically diseased venous system. This review is an attempt to integrate our knowledge from epidemiology, paleoanthropology and anthropology, clinical and experimental hemodynamic studies, histology, cell physiology, cell pathology, and molecular biology on the complex pathomechanism of this frequent disease. Our conclusion is that the disease is initiated by limited genetic adaptation of mankind not to bipedalism but to bipedalism in the unmoving standing or sitting position. In the course of the disease several pathologic vicious circles emerge, sustained venous hypertension inducing cellular phase transitions, chronic wall inflammation, apoptosis of cells, pathologic dilation, and valvular damage which, in turn, further aggravate the venous hypertension. © The Author(s) 2024. Funding 2041530 /api/funding/2041530 false true Funding 2041531 /api/funding/2041531 false true Funding 2041532 /api/funding/2041532 false true true 2024 true true true false true false NONE 2026-05-24 false 2 0 2 2 0 2 2 2 2 2 2 2 2 2 0 0 2 2 2 2 0 24 24 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 1 1 1 1 Q2 false false false false 2024-09-18T08:25:28.519+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Ortopédiai Klinika (SE / AOK / K); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Élettani Intézet (SE / AOK / I) 5 50 5 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 117980430 /api/authorship/117980430 1 0.14285715 true false true Author 10023262 /api/author/10023262 Nádasy György László true 10023262 true Nadasy G.L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117980431 /api/authorship/117980431 2 0.14285715 false false false Patai B.B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117980432 /api/authorship/117980432 3 0.143 false false false Author 10015399 /api/author/10015399 Molnár Andrea Ágnes true 10015399 true Molnar A.A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117980433 /api/authorship/117980433 4 0.143 false false false Author 10053136 /api/author/10053136 Hetthéssy Judit true 10053136 true Hetthessy J.R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117980434 /api/authorship/117980434 5 0.143 false false false Author 10000119 /api/author/10000119 Tőkés Anna-Mária true 10000119 true Tokes A.-M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117980435 /api/authorship/117980435 6 0.14285715 false false false Varady Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117980436 /api/authorship/117980436 7 0.143 false true false Author 10010428 /api/author/10010428 Bednárikné Dörnyei Gabriella true 10010428 true Dornyei G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26696012 /api/publicationidentifier/26696012 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1177/00033197241256680 https://doi.org/10.1177/00033197241256680 false true PublicationIdentifier 26696013 /api/publicationidentifier/26696013 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001242001100001 https://www.webofscience.com/wos/woscc/full-record/001242001100001 false true PublicationIdentifier 26696011 /api/publicationidentifier/26696011 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85195552992 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85195552992 false true PublicationIdentifier 26717665 /api/publicationidentifier/26717665 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38839285 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38839285&dopt=Abstract true true Classification 12124 /api/classification/12124 true true Keyword 9926 /api/keyword/9926 true 9926 true Keyword 1009614 /api/keyword/1009614 true 1009614 true Keyword 1333222 /api/keyword/1333222 true 1333222 true Keyword 1573376 /api/keyword/1573376 true true Keyword 3483653 /api/keyword/3483653 true true SjrRating 11446571 /api/sjrrating/11446571 153 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q2 DIRECT true true /api/publication/35059257 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023262"><a href="/gui2/?type=authors&mode=browse&sel=10023262" target="_blank">Nadasy G.L. ✉ (<span class="authorship-author-name">Nádasy György László</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Patai B.B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015399"><a href="/gui2/?type=authors&mode=browse&sel=10015399" target="_blank">Molnar A.A. (<span class="authorship-author-name">Molnár Andrea Ágnes</span> <span class="authorAux-mtmt"> kardiológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053136"><a href="/gui2/?type=authors&mode=browse&sel=10053136" target="_blank">Hetthessy J.R. (<span class="authorship-author-name">Hetthéssy Judit</span> <span class="authorAux-mtmt"> Ortopédia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Orthopedics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000119"><a href="/gui2/?type=authors&mode=browse&sel=10000119" target="_blank">Tokes A.-M. (<span class="authorship-author-name">Tőkés Anna-Mária</span> <span class="authorAux-mtmt"> Emlőpathológia és biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Varady Z. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010428"><a href="/gui2/?type=authors&mode=browse&sel=10010428" target="_blank">Dornyei G. (<span class="authorship-author-name">Bednárikné Dörnyei Gabriella</span> <span class="authorAux-mtmt"> Érfiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Health Sciences">FHS</span>/Department of Morphology and Physiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35059257" target="_blank">Vicious Circle With Venous Hypertension, Irregular Flow, Pathological Venous Wall Remodeling, and Valve Destruction in Chronic Venous Disease: A Review</a></div> <div> <span class="journal-title">ANGIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0003-3197">0003-3197</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1940-1574">1940-1574</a>)</span>: <span class="journal-volume">77</span> <span class="journal-issue">3</span> <span class="page"> pp 271-295 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1177/00033197241256680" target="_blank" href="https://doi.org/10.1177/00033197241256680"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001242001100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001242001100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85195552992" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85195552992"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38839285" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38839285&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 2 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35059257&sort=publishedYear,desc&sort=title"> Number of cited publications: 24 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35059257</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (TO 32019) Funder: HSRF, (TO 42670) Funder: HSRF, (NVKP_16-1-2016-0004) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2026.03.06. 10:48 Gizella Áncsán (SE admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Összes idézések száma a WoS-ban: 0</pre> </div></div>