The role of spirituality in health and disease is a complex and emerging area of research.
Incorporating spirituality into the bio-psycho-social model of health and disease
leading to the bio-psycho-social-spiritual model provides a more comprehensive framework.
In this context, chronic disorders like primary Sjögren’s syndrome (pSS) are of interest
due to their intricate interactions between biological, psychological, and spiritual
factors. This study explored the relationship between spirituality, immune parameters,
and disease activity in pSS patients. Data from 108 patients were analyzed, including
self-assessed spirituality (answering to direct questions and completing the Spiritual
Transcendence Scale), immunological parameters and disease activity scores. The findings
revealed several associations. Individuals with spiritual attitudes or engaged in
regular prayer/meditation showed lower serum levels of autoantibodies specific to
pSS and lower disease activity scores. Spiritual engagement was also linked to decreased
perceived skin and tracheal dryness, suggesting potential benefits for physical symptoms.
These findings suggest that spirituality may play a significant role in modulating
immune responses and disease activity in pSS patients. The study underscores the importance
of considering spirituality as an integral part of the holistic approach to health
and disease, further expanding the understanding of the interconnectedness of biological,
psychological, and spiritual dimensions.
