https://m2.mtmt.hu/ eng 2026-07-27 17:58 JournalArticle 34922169 VALIDATED true 0 false 2026-07-17T00:06:53.774+0000 2026-02-17T11:49:51.140+0000 2024-06-06T06:55:35.335+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-02-17T11:49:51.693+0000 2026-02-17T11:49:51.693+0000 2024-11-28T06:12:45.659+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-07T09:27:09.512+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Edtmayer, Sophie A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia true true /api/journal/10015558 REVIEWED true false 10015558 false 10015558 true 2041-4889 2041-4889 Journal FOREIGN 15 5 369 369 12 2024 Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in two distinct alternatively spliced isoforms, the full-length isoform STAT3α and the C-terminally truncated isoform STAT3β. While STAT3α is predominantly described as an oncogenic driver, STAT3β has been suggested to act as a tumor suppressor. To elucidate the role of STAT3β in AML, we established a mouse model of STAT3β-deficient, MLL-AF9-driven AML. STAT3β deficiency significantly shortened survival of leukemic mice confirming its role as a tumor suppressor. Furthermore, RNA sequencing revealed enhanced STAT1 expression and interferon (IFN) signaling upon loss of STAT3β. Accordingly, STAT3β-deficient leukemia cells displayed enhanced sensitivity to blockade of IFN signaling through both an IFNAR1 blocking antibody and the JAK1/2 inhibitor Ruxolitinib. Analysis of human AML patient samples confirmed that elevated expression of IFN-inducible genes correlated with poor overall survival and low STAT3β expression. Together, our data corroborate the tumor suppressive role of STAT3β in a mouse model in vivo. Moreover, they provide evidence that its tumor suppressive function is linked to repression of the STAT1-mediated IFN response. These findings suggest that the STAT3β/α mRNA ratio is a significant prognostic marker in AML and holds crucial information for targeted treatment approaches. Patients displaying a low STAT3β/α mRNA ratio and unfavorable prognosis could benefit from therapeutic interventions directed at STAT1/IFN signaling. Funding 2041175 /api/funding/2041175 false true true true 2024 true true true false true false GOLD 2026-07-17 true https://doi.org/10.1038/s41419-024-06749-9 8 0 8 6 0 8 8 7 5 8 8 6 6 6 2 0 8 6 8 6 0 4 4 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 5 3 5 3 2026 0 2 2 2 2 D1 false false false false 2024-06-05T07:28:13.237+0000 Biofizikai Intézet (PTE / ÁOK); Bioinformatika Tanszék (SE / AOK / I); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 1 26 3 17 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 117054336 /api/authorship/117054336 1 0.05882353 true false false Edtmayer Sophie true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054337 /api/authorship/117054337 2 0.05882353 false false false Witalisz-Siepracka Agnieszka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054338 /api/authorship/117054338 3 0.05882353 false false false Zdársky Bernhard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054339 /api/authorship/117054339 4 0.05882353 false false false Heindl Kerstin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054340 /api/authorship/117054340 5 0.05882353 false false false Weiss Stefanie true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054341 /api/authorship/117054341 6 0.05882353 false false false Eder Thomas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054342 /api/authorship/117054342 7 0.05882353 false false false Dutta Sayantanee true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054343 /api/authorship/117054343 8 0.05882353 false false false Graichen Uwe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054344 /api/authorship/117054344 9 0.05882353 false false false Klee Sascha true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054345 /api/authorship/117054345 10 0.05882353 false false false Sharif Omar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054346 /api/authorship/117054346 11 0.05882353 false false false Wieser Rotraud true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054347 /api/authorship/117054347 12 0.059 false false false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054348 /api/authorship/117054348 13 0.05882353 false false false Poli Valeria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054349 /api/authorship/117054349 14 0.05882353 false false false Casanova Emilio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054350 /api/authorship/117054350 15 0.05882353 false false false Sill Heinz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054351 /api/authorship/117054351 16 0.05882353 false false false Grebien Florian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117054352 /api/authorship/117054352 17 0.059 false true true Stoiber Dagmar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26372255 /api/publicationidentifier/26372255 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41419-024-06749-9 https://doi.org/10.1038/s41419-024-06749-9 false true PublicationIdentifier 26478345 /api/publicationidentifier/26478345 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001233904000004 https://www.webofscience.com/wos/woscc/full-record/001233904000004 false true PublicationIdentifier 26496210 /api/publicationidentifier/26496210 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85194827500 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85194827500 false true PublicationIdentifier 26372254 /api/publicationidentifier/26372254 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38806478 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38806478&dopt=Abstract false true SjrRating 11447136 /api/sjrrating/11447136 9 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 true 2804 true D1 DIRECT true true /api/publication/34922169 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Edtmayer Sophie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Witalisz-Siepracka Agnieszka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zdársky Bernhard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heindl Kerstin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weiss Stefanie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eder Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dutta Sayantanee </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Graichen Uwe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Klee Sascha </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sharif Omar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wieser Rotraud </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Biophysics; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Poli Valeria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Casanova Emilio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sill Heinz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grebien Florian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stoiber Dagmar ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34922169" target="_blank">A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia</a></div> <div> <span class="journal-title">CELL DEATH AND DISEASE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-4889">2041-4889</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-4889">2041-4889</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">5</span> <span class="page"> Paper 369. 12 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41419-024-06749-9" target="_blank" href="https://doi.org/10.1038/s41419-024-06749-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001233904000004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001233904000004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85194827500" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85194827500"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38806478" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38806478&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Immunology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 6 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;8 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34922169&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34922169</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2026.02.17. 12:49 Éva Pécsi (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Centrally managed 2025.05.07. 11:27 Andrea Vándor (VA, admin) </div> </div></div>