Cost-effectiveness analyses rarely offer useful insights to policy decisions unless
their results are compared against a benchmark threshold. The cost-effectiveness threshold
(CET) represents the maximum acceptable monetary value for achieving a unit of health
gain. This study aimed to identify CET values on a global scale, provide an overview
of using multiple CETs, and propose a country-specific CET framework specifically
tailored for Egypt. The proposed framework aims to consider the globally identified
CETs, analyze global trends, and consider the local structure of Egypt’s healthcare
system.