https://m2.mtmt.hu/ hun 2026-05-02 13:53 JournalArticle 34971900 VALIDATED true Export Date: 14 January 2025 Correspondence Address: Sternberg, C.N.; Englander Institute for Precision Medicine, 413 East 69th Street, United States; email: cns9006@med.cornell.edu 0 false 2026-03-10T06:54:16.013+0000 2025-04-07T10:12:04.549+0000 2024-06-10T12:56:53.573+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2025-03-17T09:32:52.404+0000 2025-03-17T09:32:52.404+0000 2025-04-07T10:12:01.327+0000 true 10051300 Háromszéki-Virág Fruzsina /api/admin/10051300 Admin true 10051300 2025-04-07T10:12:04.766+0000 true 10051300 Háromszéki-Virág Fruzsina /api/admin/10051300 Admin true 10051300 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sternberg, Cora N Final Results from SAUL, a Single-arm International Study of Atezolizumab in Unselected Patients with Pretreated Locally Advanced/Metastatic Urinary Tract Carcinoma true true /api/journal/10050020 REVIEWED true false 10050020 false 10050020 true 2405-4569 Journal FOREIGN 10 6 938 946 938 9 2024 We assessed the safety of atezolizumab in unselected patients (including understudied populations typically excluded from clinical trials) with pretreated urinary tract carcinoma (UTC). The prespecified final analysis updates previously reported safety and efficacy data.The single-arm prospective SAUL study (NCT02928406) enrolled 1004 patients with locally advanced/metastatic urothelial/non-urothelial UTC that had progressed during/after one to three prior treatment lines for advanced UTC (or <12 mo after [neo]adjuvant therapy). Broad eligibility criteria allowed enrollment of patients with complex comorbidities approximating the real-world setting. Patients received atezolizumab 1200 mg every 3 wk until disease progression or unacceptable toxicity. The primary endpoint was safety. Secondary endpoints included duration of response and overall survival (OS).The treated cohort included 10% of patients with poor performance status, 5% with creatinine clearance <30 ml/min, and 4% with autoimmune disease. At median follow-up of 55 mo, median atezolizumab duration was 2.8 mo (range 0-62); 68 patients (7%) continued atezolizumab for >4 yr. Treatment-related grade ≥3 adverse events occurred in 16% of patients (death in 1%); 8% discontinued atezolizumab for adverse events. Median OS was 8.6 mo (95% confidence interval 7.8-9.7) and 136 patients (14%) had OS longer than 4 yr. Limitations include the small sample size for some subgroups of special interest.Long-term safety and efficacy data continue to show a benefit of atezolizumab in unselected patients with UTC. Remarkably, 14% of patients lived for >4 yr after starting atezolizumab. These results can inform multidisciplinary team discussions and treatment decision-making for patients with UTC with complex comorbidities.The SAUL study looked at how well tolerated a drug called atezolizumab was in patients with urinary tract cancer who had already received up to three previous treatments for their cancer, including people who are usually not included in clinical trials because of other medical conditions. The length of survival after starting treatment was also assessed. Overall, the results show that atezolizumab was well tolerated. 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class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Huddart Robert A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Calabrò Fabio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kandula Geetha </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Skamnioti Pari </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Merseburger Axel S </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34971900" target="_blank">Final Results from SAUL, a Single-arm International Study of Atezolizumab in Unselected Patients with Pretreated Locally Advanced/Metastatic Urinary Tract Carcinoma</a></div> <div> <span class="journal-title">EUROPEAN UROLOGY FOCUS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2405-4569">2405-4569</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">6</span> <span class="page"> pp 938-946 </span> 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PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Urology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34971900&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34971900</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.04.07. 12:12 Háromszéki-Virág Fruzsina (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 14 January 2025 Correspondence Address: Sternberg, C.N.; Englander Institute for Precision Medicine, 413 East 69th Street, United States; email: cns9006@med.cornell.edu</pre> </div></div>